Extrathymic selection of TCR gamma delta + T cells by class II major histocompatibility complex molecules.

abstract：:The low-complexity (LC) domains of the products of the fused in sarcoma (FUS), Ewings sarcoma (EWS), and TAF15 genes are translocated onto a variety of different DNA-binding domains and thereby assist in driving the formation of cancerous cells. In the context of the translocated fusion proteins, these LC sequences fu...

journal_title：Cell

authors： Kwon I,Kato M,Xiang S,Wu L,Theodoropoulos P,Mirzaei H,Han T,Xie S,Corden JL,McKnight SL

更新日期：2013-11-21 00:00:00

abstract：:cDNA clones of the Drosophila epidermal growth factor receptor homolog (DER) gene were isolated and sequenced. The deduced amino acid sequence shows a similar degree of homology to the human epidermal growth factor receptor and to the rat and human neu proteins; the most striking difference is the addition of a third ...

journal_title：Cell

authors： Schejter ED,Segal D,Glazer L,Shilo BZ

更新日期：1986-09-26 00:00:00

abstract：:Chromosome segregation at meiosis I depends on pairing and crossing-over between homologs. In most eukaryotes, pairing culminates with formation of the proteinaceous synaptonemal complex (SC). In budding yeast, recombination initiates through double-strand DNA breaks (DSBs) and is thought to be essential for SC format...

journal_title：Cell

authors： Dernburg AF,McDonald K,Moulder G,Barstead R,Dresser M,Villeneuve AM

更新日期：1998-08-07 00:00:00

abstract：:Cellular receptors are required for efficient entry of retroviruses into cells. We previously cloned a chicken gene responsible for susceptibility to the retrovirus subgroup A Rous sarcoma virus (RSV(A)). Here we have isolated the quail homolog and generated two alternatively spliced processed genes encoding cellular ...

journal_title：Cell

authors： Bates P,Young JA,Varmus HE

更新日期：1993-09-24 00:00:00

abstract：:The tyrT locus of E. coli contains a 208 bp spacer region that separates two copies of sequence encoding tRNATyr1. The spacer includes a 120 bp sequence that is homologous to a sequence that is repeated three times in the distal portion of the tyrT locus. The tyrT locus possesses a graded set of transcription terminat...

journal_title：Cell

authors： Rossi J,Egan J,Hudson L,Landy A

更新日期：1981-11-01 00:00:00

abstract：:Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skeletal and cardiac mu...

journal_title：Cell

authors： Tisdale MJ

更新日期：2010-08-20 00:00:00

abstract：:The small ribosomal subunit performs the decoding of genetic information during translation. The structure of that from Thermus thermophilus shows that the decoding center, which positions mRNA and three tRNAs, is constructed entirely of RNA. The entrance to the mRNA channel will encircle the message when a latch-like...

journal_title：Cell

authors： Schluenzen F,Tocilj A,Zarivach R,Harms J,Gluehmann M,Janell D,Bashan A,Bartels H,Agmon I,Franceschi F,Yonath A

更新日期：2000-09-01 00:00:00

abstract：:To guide the design of immunotherapy strategies for patients with early stage lung tumors, we developed a multiscale immune profiling strategy to map the immune landscape of early lung adenocarcinoma lesions to search for tumor-driven immune changes. Utilizing a barcoding method that allows a simultaneous single-cell ...

journal_title：Cell

authors： Lavin Y,Kobayashi S,Leader A,Amir ED,Elefant N,Bigenwald C,Remark R,Sweeney R,Becker CD,Levine JH,Meinhof K,Chow A,Kim-Shulze S,Wolf A,Medaglia C,Li H,Rytlewski JA,Emerson RO,Solovyov A,Greenbaum BD,Sanders C,Vi

更新日期：2017-05-04 00:00:00

abstract：:Iron is ubiquitous in the environment and in biology. The study of iron biology focuses on physiology and homeostasis-understanding how cells and organisms regulate their iron content, how diverse tissues orchestrate iron allocation, and how dysregulated iron homeostasis leads to common hematological, metabolic, and n...

journal_title：Cell

authors： Hentze MW,Muckenthaler MU,Andrews NC

更新日期：2004-04-30 00:00:00

abstract：:Cellular functioning requires the orchestration of thousands of molecular interactions in time and space. Yet most molecules in a cell move by diffusion, which is sensitive to external factors like temperature. How cells sustain complex, diffusion-based systems across wide temperature ranges is unknown. Here, we uncov...

