Abstract：
:In developing organisms, spatially prescribed cell identities are thought to be determined by the expression levels of multiple genes. Quantitative tests of this idea, however, require a theoretical framework capable of exposing the rules and precision of cell specification over developmental time. We use the gap gene network in the early fly embryo as an example to show how expression levels of the four gap genes can be jointly decoded into an optimal specification of position with 1% accuracy. The decoder correctly predicts, with no free parameters, the dynamics of pair-rule expression patterns at different developmental time points and in various mutant backgrounds. Precise cellular identities are thus available at the earliest stages of development, contrasting the prevailing view of positional information being slowly refined across successive layers of the patterning network. Our results suggest that developmental enhancers closely approximate a mathematically optimal decoding strategy.
journal_name
Celljournal_title
Cellauthors
Petkova MD,Tkačik G,Bialek W,Wieschaus EF,Gregor Tdoi
10.1016/j.cell.2019.01.007subject
Has Abstractpub_date
2019-02-07 00:00:00pages
844-855.e15issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(19)30040-6journal_volume
176pub_type
杂志文章相关文献
CELL文献大全abstract：:The structural organization of the two closely related vitellogenin genes A1 and A2 has been determined and compared by electron microscopy. In both genes the mRNA-coding sequence of 6 kb is interrupted 33 times, leading to a total gene length of 21 kb for gene A1 and 16 kb for gene A2. Thus both genes have a mean exo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90239-1
更新日期：1980-05-01 00:00:00
abstract：:It has been puzzling that mammalian telomeric proteins, including TRF1, TRF2, tankyrase, and TIN2 have no recognized orthologs in budding yeast. Here, we describe a human protein, hRap1, that is an ortholog of the yeast telomeric protein, scRap1p. hRap1 has three conserved sequence motifs in common with scRap1, is loc...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80858-2
更新日期：2000-05-26 00:00:00
abstract：:Solute carrier (SLC) membrane transport proteins control essential physiological functions, including nutrient uptake, ion transport, and waste removal. SLCs interact with several important drugs, and a quarter of the more than 400 SLC genes are associated with human diseases. Yet, compared to other gene families of s...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2015.07.022
更新日期：2015-07-30 00:00:00
abstract：:Ebola virus (EBOV) remains a public health threat. We performed a longitudinal study of B cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection induced lasting EBOV-specific immunoglobulin G (IgG) antibodies, but their subclass composition changed over time, with IgG1 persisting, IgG3 r...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.04.036
更新日期：2019-05-30 00:00:00
abstract：:The JAK/STAT signaling pathway, renowned for its effects on cell proliferation and survival, is constitutively active in various human cancers, including ovarian. We have found that JAK and STAT are required to convert the border cells in the Drosophila ovary from stationary, epithelial cells to migratory, invasive ce...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00607-9
更新日期：2001-12-28 00:00:00
abstract：:We have investigated RNA recombination among poliovirus genomes by analyzing both intratypic and intertypic recombinant crosses involving the same defined genetic markers. Sequence analysis of the recombinant junctions of 13 nonsibling intertypic recombinants showed that intertypic RNA recombination is not site-specif...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90600-8
更新日期：1986-11-07 00:00:00
abstract：:In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2008.08.010
更新日期：2008-08-22 00:00:00
abstract：:Telomerase activity was demonstrated in cell-free extracts from S. cerevisiae through the use of a PCR-based assay. As expected, this activity was eliminated by RNase or phenol treatment of the extract and was dependent on dGTP and dTTP. Telomerase was not detected in extracts prepared from cells grown for approximate...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(05)80017-0
更新日期：1995-06-30 00:00:00
abstract：:Despite the obvious importance of epithelial stem cells in tissue homeostasis and tumorigenesis, little is known about their specific location or biological characteristics. Using 3H-thymidine labeling, we have identified a subpopulation of corneal epithelial basal cells, located in the peripheral cornea in a region c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90958-6
更新日期：1989-04-21 00:00:00
abstract：:Discs large (DLG) mediates the clustering of synaptic molecules. Here we demonstrate that synaptic localization of DLG itself is regulated by CaMKII. We show that DLG and CaMKII colocalize at synapses and exist in the same protein complex. Constitutively activated CaMKII phenocopied structural abnormalities of dlg mut...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81964-9
更新日期：1999-08-06 00:00:00
abstract：:Csm, a type III-A CRISPR-Cas interference complex, is a CRISPR RNA (crRNA)-guided RNase that also possesses target RNA-dependent DNase and cyclic oligoadenylate (cOA) synthetase activities. However, the structural features allowing target RNA-binding-dependent activation of DNA cleavage and cOA generation remain unkno...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.10.052
更新日期：2019-01-10 00:00:00
abstract：:The membrane fusion potential of influenza HA, like many viral membrane-fusion glycoproteins, is generated by proteolytic cleavage of a biosynthetic precursor. The three-dimensional structure of ectodomain of the precursor HA0 has been determined and compared with that of cleaved HA. The cleavage site is a prominent s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81771-7
更新日期：1998-10-30 00:00:00
abstract：:Enduring forms of synaptic plasticity and memory require new protein synthesis, but little is known about the underlying regulatory mechanisms. Here, we investigate the role of MAPK signaling in these processes. Conditional expression of a dominant-negative form of MEK1 in the postnatal murine forebrain inhibited ERK ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(04)00115-1
更新日期：2004-02-06 00:00:00
abstract：:Vascular permeability is frequently associated with inflammation and is triggered by a cohort of secreted permeability factors such as vascular endothelial growth factor (VEGF). Here, we show that the physiological vascular permeability that precedes implantation is directly controlled by progesterone receptor (PR) an...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.12.025
