The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice.

abstract：:Mutations in four nuclear genes, kar1 cdc4, 28, and 37, block or impair nuclear fusion during conjugation of Saccharomyces cerevisiae. Mutations in all four genes are recessive for the caryogamy defect; in matings between diploid cells both of which are heterozygous for any one of the four mutations (-/+ X -/+), caryo...

journal_title：Cell

authors： Dutcher SK,Hartwell LH

更新日期：1983-05-01 00:00:00

abstract：:The topology of E. coli inner membrane proteins depends primarily on the distribution of positively charged residues in the molecule. We have constructed model proteins with four potential transmembrane stretches and have systematically explored the topological effects of lysines placed in the loops connecting the tra...

journal_title：Cell

authors： Gafvelin G,von Heijne G

更新日期：1994-05-06 00:00:00

abstract：:We have located the distal boundary of the tyrosine kinase domain of the EGF receptor and have identified a distinct sequence in the C' terminus required for EGF-dependent receptor internalization, leading to receptor down-regulation and degradation. Within this receptor domain, an 18 amino acid highly negatively char...

journal_title：Cell

authors： Chen WS,Lazar CS,Lund KA,Welsh JB,Chang CP,Walton GM,Der CJ,Wiley HS,Gill GN,Rosenfeld MG

更新日期：1989-10-06 00:00:00

abstract：:All-trans retinoic acid (RA) has previously been shown to modulate the transcriptional properties of the retinoic acid receptor (RAR) and retinoid X receptor (RXR). The inability of all-trans RA to bind to RXR suggests that it may be metabolized to a more active high affinity ligand. We report here an experimental app...

journal_title：Cell

authors： Heyman RA,Mangelsdorf DJ,Dyck JA,Stein RB,Eichele G,Evans RM,Thaller C

更新日期：1992-01-24 00:00:00

abstract：:The plant innate immune response includes the hypersensitive response (HR), a form of programmed cell death (PCD). PCD must be restricted to infection sites to prevent the HR from playing a pathologic rather than protective role. Here we show that plant BECLIN 1, an ortholog of the yeast and mammalian autophagy gene A...

journal_title：Cell

authors： Liu Y,Schiff M,Czymmek K,Tallóczy Z,Levine B,Dinesh-Kumar SP

更新日期：2005-05-20 00:00:00

abstract：:Symbiotic bacteria are important in animal hosts, but have been largely overlooked as they have proved difficult to culture in the laboratory. Approaches such as comparative genomics and real-time PCR have provided insights into the molecular mechanisms that underpin symbiont-host interactions. Studies on the heritabl...

journal_title：Cell

authors： Dale C,Moran NA

更新日期：2006-08-11 00:00:00

abstract：:Transcriptional analysis of SV40 late promoter mutants indicates that the DNA sequence 5'-GGTACCTAACC-3' (map positions 294-304) is important in the control of SV40 late RNA expression. C to T base substitutions at map positions 298, 299 and 304 increased initiation of late RNA synthesis at map position 325 five to te...

journal_title：Cell

authors： Brady J,Radonovich M,Vodkin M,Natarajan V,Thoren M,Das G,Janik J,Salzman NP

更新日期：1982-12-01 00:00:00

abstract：:M-MuLV-specific DNA probes were used to establish the state of integration and amplification of recombinant proviral sequences in Moloney virus-induced tumors of Balb/Mo, Balb/c and 129 mice. The somatically acquired viral sequences contain both authentic M-MuLV genomes and recombinants of M-MuLV with endogenous viral...

journal_title：Cell

authors： van der Putten H,Quint W,van Raaij J,Maandag ER,Verma IM,Berns A

更新日期：1981-06-01 00:00:00

abstract：:The cis-trans isomerization of proline serves as a regulatory switch in signaling pathways. We identify the proline isomerase Fpr4, a member of the FK506 binding protein family in Saccharomyces cerevisiae, as an enzyme which binds the amino-terminal tail of histones H3 and H4 and catalyses the isomerization of H3 prol...

journal_title：Cell

authors： Nelson CJ,Santos-Rosa H,Kouzarides T

更新日期：2006-09-08 00:00:00

abstract：:Much of our understanding of chromosome segregation is based on cell culture systems. Here, we examine the importance of the tissue environment for chromosome segregation by comparing chromosome segregation fidelity across several primary cell types in native and nonnative contexts. We discover that epithelial cells h...

