Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.

abstract：:Expression of pipe in the somatic tissue of the Drosophila ovary is required for the formation of embryonic dorsal-ventral polarity. pipe, which encodes an enzyme similar to the glycosaminoglycan-modifying enzyme heparan sulfate 2-O-sulfotransferase, is expressed in a spatially restricted domain of follicle cells on t...

journal_title：Cell

authors： Sen J,Goltz JS,Stevens L,Stein D

更新日期：1998-11-13 00:00:00

abstract：:Nuclear hormone receptors comprise a superfamily of ligand-modulated transcription factors that mediate the transcriptional activities of steroids, retinoids, and thyroid hormones. A growing number of related proteins have been identified that possess the structural features of hormone receptors, but that lack known l...

journal_title：Cell

authors： Forman BM,Goode E,Chen J,Oro AE,Bradley DJ,Perlmann T,Noonan DJ,Burka LT,McMorris T,Lamph WW,Evans RM,Weinberger C

更新日期：1995-06-02 00:00:00

abstract：:Histone DNA of Psammechinus miliaris was obtained in an enriched form by buoyant density gradient centrifugation and was cleaved into 6 kb repeat units (Birnstiel et al., 1975a) by the action of the specific endonucleases EcoRI and HindIII. Since it was suspected that the 6 kb unit harbored all five histone-coding seq...

journal_title：Cell

authors： Schaffner W,Gross K,Telford J,Birnstiel M

更新日期：1976-08-01 00:00:00

abstract：:Physiological concentrations of dihydrotestosterone (DHT) can specifically induce the release of fibrinolysin from androgen-dependent mammary carcinoma (Shionogi SC-115) cells in vitro. No fibrinolytic activity was observed in cells cultured either in the absence of DHT or presence of pharmacological concentrations of...

journal_title：Cell

authors： Mak TW,Rutledge G,Sutherland DJ

更新日期：1976-02-01 00:00:00

abstract：:Micronuclei of Tetrahymena thermophila contain two electrophoretically distinct forms of histone H3. The slower migrating micronuclear species, H3S, is indistinguishable from the macronuclear H3 by electrophoretic analyses in three gel systems and by partial proteolytic peptide mapping. The faster species, H3F, is uni...

journal_title：Cell

authors： Allis CD,Bowen JK,Abraham GN,Glover CV,Gorovsky MA

更新日期：1980-05-01 00:00:00

abstract：:The larval salivary glands of Drosophila melanogaster, which are widely used for cytogenic studies, are also useful for studying the regulation of specific protein synthesis during differentiation. These glands synthesize and secrete massive amounts of a glue which attaches the pupae to the substrate during metamorpho...

journal_title：Cell

authors： Beckendorf SK,Kafatos FC

更新日期：1976-11-01 00:00:00

abstract：:The recognition of specific DNA-binding sites by transcription factors is a critical yet poorly understood step in the control of gene expression. Members of the Hox family of transcription factors bind DNA by making nearly identical major groove contacts via the recognition helices of their homeodomains. In vivo spec...

journal_title：Cell

authors： Joshi R,Passner JM,Rohs R,Jain R,Sosinsky A,Crickmore MA,Jacob V,Aggarwal AK,Honig B,Mann RS

更新日期：2007-11-02 00:00:00

abstract：:In the developing nervous system, neural progenitors exit the cell cycle and differentiate on a precise schedule, yet the mechanisms driving this process remain poorly defined. Yan et al. (2009) now identify a thiol-redox reaction mediated by the membrane protein GDE2 and the peroxiredoxin protein Prdx1 that promotes ...

journal_title：Cell

authors： Novitch BG,Butler SJ

更新日期：2009-09-18 00:00:00

abstract：:The inhibitor of apoptosis (IAP) proteins suppress cell death by inhibiting the catalytic activity of caspases. Here we present the crystal structure of caspase-7 in complex with a potent inhibitory fragment from XIAP at 2.45 A resolution. An 18-residue XIAP peptide binds the catalytic groove of caspase-7, making exte...

journal_title：Cell

authors： Chai J,Shiozaki E,Srinivasula SM,Wu Q,Datta P,Alnemri ES,Shi Y

更新日期：2001-03-09 00:00:00

abstract：:The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cells and their microenvironment. Luo et al. (2007) recently demonstrated that tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization of IKKalpha in prostatic epithelial tumor cells. Th...

journal_title：Cell

authors： Affara NI,Coussens LM

更新日期：2007-04-06 00:00:00

abstract：:Throughout a 24-h period, the small intestine (SI) is exposed to diurnally varying food- and microbiome-derived antigenic burdens but maintains a strict immune homeostasis, which when perturbed in genetically susceptible individuals, may lead to Crohn disease. Herein, we demonstrate that dietary content and rhythmicit...

