当前位置： SCI文献检索 > CELL期刊下所有文献 > p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

Abstract：

:gamma-Irradiation of human diploid fibroblasts in the G1 interval caused arrest of the cell cycle prior to S phase. This cell cycle block was correlated with a lack of activation of both cyclin E-Cyclin-dependent kinase 2 (Cdk2) and cyclin A-Cdk2 kinases and depended on wild-type p53. Although the accumulation of cyclin A was strongly inhibited in gamma-irradiated cells, cyclin E accumulated and bound Cdk2 at normal levels but remained in an inactive state. We found that both whole-cell lysates and inactive cyclin E-Cdk2 complexes prepared from irradiated cells contained an activity capable of inactivating cyclin E-Cdk2 complexes. The protein responsible for this activity was shown to be p21CIP1/WAF1, recently described as a p53-inducible Cdk inhibitor. Our data suggest a model in which ionizing radiation confers G1 arrest via the p53-mediated induction of a Cdk inhibitor protein.

journal_name

Cell

journal_title

Cell

authors

Dulić V,Kaufmann WK,Wilson SJ,Tlsty TD,Lees E,Harper JW,Elledge SJ,Reed SI

doi

10.1016/0092-8674(94)90379-4

subject

Has Abstract

pub_date

1994-03-25 00:00:00

pages

1013-23

issue

6

eissn

0092-8674

issn

1097-4172

pii

0092-8674(94)90379-4

journal_volume

76

pub_type

杂志文章

相关文献

CELL文献大全
  • The immortal strand hypothesis: segregation and reconstruction.

    abstract：:The immortal strand hypothesis posits that the propensity of stem cell compartments to give rise to cancer in later life can be minimized if stem cells, during the process of self-renewal, retain those DNA strands with the fewest mutations acquired during DNA replication. In this Essay, I explore evidence in support o...

    journal_title：Cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.cell.2007.06.019

    authors： Rando TA

    更新日期：2007-06-29 00:00:00

  • Both layers of the COPII coat come into view.

    abstract：:Anterograde transport in the early secretory pathway is mediated by COPII-coated vesicles. Stagg et al. (2008) have now visualized the double-layered COPII coat using electron cryomicroscopy, providing insight into how coats are assembled to accommodate cargo of different sizes. ...

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.cell.2008.07.027

    authors： Hughson FM

    更新日期：2008-08-08 00:00:00

  • Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow.

    abstract：:Cell-cell junctions respond to mechanical forces by changing their organization and function. To gain insight into the mechanochemical basis underlying junction mechanosensitivity, we analyzed tight junction (TJ) formation between the enveloping cell layer (EVL) and the yolk syncytial layer (YSL) in the gastrulating z...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2019.10.006

    authors： Schwayer C,Shamipour S,Pranjic-Ferscha K,Schauer A,Balda M,Tada M,Matter K,Heisenberg CP

    更新日期：2019-10-31 00:00:00

  • Follicular dendritic cells emerge from ubiquitous perivascular precursors.

    abstract：:The differentiation of follicular dendritic cells (FDC) is essential to the remarkable microanatomic plasticity of lymphoid follicles. Here we show that FDC arise from ubiquitous perivascular precursors (preFDC) expressing platelet-derived growth factor receptor β (PDGFRβ). PDGFRβ-Cre-driven reporter gene recombinatio...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2012.05.032

    authors： Krautler NJ,Kana V,Kranich J,Tian Y,Perera D,Lemm D,Schwarz P,Armulik A,Browning JL,Tallquist M,Buch T,Oliveira-Martins JB,Zhu C,Hermann M,Wagner U,Brink R,Heikenwalder M,Aguzzi A

    更新日期：2012-07-06 00:00:00

  • A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis.

    abstract：:New neurons arise from quiescent adult neural progenitors throughout life in specific regions of the mammalian brain. Little is known about the embryonic origin and establishment of adult neural progenitors. Here, we show that Hopx+ precursors in the mouse dentate neuroepithelium at embryonic day 11.5 give rise to pro...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2019.02.010

    authors： Berg DA,Su Y,Jimenez-Cyrus D,Patel A,Huang N,Morizet D,Lee S,Shah R,Ringeling FR,Jain R,Epstein JA,Wu QF,Canzar S,Ming GL,Song H,Bond AM

    更新日期：2019-04-18 00:00:00

  • Decoding neural circuits that control compulsive sucrose seeking.