更新日期：2014-01-30 00:00:00
abstract：:Protein aggregation is linked with neurodegeneration and numerous other diseases by mechanisms that are not well understood. Here, we have analyzed the gain-of-function toxicity of artificial β sheet proteins that were designed to form amyloid-like fibrils. Using quantitative proteomics, we found that the toxicity of ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.11.050
更新日期：2011-01-07 00:00:00
abstract：:mRNA made in eukaryotic cells typically has a 3' poly(A) tail that is added posttranscriptionally. To investigate mechanisms by which 3' poly(A) is formed, we identified the genes for the two vaccina virus-encoded polypeptides, VP55 and VP39. Primer-dependent polyadenylation activity was associated exclusively with pu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90048-4
更新日期：1991-09-20 00:00:00
abstract：:An attenuated form of familial adenomatous polyposis coli, AAPC, causes relatively few colonic polyps, but still carries a significant risk of colon cancer. The mutant alleles responsible for this attenuated phenotype have been mapped in several families to the adenomatous polyposis coli (APC) locus on human chromosom...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90538-2
更新日期：1993-12-03 00:00:00
abstract：:Sexual reproduction is almost universal in eukaryotic life and involves the fusion of male and female haploid gametes into a diploid cell. The sperm-restricted single-pass transmembrane protein HAP2-GCS1 has been postulated to function in membrane merger. Its presence in the major eukaryotic taxa-animals, plants, and ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.01.024
更新日期：2017-02-23 00:00:00
abstract：:Many neural progenitors, including Drosophila mushroom body (MB) and projection neuron (PN) neuroblasts, sequentially give rise to different subtypes of neurons throughout development. We identified a novel BTB-zinc finger protein, named Chinmo (Chronologically inappropriate morphogenesis), that governs neuronal tempo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.08.045
更新日期：2006-10-20 00:00:00
abstract：:We have obtained the complete sequence of cloned full-length DNA (NS DNA) derived from influenza virus gene 8, which codes for two unique polypeptides, NS1 and NS2, and the sequence of the NS2 mRNA. Previously we showed that the mRNA for NS1 (approximately 860 nucleotides) is colinear with the viral RNA and maps from ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90484-5
更新日期：1980-09-01 00:00:00
abstract：:E. coli sigma 54 protein confers on promoters containing its recognition sequence the ability to be activated from distant DNA sites. Its functional domains include two leucine zipper motifs, an acidic region, and a glutamine-rich domain. Several domains were disrupted and the assembly of mutant transcription complexe...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90269-k
更新日期：1990-09-07 00:00:00
abstract：:Nerve regeneration and developmental outgrowth of axons are both correlated with increased synthesis of an axonal membrane protein designated GAP-43. Phosphorylation of an apparently identical protein, present at lower abundance in adult brains, has been correlated with long-term potentiation, a form of synaptic plast...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90616-7
更新日期：1987-06-19 00:00:00
abstract：:Activation of plasma membrane calcium channels by depletion of endoplasmic reticulum (ER) calcium stores is important for calcium entry in many cell types. Park et al. (2009) now show that direct binding of the ER protein STIM to tetramers of the Orai1 calcium channel in the plasma membrane triggers opening of this ch...
journal_title：Cell
pub_type： 评论,社论
doi：10.1016/j.cell.2009.02.022
更新日期：2009-03-06 00:00:00
abstract：:From the approximately 1,200 odorant receptor (OR) genes in the mouse genome, an olfactory sensory neuron is thought to express only one gene. The mechanisms of OR gene choice are not understood. A 2.1 kilobase region (the H element) adjacent to a cluster of seven OR genes has been proposed as a trans- and pan-enhance...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.06.023
更新日期：2007-07-27 00:00:00
abstract：:The PML tumor suppressor controls key pathways for growth suppression, induction of apoptosis, and cellular senescence. PML loss occurs frequently in human tumors through unknown posttranslational mechanisms. Casein kinase 2 (CK2) is oncogenic and frequently upregulated in human tumors. Here we show that CK2 regulates...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.05.041
更新日期：2006-07-28 00:00:00
abstract：:We show that a functional component of the C. elegans mitotic machinery regulates X chromosome gene expression. This protein, MIX-1, is a member of the dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene expression during interphase. MIX-1 also associates with...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80920-4
更新日期：1998-01-23 00:00:00
abstract：:The influence of MHC antigens on TCR gamma delta usage in CD8+ intraepithelial lymphocytes (IELs) was examined using a pan-reactive and V delta 4 region-specific MAb. While an average of 30% of IELs from the majority of mice of various MHC haplotypes were V delta 4+, a 2-fold or greater percentage of IELs from H-2k mi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90166-c
更新日期：1990-10-19 00:00:00
abstract：:NPR1 is an essential regulator of plant systemic acquired resistance (SAR), which confers immunity to a broad-spectrum of pathogens. SAR induction results in accumulation of the signal molecule salicylic acid (SA), which induces defense gene expression via activation of NPR1. We found that in an uninduced state, NPR1 ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00429-x
更新日期：2003-06-27 00:00:00
abstract：:During RNA interference (RNAi), Dicer generates short interfering RNAs (siRNAs), which then guide target mRNA cleavage by the RISC complex. Now, Liu et al. identify R2D2, a Dicer-associated protein that is important for siRNA incorporation into RISC, thus linking the initiation and execution phases of RNAi. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00806-7
更新日期：2003-10-17 00:00:00
abstract：:In familial searching in forensic genetics, a query DNA profile is tested against a database to determine whether it represents a relative of a database entrant. We examine the potential for using linkage disequilibrium to identify pairs of profiles as belonging to relatives when the query and database rely on nonover...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.09.008
更新日期：2018-10-18 00:00:00