journal_title：Cell

authors： Tuganbaev T,Mor U,Bashiardes S,Liwinski T,Nobs SP,Leshem A,Dori-Bachash M,Thaiss CA,Pinker EY,Ratiner K,Adlung L,Federici S,Kleimeyer C,Moresi C,Yamada T,Cohen Y,Zhang X,Massalha H,Massasa E,Kuperman Y,Koni PA,H

更新日期：2020-09-17 00:00:00

abstract：:Cellular mRNAs exist in messenger ribonucleoprotein (mRNP) complexes, which undergo transitions during the lifetime of the mRNAs and direct posttranscriptional gene regulation. A final posttranscriptional step in gene expression is the turnover of the mRNP, which involves degradation of the mRNA and recycling of assoc...

journal_title：Cell

authors： Franks TM,Singh G,Lykke-Andersen J

更新日期：2010-12-10 00:00:00

abstract：:The transition from the juvenile to the adult phase of shoot development in plants is accompanied by changes in vegetative morphology and an increase in reproductive potential. Here, we describe the regulatory mechanism of this transition. We show that miR156 is necessary and sufficient for the expression of the juven...

journal_title：Cell

authors： Wu G,Park MY,Conway SR,Wang JW,Weigel D,Poethig RS

更新日期：2009-08-21 00:00:00

abstract：:Retrotransposons have shaped eukaryotic genomes for millions of years. To analyze the consequences of human L1 retrotransposition, we developed a genetic system to recover many new L1 insertions in somatic cells. Forty-two de novo integrants were recovered that faithfully mimic many aspects of L1s that accumulated sin...

journal_title：Cell

authors： Symer DE,Connelly C,Szak ST,Caputo EM,Cost GJ,Parmigiani G,Boeke JD

更新日期：2002-08-09 00:00:00

abstract：:As the pipeline of new antibiotics slows to a trickle, scientists are developing innovative strategies to unearth antibacterial compounds in unexpected places. ...

journal_title：Cell

authors： von Bubnoff A

更新日期：2006-12-01 00:00:00

abstract：:Even a simple sensory stimulus can elicit distinct innate behaviors and sequences. During sensorimotor decisions, competitive interactions among neurons that promote distinct behaviors must ensure the selection and maintenance of one behavior, while suppressing others. The circuit implementation of these competitive i...

journal_title：Cell

authors： Jovanic T,Schneider-Mizell CM,Shao M,Masson JB,Denisov G,Fetter RD,Mensh BD,Truman JW,Cardona A,Zlatic M

更新日期：2016-10-20 00:00:00

abstract：:The major site of in vivo transcriptional initiation for both heavy and light strands of human mitochondrial DNA is the displacement-loop region. Transcripts synthesized in vitro by human mitochondrial RNA polymerase were mapped to the nucleotide level and have identical 5' end map positions to those reported for in v...

journal_title：Cell

authors： Chang DD,Clayton DA

更新日期：1984-03-01 00:00:00

abstract：:Mitochondrial Ca(2+) (Ca(2+)(m)) uptake is mediated by an inner membrane Ca(2+) channel called the uniporter. Ca(2+) uptake is driven by the considerable voltage present across the inner membrane (ΔΨ(m)) generated by proton pumping by the respiratory chain. Mitochondrial matrix Ca(2+) concentration is maintained five ...

journal_title：Cell

authors： Mallilankaraman K,Doonan P,Cárdenas C,Chandramoorthy HC,Müller M,Miller R,Hoffman NE,Gandhirajan RK,Molgó J,Birnbaum MJ,Rothberg BS,Mak DO,Foskett JK,Madesh M

更新日期：2012-10-26 00:00:00

abstract：:Tyrosyl phosphorylation is implicated in the mechanism of insulin action. Mutation of the beta-subunit of the insulin receptor by substitution of tyrosyl residue 960 with phenylalanine had no effect on insulin-stimulated autophosphorylation or phosphotransferase activity of the purified receptor. However, unlike the n...

journal_title：Cell

authors： White MF,Livingston JN,Backer JM,Lauris V,Dull TJ,Ullrich A,Kahn CR

更新日期：1988-08-26 00:00:00

abstract：:Muscle cell cultures from Drosophila melanogaster were obtained by plating dissociated gastrula stage embryo cells on protamine-treated culture dishes. They myogenic cells in these cultures fuse to form multinucleated pulsating cells by 15 hr after plating. An analysis of protein synthesis during myogenesis in these c...