    abstract：:The lateral hypothalamic (LH) projection to the ventral tegmental area (VTA) has been linked to reward processing, but the computations within the LH-VTA loop that give rise to specific aspects of behavior have been difficult to isolate. We show that LH-VTA neurons encode the learned action of seeking a reward, indepe...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2015.01.003

    authors： Nieh EH,Matthews GA,Allsop SA,Presbrey KN,Leppla CA,Wichmann R,Neve R,Wildes CP,Tye KM

    更新日期：2015-01-29 00:00:00

  • Activation of STAT6 by STING is critical for antiviral innate immunity.

    abstract：:STAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular cytokines. We now show that STAT6 is required for innate immune signaling in response to virus infection. Viruses or cytoplasmic nucleic acids trigger STING (also named MITA/ERIS) to recruit STAT6 to the endoplasmic reticulum, ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2011.09.022

    authors： Chen H,Sun H,You F,Sun W,Zhou X,Chen L,Yang J,Wang Y,Tang H,Guan Y,Xia W,Gu J,Ishikawa H,Gutman D,Barber G,Qin Z,Jiang Z

    更新日期：2011-10-14 00:00:00

  • Identification of the gene and mRNA for the adenovirus terminal protein precursor.

    abstract：:The precursor of the 55K adenovirus terminal protein is an 87K protein that is covalently linked to viral DNA. This protein is likely to be identical to the 80,000 dalton protein described by Challberg et al. (1980). The mRNA for the 87K terminal protein precursor, like that for the E2-72K DNA binding protein, is dete...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(81)90145-8

    authors： Stillman BW,Lewis JB,Chow LT,Mathews MB,Smart JE

    更新日期：1981-02-01 00:00:00

  • Going Public in Support of Science.

    abstract：:Scientists are stepping up like never before to support science in the public arena. In big and small ways, scientists are adopting creative ideas to promote science. ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2017.03.029

    authors： Matheson S

    更新日期：2017-04-06 00:00:00

  • Organ-level quorum sensing directs regeneration in hair stem cell populations.

    abstract：:Coordinated organ behavior is crucial for an effective response to environmental stimuli. By studying regeneration of hair follicles in response to patterned hair plucking, we demonstrate that organ-level quorum sensing allows coordinated responses to skin injury. Plucking hair at different densities leads to a regene...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2015.02.016

    authors： Chen CC,Wang L,Plikus MV,Jiang TX,Murray PJ,Ramos R,Guerrero-Juarez CF,Hughes MW,Lee OK,Shi S,Widelitz RB,Lander AD,Chuong CM

    更新日期：2015-04-09 00:00:00

  • A MicroRNA targeting dicer for metastasis control.

    abstract：:Although specific microRNAs (miRNAs) can be upregulated in cancer, global miRNA downregulation is a common trait of human malignancies. The mechanisms of this phenomenon and the advantages it affords remain poorly understood. Here we identify a microRNA family, miR-103/107, that attenuates miRNA biosynthesis by target...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2010.05.017

    authors： Martello G,Rosato A,Ferrari F,Manfrin A,Cordenonsi M,Dupont S,Enzo E,Guzzardo V,Rondina M,Spruce T,Parenti AR,Daidone MG,Bicciato S,Piccolo S

    更新日期：2010-06-25 00:00:00

  • Structural characterization of the TAP molecule: a phosphatidylinositol-linked glycoprotein distinct from the T cell receptor/T3 complex and Thy-1.

    abstract：:Here we characterize the T-cell-activating protein (TAP), an Ly-6 gene product involved in T cell activation, as a glycoprotein with a molecular weight of 10-12 kd under nonreducing conditions and 15-18 kd under reducing ones. Two of the three bands that are precipitated from metabolically labeled cells are expressed ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(86)90593-3

    authors： Reiser H,Oettgen H,Yeh ET,Terhorst C,Low MG,Benacerraf B,Rock KL

    更新日期：1986-11-07 00:00:00

  • Identification and purification of a protein that binds the yeast ARS consensus sequence.

    abstract：:We have identified a yeast protein that binds specifically to the ARS consensus sequence. By two-step chromatography we have purified the factor to apparent homogeneity as a single polypeptide of 67 kd. The purified ARS consensus-binding protein (ACBP) recognizes the ARS consensus of the four genomic ARS elements test...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(91)90319-t

    authors： Hofmann JF,Gasser SM

    更新日期：1991-03-08 00:00:00

  • Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay.