journal_title：Cell

authors： Knouse KA,Lopez KE,Bachofner M,Amon A

更新日期：2018-09-20 00:00:00

abstract：:ATP-dependent proteases are vital to maintain cellular protein homeostasis. Here, we study the mechanisms of force generation and intersubunit coordination in the ClpXP protease from E. coli to understand how these machines couple ATP hydrolysis to mechanical protein unfolding. Single-molecule analyses reveal that pho...

journal_title：Cell

authors： Sen M,Maillard RA,Nyquist K,Rodriguez-Aliaga P,Pressé S,Martin A,Bustamante C

更新日期：2013-10-24 00:00:00

abstract：:We have performed in vitro kinetic analyses of transcription from the 5S gene promoter in order to resolve the rate-limiting events which lead to accurate transcription of the 5S RNA gene. We demonstrate that a rate-limiting intermediate can be formed during an extended incubation prior to initiation of transcription....

journal_title：Cell

authors： Bieker JJ,Martin PL,Roeder RG

更新日期：1985-01-01 00:00:00

abstract：:Social interactions occur between multiple individuals, but what is the detailed relationship between the neural dynamics across their brains? To address this question across timescales and levels of neural activity, we used wireless electrophysiology to simultaneously record from pairs of bats engaged in a wide range...

journal_title：Cell

authors： Zhang W,Yartsev MM

更新日期：2019-07-11 00:00:00

abstract：:A family of novel substrates was designed to enable the efficient accumulation of intermediates in site-specific recombination. Strategically placed nicks allow these "suicide substrates" to initiate the reaction but prevent its completion or reversal. Consequently, it has been possible to determine that lambda site-s...

journal_title：Cell

authors： Nunes-Düby SE,Matsumoto L,Landy A

更新日期：1987-08-28 00:00:00

abstract：:Pathogenic Vibrio cholerae remains a major human health concern. V. cholerae has a characteristic curved rod morphology, with a longer outer face and a shorter inner face. The mechanism and function of this curvature were previously unknown. Here, we identify and characterize CrvA, the first curvature determinant in V...

journal_title：Cell

authors： Bartlett TM,Bratton BP,Duvshani A,Miguel A,Sheng Y,Martin NR,Nguyen JP,Persat A,Desmarais SM,VanNieuwenhze MS,Huang KC,Zhu J,Shaevitz JW,Gitai Z

更新日期：2017-01-12 00:00:00

abstract：:DNA sequence analysis of a class I gene (Q10), which maps to the Qa2,3 locus in the C57BL/10 (H-2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library. Exon 5, in particular, has an unusual structure such that a polypeptide produc...

journal_title：Cell

authors： Mellor AL,Weiss EH,Kress M,Jay G,Flavell RA

更新日期：1984-01-01 00:00:00

abstract：:The Bcl-2 family proteins are key regulators of apoptosis in human diseases and cancers. Though known to block apoptosis, Bcl-2 promotes cell death through an undefined mechanism. Here, we show that Bcl-2 interacts with orphan nuclear receptor Nur77 (also known as TR3), which is required for cancer cell apoptosis indu...

journal_title：Cell

authors： Lin B,Kolluri SK,Lin F,Liu W,Han YH,Cao X,Dawson MI,Reed JC,Zhang XK

更新日期：2004-02-20 00:00:00

abstract：:The crystal structure of the β2-adrenergic receptor (β2AR) bound to the G protein adenylyl cyclase stimulatory G protein (Gs) captured the complex in a nucleotide-free state (β2AR-Gsempty). Unfortunately, the β2AR-Gsempty complex does not provide a clear explanation for G protein coupling specificity. Evidence from se...

journal_title：Cell

authors： Liu X,Xu X,Hilger D,Aschauer P,Tiemann JKS,Du Y,Liu H,Hirata K,Sun X,Guixà-González R,Mathiesen JM,Hildebrand PW,Kobilka BK

更新日期：2019-05-16 00:00:00

abstract：:Microbes that cause persistent infections (e.g., herpes viruses) do so by switching from fast-growing lytic states to slow-growing latent states. Waldman et al. have identified a single transcription factor that governs the switch between the lytic and latent forms of Toxoplasma gondii, a parasite that causes a persis...

journal_title：Cell

authors： Kochanowsky JA,Koshy AA

更新日期：2020-01-23 00:00:00

abstract：:Conversion of glial cells into functional neurons represents a potential therapeutic approach for replenishing neuronal loss associated with neurodegenerative diseases and brain injury. Previous attempts in this area using expression of transcription factors were hindered by the low conversion efficiency and failure o...

journal_title：Cell

authors： Zhou H,Su J,Hu X,Zhou C,Li H,Chen Z,Xiao Q,Wang B,Wu W,Sun Y,Zhou Y,Tang C,Liu F,Wang L,Feng C,Liu M,Li S,Zhang Y,Xu H,Yao H,Shi L,Yang H

