Abstract：
:Synapse formation requires changes in cell morphology and the upregulation and localization of synaptic proteins. In the cerebellum, mossy fibers undergo extensive remodeling as they contact several granule cells and form complex, multisynaptic glomerular rosettes. Here we show that granule cells secrete factors that induce axon and growth cone remodeling in mossy fibers. This effect is blocked by the WNT antagonist, sFRP-1, and mimicked by WNT-7a, which is expressed by granule cells. WNT-7a also induces synapsin I clustering at remodeled areas of mossy fibers, a preliminary step in synaptogenesis. Wnt-7a mutant mice show a delay in the morphological maturation of glomerular rosettes and in the accumulation of synapsin I. We propose that WNT-7a can function as a synaptogenic factor.
journal_name
Celljournal_title
Cellauthors
Hall AC,Lucas FR,Salinas PCdoi
10.1016/s0092-8674(00)80689-3subject
Has Abstractpub_date
2000-03-03 00:00:00pages
525-35issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(00)80689-3journal_volume
100pub_type
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