    abstract：:Cellular mRNAs exist in messenger ribonucleoprotein (mRNP) complexes, which undergo transitions during the lifetime of the mRNAs and direct posttranscriptional gene regulation. A final posttranscriptional step in gene expression is the turnover of the mRNP, which involves degradation of the mRNA and recycling of assoc...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2010.11.043

    authors： Franks TM,Singh G,Lykke-Andersen J

    更新日期：2010-12-10 00:00:00

  • Acetylation-dependent signal transduction for type I interferon receptor.

    abstract：:Cytokine-activated receptors initiate intracellular signaling by recruiting protein kinases that phosphorylate the receptors on tyrosine residues, thus enabling docking of SH2 domain-bearing activating factors. Here we report that in response to type 1 interferon (IFNalpha), IFNalpha receptors recruit cytoplasmic CREB...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2007.07.034

    authors： Tang X,Gao JS,Guan YJ,McLane KE,Yuan ZL,Ramratnam B,Chin YE

    更新日期：2007-10-05 00:00:00

  • A Species-Wide Inventory of NLR Genes and Alleles in Arabidopsis thaliana.

    abstract：:Infectious disease is both a major force of selection in nature and a prime cause of yield loss in agriculture. In plants, disease resistance is often conferred by nucleotide-binding leucine-rich repeat (NLR) proteins, intracellular immune receptors that recognize pathogen proteins and their effects on the host. Consi...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2019.07.038

    authors： Van de Weyer AL,Monteiro F,Furzer OJ,Nishimura MT,Cevik V,Witek K,Jones JDG,Dangl JL,Weigel D,Bemm F

    更新日期：2019-08-22 00:00:00

  • The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme.

    abstract：:We have cloned the C. elegans cell death gene ced-3. A ced-3 transcript is most abundant during embryogenesis, the stage during which most programmed cell deaths occur. The predicted CED-3 protein shows similarity to human and murine interleukin-1 beta-converting enzyme and to the product of the mouse nedd-2 gene, whi...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(93)90485-9

    authors： Yuan J,Shaham S,Ledoux S,Ellis HM,Horvitz HR

    更新日期：1993-11-19 00:00:00

  • Isolation, sequence analysis, and intron-exon arrangement of the gene encoding bovine rhodopsin.

    abstract：:We have isolated cDNA clones generated from the mRNA encoding the opsin apoprotein of bovine rhodopsin and used these cDNAs to isolate genomic DNA clones containing the complete opsin gene. Nucleotide sequence analysis of the cloned DNAs has yielded a complete amino acid sequence for bovine rhodopsin and provided an i...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(83)90537-8

    authors： Nathans J,Hogness DS

    更新日期：1983-10-01 00:00:00

  • Lessons from a failed γ-secretase Alzheimer trial.

    abstract：:γ-Secretase proteases have been associated with pathology in Alzheimer disease (AD), but we are just beginning to understand their basic mechanisms and physiological roles. A negative drug trial with a broad spectrum γ-secretase inhibitor in AD patients has severely dampened enthusiasm for the potential of pursuing γ-...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2014.10.016

    authors： De Strooper B

    更新日期：2014-11-06 00:00:00

  • p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches.

    abstract：:Insertion/deletion (IDL) mismatches in DNA are lesions consisting of extra bases on one strand. Here, the binding of p53 and its 14 kDa C-terminal domain to DNAs containing one or three 3-cytosine IDL mismatches was examined. Electron microscopy showed that both p53 forms bound predominantly as tetramers at the lesion...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(05)80006-6

    authors： Lee S,Elenbaas B,Levine A,Griffith J

    更新日期：1995-06-30 00:00:00

  • Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.

    abstract：:Autosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telomerase. To examine the dosage effect of telomerase, we generated a line of mTR+/- mice on the CAST/EiJ background, which has short telomeres. Interbreeding of heterozygotes resulted in progressive telomere shortening, indicating...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2005.11.020

    authors： Hao LY,Armanios M,Strong MA,Karim B,Feldser DM,Huso D,Greider CW

    更新日期：2005-12-16 00:00:00

  • Ferroptosis: an iron-dependent form of nonapoptotic cell death.

    abstract：:Nonapoptotic forms of cell death may facilitate the selective elimination of some tumor cells or be activated in specific pathological states. The oncogenic RAS-selective lethal small molecule erastin triggers a unique iron-dependent form of nonapoptotic cell death that we term ferroptosis. Ferroptosis is dependent up...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2012.03.042

    authors： Dixon SJ,Lemberg KM,Lamprecht MR,Skouta R,Zaitsev EM,Gleason CE,Patel DN,Bauer AJ,Cantley AM,Yang WS,Morrison B 3rd,Stockwell BR

