Abstract：
:DNA sequence analysis of a class I gene (Q10), which maps to the Qa2,3 locus in the C57BL/10 (H-2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library. Exon 5, in particular, has an unusual structure such that a polypeptide product is unlikely to be anchored in the cell membrane. Our findings suggest that the two sequences are derived from allelic class I genes, which are nonpolymorphic, in contrast to H-2K allelic sequences from the same mice, and they may encode liver-specific polypeptides of unknown function. Our previous studies indicate that the Q10 gene is a potential donor gene for the generation of mutations at the H-2K locus by inter-gene transfer of genetic information. Thus the lack of polymorphism in class I genes at the Q10 locus implies either that they are not recipients for such exchanges or that selective pressure prevents the accumulation of mutations in genes at this locus.
journal_name
Celljournal_title
Cellauthors
Mellor AL,Weiss EH,Kress M,Jay G,Flavell RAdoi
10.1016/0092-8674(84)90082-5subject
Has Abstractpub_date
1984-01-01 00:00:00pages
139-44issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(84)90082-5journal_volume
36pub_type
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