Abstract：
:NF-kappa B is a nuclear protein, found only in cells that transcribe immunoglobulin light chain genes, that interacts with a defined site in the kappa immunoglobulin enhancer. This protein can be induced in pre-B cells by stimulation with bacterial lipopolysaccharide (LPS). The induction involves a posttranslational activation, and the combined action of LPS and cycloheximide causes a superinduction. An active phorbol ester also induces this factor, and with kinetics more rapid than those for LPS stimulation. Phorbol-ester-mediated induction of NF-kappa B was observed in a T cell line (Jurkat) and a nonlymphoid cell line (HeLa), and is therefore not restricted to B-lymphoid cells. We interpret these results to indicate that factors that control transcription of specific genes in specific cells may be activated by posttranslational modification of precursor factors present more widely.
journal_name
Celljournal_title
Cellauthors
Sen R,Baltimore Ddoi
10.1016/0092-8674(86)90807-xsubject
Has Abstractpub_date
1986-12-26 00:00:00pages
921-8issue
6eissn
0092-8674issn
1097-4172pii
0092-8674(86)90807-Xjournal_volume
47pub_type
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