journal_title：Cell

authors： Storti RV,Horovitch SJ,Scott MP,Rich A,Pardue ML

更新日期：1978-04-01 00:00:00

abstract：:Cellular functioning requires the orchestration of thousands of molecular interactions in time and space. Yet most molecules in a cell move by diffusion, which is sensitive to external factors like temperature. How cells sustain complex, diffusion-based systems across wide temperature ranges is unknown. Here, we uncov...

journal_title：Cell

authors： Persson LB,Ambati VS,Brandman O

更新日期：2020-12-10 00:00:00

abstract：:Multidrug resistance in human cells results from increased expression of the mdr1 (P-glycoprotein) gene. Although the same gene is activated in cells selected with different drugs, multidrug-resistant cell lines can be preferentially resistant to their selecting agent. The mdr1 cDNA sequence from vinblastine-selected ...

journal_title：Cell

authors： Choi KH,Chen CJ,Kriegler M,Roninson IB

更新日期：1988-05-20 00:00:00

abstract：:Clathrin-mediated endocytosis is a key mechanism by which cells take up extracellular cargo. In this issue, Shimada et al. (2007) reveal the mode of action of the F-BAR domain, which deepens the initial membrane pit that forms during clathrin-mediated endocytosis. ...

journal_title：Cell

authors： Fütterer K,Machesky LM

更新日期：2007-05-18 00:00:00

abstract：:The asymmetries of internal organs are consistently oriented along the left-right axis in all vertebrates, and perturbations of left-right orientation lead to significant congenital disease. We propose a model in which a "left-right coordinator" interacts with the Spemann organizer to coordinate the evolutionarily con...

journal_title：Cell

authors： Hyatt BA,Yost HJ

更新日期：1998-04-03 00:00:00

abstract：:Every day we make decisions critical for adaptation and survival. We repeat actions with known consequences. But we also draw on loosely related events to infer and imagine the outcome of entirely novel choices. These inferential decisions are thought to engage a number of brain regions; however, the underlying neuron...

journal_title：Cell

authors： Barron HC,Reeve HM,Koolschijn RS,Perestenko PV,Shpektor A,Nili H,Rothaermel R,Campo-Urriza N,O'Reilly JX,Bannerman DM,Behrens TEJ,Dupret D

更新日期：2020-10-01 00:00:00

abstract：:The germinal center (GC) reaction produces high-affinity antibodies by random mutation and selective clonal expansion of B cells with high-affinity receptors. The mechanism by which B cells are selected remains unclear, as does the role of the two anatomically defined areas of the GC, light zone (LZ) and dark zone (DZ...

journal_title：Cell

authors： Victora GD,Schwickert TA,Fooksman DR,Kamphorst AO,Meyer-Hermann M,Dustin ML,Nussenzweig MC

更新日期：2010-11-12 00:00:00

abstract：:In 1981, the acquired immunodeficiency syndrome (AIDS) appeared insidiously and mystified doctors and scientists alike. No one could have predicted then that it would become, arguably, the worst plague in human history. Today, 33 million persons are living with infection by the human immunodeficiency virus type 1 (HIV...

journal_title：Cell

authors： Ho DD,Bieniasz PD

更新日期：2008-05-16 00:00:00

abstract：:The large tumor antigen (LTag) of simian virus 40, an AAA(+) protein, is a hexameric helicase essential for viral DNA replication in eukaryotic cells. LTag functions as an efficient molecular machine powered by ATP binding and hydrolysis for origin DNA melting and replication fork unwinding. To understand how ATP bind...

journal_title：Cell

authors： Gai D,Zhao R,Li D,Finkielstein CV,Chen XS

更新日期：2004-10-01 00:00:00

abstract：:Proteolysis is a key regulatory process that promotes the (in)activation, translocation, and/or degradation of proteins. As such, there is considerable interest in methods to comprehensively characterize proteolytic pathways in biological systems. Here, we describe a robust and versatile proteomic platform that enable...

journal_title：Cell

authors： Dix MM,Simon GM,Cravatt BF

更新日期：2008-08-22 00:00:00

abstract：:At anaphase onset, the protease separase triggers chromosome segregation by cleaving the chromosomal cohesin complex. Here, we show that cohesin destruction in metaphase is sufficient for segregation of much of the budding yeast genome, but not of the long arm of chromosome XII that contains the rDNA repeats. rDNA in ...

journal_title：Cell

authors： Sullivan M,Higuchi T,Katis VL,Uhlmann F

更新日期：2004-05-14 00:00:00