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Phosphotyrosine signaling: evolving a new cellular communication system.

Abstract：

:Tyrosine phosphorylation controls many cellular functions. Yet the three-part toolkit that regulates phosphotyrosine signaling-tyrosine kinases, phosphotyrosine phosphatases, and Src Homology 2 (SH2) domains-is a relatively new innovation. Genomic analyses reveal how this revolutionary signaling system may have originated and why it rapidly became critical to metazoans.

journal_name

Cell

journal_title

Cell

authors

Lim WA,Pawson T

doi

10.1016/j.cell.2010.08.023

subject

Has Abstract

pub_date

2010-09-03 00:00:00

pages

661-7

issue

5

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(10)00954-2

journal_volume

142

pub_type

杂志文章

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