    更新日期：2012-05-25 00:00:00

  • Three-dimensional visualization of the rotavirus hemagglutinin structure.

    abstract：:Three-dimensional structures of a native simian and reassortant rotavirus have been determined by electron cryomicroscopy and computer image processing. The structural features of the native virus confirm that the hemagglutinin spike is a dimer of VP4, substantiated by in vivo radiolabeling studies. Exchange of native...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(93)90516-s

    authors： Shaw AL,Rothnagel R,Chen D,Ramig RF,Chiu W,Prasad BV

    更新日期：1993-08-27 00:00:00

  • Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop.

    abstract：:Synaptic plasticity in response to changes in physiologic state is coordinated by hormonal signals across multiple neuronal cell types. Here, we combine cell-type-specific electrophysiological, pharmacological, and optogenetic techniques to dissect neural circuits and molecular pathways controlling synaptic plasticity...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2011.07.039

    authors： Yang Y,Atasoy D,Su HH,Sternson SM

    更新日期：2011-09-16 00:00:00

  • Interspecies Competition Impacts Targeted Manipulation of Human Gut Bacteria by Fiber-Derived Glycans.

    abstract：:Development of microbiota-directed foods (MDFs) that selectively increase the abundance of beneficial human gut microbes, and their expressed functions, requires knowledge of both the bioactive components of MDFs and the mechanisms underlying microbe-microbe interactions. Here, gnotobiotic mice were colonized with a d...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2019.08.011

    authors： Patnode ML,Beller ZW,Han ND,Cheng J,Peters SL,Terrapon N,Henrissat B,Le Gall S,Saulnier L,Hayashi DK,Meynier A,Vinoy S,Giannone RJ,Hettich RL,Gordon JI

    更新日期：2019-09-19 00:00:00

  • Trans-activation by HIV-1 Tat via a heterologous RNA binding protein.

    abstract：:The HIV-1 trans-activator Tat increases levels of viral gene expression and replication. The target for Tat is an RNA stem-loop called TAR, located at the 5' end of all viral transcripts. To study the mechanism of action and map functional domains of Tat, we fused Tat to the coat protein of bacteriophage MS2, an RNA b...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(90)90121-t

    authors： Selby MJ,Peterlin BM

    更新日期：1990-08-24 00:00:00

  • Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.

    abstract：:Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a growing public health concern. Systems-level analysis of how flaviviruses hijack cellular processes through virus-host protein-protein interactions (PPIs) provides information about their replication and pathogenic mechanisms. We u...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2018.11.028

    authors： Shah PS,Link N,Jang GM,Sharp PP,Zhu T,Swaney DL,Johnson JR,Von Dollen J,Ramage HR,Satkamp L,Newton B,Hüttenhain R,Petit MJ,Baum T,Everitt A,Laufman O,Tassetto M,Shales M,Stevenson E,Iglesias GN,Shokat L,Tripathi

    更新日期：2018-12-13 00:00:00

  • Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs.

    abstract：:The endoplasmic reticulum (ER) often forms stacked membrane sheets, an arrangement that is likely required to accommodate a maximum of membrane-bound polysomes for secretory protein synthesis. How sheets are stacked is unknown. Here, we used improved staining and automated ultrathin sectioning electron microscopy meth...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2013.06.031

    authors： Terasaki M,Shemesh T,Kasthuri N,Klemm RW,Schalek R,Hayworth KJ,Hand AR,Yankova M,Huber G,Lichtman JW,Rapoport TA,Kozlov MM

    更新日期：2013-07-18 00:00:00

  • Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma.

    abstract：:From a transplantable mouse teratoma it has been possible to derive an established keratinizing cell line (XB) which grows well in cultures containing lethally irradiated 3T3 fibroblasts at the correct density. Single cells of the keratinizing line grow into colonies each consisting of a stratified squamous epithelium...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(75)90183-x

    authors： Rheinwald JG,Green H

    更新日期：1975-11-01 00:00:00

  • Isolation of a circular derivative of yeast chromosome III: implications for the mechanism of mating type interconversion.

    abstract：:We describe genetic and physical characterization of rearrangements of chromosome III which result in changes of cell type in S. cerevisiae. Two types of rearrangements were obtained as rare events which caused a change at the locus controlling cell type, MAT, associated with a recessive lethal mutation, in one case f...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(79)90050-3

    authors： Strathern JN,Newlon CS,Herskowitz I,Hicks JB

    更新日期：1979-10-01 00:00:00