journal_title：Cell

authors： Persson LB,Ambati VS,Brandman O

更新日期：2020-12-10 00:00:00

abstract：:The glucocorticoid receptor is a signal transducer that interacts both with the signal and with the genes it regulates. We showed previously that nuclear localization of the receptor requires hormone binding. We have now constructed recombinant receptors that relieve hormonal control of nuclear localization, and we de...

journal_title：Cell

authors： Picard D,Salser SJ,Yamamoto KR

更新日期：1988-09-23 00:00:00

abstract：:DNA sequence analysis of a class I gene (Q10), which maps to the Qa2,3 locus in the C57BL/10 (H-2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library. Exon 5, in particular, has an unusual structure such that a polypeptide produc...

journal_title：Cell

authors： Mellor AL,Weiss EH,Kress M,Jay G,Flavell RA

更新日期：1984-01-01 00:00:00

abstract：:Social interactions occur between multiple individuals, but what is the detailed relationship between the neural dynamics across their brains? To address this question across timescales and levels of neural activity, we used wireless electrophysiology to simultaneously record from pairs of bats engaged in a wide range...

journal_title：Cell

authors： Zhang W,Yartsev MM

更新日期：2019-07-11 00:00:00

abstract：:Mutations in gurken and torpedo cause a ventralization in the follicle cell epithelium during Drosophila oogenesis and in the pattern of the embryo that develops in the resultant egg. Both genes lie midway in an epistatic series between fs(1)K10 and dorsal; the mutations block the dorsalization normally observed in K1...

journal_title：Cell

authors： Schüpbach T

更新日期：1987-06-05 00:00:00

abstract：:Cancer immunotherapy can induce long lasting responses in patients with metastatic cancers of a wide range of histologies. Broadening the clinical applicability of these treatments requires an improved understanding of the mechanisms limiting cancer immunotherapy. The interactions between the immune system and cancer ...

journal_title：Cell

authors： Sharma P,Hu-Lieskovan S,Wargo JA,Ribas A

更新日期：2017-02-09 00:00:00

abstract：:A paradigm for control of insulin secretion is that glucose metabolism elevates cytoplasmic [ATP]/[ADP] in beta cells, closing K(ATP) channels and causing depolarization, Ca2+ entry, and insulin release. Decreased responsiveness of K(ATP) channels to elevated [ATP]/[ADP] should therefore lead to decreased insulin secr...

journal_title：Cell

authors： Koster JC,Marshall BA,Ensor N,Corbett JA,Nichols CG

更新日期：2000-03-17 00:00:00

abstract：:The brlA gene of A. nidulans mediates the developmental switch from the indeterminate, apical growth pattern of vegetative cells to the budding growth pattern of conidiophores. brlA encodes a 432 amino acid polypeptide containing two directly repeated motifs resembling the Zn(II) coordination sites first recognized in...

journal_title：Cell

authors： Adams TH,Boylan MT,Timberlake WE

更新日期：1988-07-29 00:00:00

abstract：:Hunger and thirst have distinct goals but control similar ingestive behaviors, and little is known about neural processes that are shared between these behavioral states. We identify glutamatergic neurons in the peri-locus coeruleus (periLCVGLUT2 neurons) as a polysynaptic convergence node from separate energy-sensiti...

journal_title：Cell

authors： Gong R,Xu S,Hermundstad A,Yu Y,Sternson SM

更新日期：2020-09-17 00:00:00

abstract：:The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Here, we identify induction of glucocorticoid receptor (GR) expression as a common feature of drug-resistant tumors in a credentialed preclinical model, a finding also confirmed in patient samples. GR s...

journal_title：Cell

authors： Arora VK,Schenkein E,Murali R,Subudhi SK,Wongvipat J,Balbas MD,Shah N,Cai L,Efstathiou E,Logothetis C,Zheng D,Sawyers CL

更新日期：2013-12-05 00:00:00

abstract：:The rate-limiting enzyme of cholesterol biosynthesis, HMG CoA reductase, is controlled by negative feedback regulation of transcription. We have isolated the reductase gene from a bacteriophage lambda genomic library prepared from hamster UT-1 cells. The 25 kilobase gene is split into 20 exons. The 5' untranslated and...

journal_title：Cell

authors： Reynolds GA,Basu SK,Osborne TF,Chin DJ,Gil G,Brown MS,Goldstein JL,Luskey KL

更新日期：1984-08-01 00:00:00

abstract：:Synaptic plasticity in response to changes in physiologic state is coordinated by hormonal signals across multiple neuronal cell types. Here, we combine cell-type-specific electrophysiological, pharmacological, and optogenetic techniques to dissect neural circuits and molecular pathways controlling synaptic plasticity...