更新日期：2020-04-30 00:00:00

abstract：:The pandemic has impacted every scientist differently. Many negative impacts are frequently discussed. Here we highlight unexpected positives that we have found and hope will persist: improved access to experts; deeper and broader human engagement among colleagues, collaborators, and competitors; and significant democ...

journal_title：Cell

authors： Arturo EC,Saphire EO

更新日期：2020-10-01 00:00:00

abstract：:A plasmid containing the major late promoter was assembled into nucleosomes in a Xenopus oocyte extract, isolated by gel filtration, and found to be refractory to transcription initiation in vitro. However, exposure of the promoter to HeLa nuclear extract or to a mixture of isolated transcription factors prior to nucl...

journal_title：Cell

authors： Workman JL,Roeder RG

更新日期：1987-11-20 00:00:00

abstract：:Characterizing cell surface receptors mediating viral infection is critical for understanding viral tropism and developing antiviral therapies. Nevertheless, due to challenges associated with detecting protein interactions on the cell surface, the host receptors of many human pathogens remain unknown. Here, we build a...

journal_title：Cell

authors： Martinez-Martin N,Marcandalli J,Huang CS,Arthur CP,Perotti M,Foglierini M,Ho H,Dosey AM,Shriver S,Payandeh J,Leitner A,Lanzavecchia A,Perez L,Ciferri C

更新日期：2018-08-23 00:00:00

abstract：:Trypanosoma brucei variant surface glycoprotein (VSG) genes are activated either by duplicative (DA) transposition of the gene to a pre-activated expression site or by nonduplicative (NDA) activation of a previously silent telomeric gene. We have obtained a recombinant clone spanning the 5' barren region of the expres...

journal_title：Cell

authors： Cully DF,Ip HS,Cross GA

更新日期：1985-08-01 00:00:00

abstract：:A family of proteins was shown to bind cooperatively with TFIID to core promoters, as previously demonstrated for the general initiation factor TFIIA. These factors form distinct complexes with TFIID, fail to bind DNA in the absence of TFIID, differ chromatographically from TFIIA, and compete with TFIIA for binding to...

journal_title：Cell

authors： Meisterernst M,Roeder RG

更新日期：1991-11-01 00:00:00

abstract：:The fluid-mosaic model posits a liquid-like plasma membrane, which can flow in response to tension gradients. It is widely assumed that membrane flow transmits local changes in membrane tension across the cell in milliseconds, mediating long-range signaling. Here, we show that propagation of membrane tension occurs qu...

journal_title：Cell

authors： Shi Z,Graber ZT,Baumgart T,Stone HA,Cohen AE

更新日期：2018-12-13 00:00:00

abstract：:How metazoan mechanotransduction channels sense mechanical stimuli is not well understood. The NOMPC channel in the transient receptor potential (TRP) family, a mechanotransduction channel for Drosophila touch sensation and hearing, contains 29 Ankyrin repeats (ARs) that associate with microtubules. These ARs have bee...

journal_title：Cell

authors： Zhang W,Cheng LE,Kittelmann M,Li J,Petkovic M,Cheng T,Jin P,Guo Z,Göpfert MC,Jan LY,Jan YN

更新日期：2015-09-10 00:00:00

abstract：:From a transplantable mouse teratoma it has been possible to derive an established keratinizing cell line (XB) which grows well in cultures containing lethally irradiated 3T3 fibroblasts at the correct density. Single cells of the keratinizing line grow into colonies each consisting of a stratified squamous epithelium...

journal_title：Cell

authors： Rheinwald JG,Green H

更新日期：1975-11-01 00:00:00

abstract：:The synthesis of histones and DNA was examined in BHK cells arrested in G1 by isoleucine starvation and in cells progressing into the S phase upon isoleucine refeeding. Approximately 2-3% of the cells were not arrested in G1 and synthesized DNA. The rate of synthesis of DNA and nucleosomal histones observed in cells s...

journal_title：Cell

authors： Tarnowka MA,Baglioni C,Basilico C

更新日期：1978-09-01 00:00:00

abstract：:The nucleotide sequences of the 3' termini of the DNA from four autonomous rodent parvoviruses have been determined. The terminus of each genome exists as a Y-shaped hairpin structure involving 115 or 116 nucleotides. The sequence of this region of DNA is highly conserved and shows no evidence of internal sequence het...

journal_title：Cell

authors： Astell CR,Smith M,Chow MB,Ward DC

更新日期：1979-07-01 00:00:00