journal_title：Cell

authors： Yang Y,Atasoy D,Su HH,Sternson SM

更新日期：2011-09-16 00:00:00

abstract：:How cells generate a single axis of polarity for mating, division, and movement is unknown. In this issue, Howell et al. (2009) use a synthetic biology approach to demonstrate that rapid competition for a soluble signaling component (Bem1) is essential to ensure a unique axis of polarity in budding yeast. ...

journal_title：Cell

authors： Houk AR,Millius A,Weiner OD

更新日期：2009-11-13 00:00:00

abstract：:The exchange of metabolites between the mitochondrial matrix and the cytosol depends on β-barrel channels in the outer membrane and α-helical carrier proteins in the inner membrane. The essential translocase of the inner membrane (TIM) chaperones escort these proteins through the intermembrane space, but the structura...

journal_title：Cell

authors： Weinhäupl K,Lindau C,Hessel A,Wang Y,Schütze C,Jores T,Melchionda L,Schönfisch B,Kalbacher H,Bersch B,Rapaport D,Brennich M,Lindorff-Larsen K,Wiedemann N,Schanda P

更新日期：2018-11-15 00:00:00

abstract：:An attenuated form of familial adenomatous polyposis coli, AAPC, causes relatively few colonic polyps, but still carries a significant risk of colon cancer. The mutant alleles responsible for this attenuated phenotype have been mapped in several families to the adenomatous polyposis coli (APC) locus on human chromosom...

journal_title：Cell

authors： Spirio L,Olschwang S,Groden J,Robertson M,Samowitz W,Joslyn G,Gelbert L,Thliveris A,Carlson M,Otterud B

更新日期：1993-12-03 00:00:00

abstract：:A single mouse blastomere from an embryo until the 8-cell stage can generate an entire blastocyst. Whether laboratory-cultured cells retain a similar generative capacity remains unknown. Starting from a single stem cell type, extended pluripotent stem (EPS) cells, we established a 3D differentiation system that enable...

journal_title：Cell

authors： Li R,Zhong C,Yu Y,Liu H,Sakurai M,Yu L,Min Z,Shi L,Wei Y,Takahashi Y,Liao HK,Qiao J,Deng H,Nuñez-Delicado E,Rodriguez Esteban C,Wu J,Izpisua Belmonte JC

更新日期：2019-10-17 00:00:00

abstract：:A Drosophila gene with similarity to the mammalian Ras GTPase activating protein has been isolated in screens for mutations that affect eye development. Inactivation of the locus, Gap1, mimics constitutive activation of the Sevenless receptor tyrosine kinase and eliminates the need for a functional Sevenless protein i...

journal_title：Cell

authors： Gaul U,Mardon G,Rubin GM

更新日期：1992-03-20 00:00:00

abstract：:An approach to identify backbone conformational changes underlying nicotinic acetylcholine receptor (nAChR) gating was developed. Specific backbone peptide bonds were replaced with an ester, which disrupts backbone hydrogen bonds at the site of mutation. At a conserved proline residue (alphaPro221) in the first transm...

journal_title：Cell

authors： England PM,Zhang Y,Dougherty DA,Lester HA

更新日期：1999-01-08 00:00:00

abstract：:Lineage tracing is the identification of all progeny of a single cell. Although its origins date back to developmental biology of invertebrates in the 19(th) century, lineage tracing is now an essential tool for studying stem cell properties in adult mammalian tissues. Lineage tracing provides a powerful means of unde...

journal_title：Cell

authors： Kretzschmar K,Watt FM

更新日期：2012-01-20 00:00:00

abstract：:ATP-dependent proteases are vital to maintain cellular protein homeostasis. Here, we study the mechanisms of force generation and intersubunit coordination in the ClpXP protease from E. coli to understand how these machines couple ATP hydrolysis to mechanical protein unfolding. Single-molecule analyses reveal that pho...

journal_title：Cell

authors： Sen M,Maillard RA,Nyquist K,Rodriguez-Aliaga P,Pressé S,Martin A,Bustamante C

更新日期：2013-10-24 00:00:00

abstract：:Transplantation of pronuclei between one-cell-stage embryos was used to construct diploid mouse embryos with two female pronuclei ( biparental gynogenones ) or two male pronuclei ( biparental androgenones ). The ability of these embryos to develop to term was compared with control nuclear-transplant embryos in which t...

journal_title：Cell

authors： McGrath J,Solter D

更新日期：1984-05-01 00:00:00