Abstract：
:Iron is ubiquitous in the environment and in biology. The study of iron biology focuses on physiology and homeostasis-understanding how cells and organisms regulate their iron content, how diverse tissues orchestrate iron allocation, and how dysregulated iron homeostasis leads to common hematological, metabolic, and neurodegenerative diseases. This has provided novel insights into gene regulation and unveiled remarkable links to the immune system.
journal_name
Celljournal_title
Cellauthors
Hentze MW,Muckenthaler MU,Andrews NCdoi
10.1016/s0092-8674(04)00343-5subject
Has Abstractpub_date
2004-04-30 00:00:00pages
285-97issue
3eissn
0092-8674issn
1097-4172pii
S0092867404003435journal_volume
117pub_type
杂志文章,评审相关文献
CELL文献大全abstract：:Cardiomyocytes, the cells of the heart muscle, lose nearly all of their proliferative capacity after birth, limiting the heart's ability to regenerate. Naqvi et al. now identify a transient burst of cardiomyocyte proliferation during preadolescence, driven by a thyroid hormone surge, with therapeutic implications for ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2014.04.025
更新日期：2014-05-08 00:00:00
abstract：:In the SV40-transformed mouse embryo fibroblast cell line SVT2/S, genomic rearrangements involving the SV40 DNA and flanking host sequences were identified by Southern blot hybridization using viral DNA as probe. No rearrangements of SV40 DNA integrated into nonpermissive mouse cells have been previously described. Th...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90268-3
更新日期：1981-01-01 00:00:00
abstract：:We have produced a series of somatic cell hybrids by fusing pluripotent PCC4aza1 embryonal carcinoma ("teretocarcinoma") cells with thymocytes from young adult mice. When these hybrids form tumors in nu/nu or syngeneic mice, all the tumors contain a range of differentiated tissues, as well as embryonal carcinoma-like ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90051-9
更新日期：1976-09-01 00:00:00
abstract：:We have cloned and characterized the rat telomerase protein component 1 gene (TLP1), which is related to the gene for Tetrahymena p80. The cDNA encodes a 2629 amino acid sequence and produces the TLP1 proteins p240 and p230. The anti-TLP1 antibody specifically immunoprecipitated the telomerase activity. Moreover, p240...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81933-9
更新日期：1997-03-21 00:00:00
abstract：:M-MuLV-specific DNA probes were used to establish the state of integration and amplification of recombinant proviral sequences in Moloney virus-induced tumors of Balb/Mo, Balb/c and 129 mice. The somatically acquired viral sequences contain both authentic M-MuLV genomes and recombinants of M-MuLV with endogenous viral...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90099-4
更新日期：1981-06-01 00:00:00
abstract：:We have analyzed the viral DNA sequences persisting in HE C19, a clonal line of hamster embryo cells transformed in vitro by human adenovirus 12 (Ad 12), a member of highly oncogenic group A. Saturation-hybridization of in vitro labeled Ad 12 DNA (2-4 x 10(8) cpm/mug) with HE C19 DNA showed that 93-100% of viral DNA s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90172-0
更新日期：1976-03-01 00:00:00
abstract：:Dimerization-driven activation of the intracellular kinase domains of the epidermal growth factor receptor (EGFR) upon extracellular ligand binding is crucial to cellular pathways regulating proliferation, migration, and differentiation. Inactive EGFR can exist as both monomers and dimers, suggesting that the mechanis...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.12.030
更新日期：2013-01-31 00:00:00
abstract：:The brain produces two brain-derived neurotrophic factor (BDNF) transcripts, with either short or long 3' untranslated regions (3' UTRs). The physiological significance of the two forms of mRNAs encoding the same protein is unknown. Here, we show that the short and long 3' UTR BDNF mRNAs are involved in different cell...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.05.045
更新日期：2008-07-11 00:00:00
abstract：:A second and minor DNA component containing 5s RNA genes has been purified from the genomic DNA of Xenopus laevis (XIt 5S DNA). Some of its physical and chemical characteristics are described. It contains a 5S RNA gene sequence which has some oocyte and some somatic-specific residues, as well as nucleotides which diff...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(77)90168-4
更新日期：1977-12-01 00:00:00
abstract：:Most human epithelial tumors harbor numerous alterations, making it difficult to predict which genes are required for tumor survival. To systematically identify cancer dependencies, we analyzed 501 genome-scale loss-of-function screens performed in diverse human cancer cell lines. We developed DEMETER, an analytical f...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.06.010
更新日期：2017-07-27 00:00:00
abstract：:Stem cells are highly resistant to viral infection compared to their differentiated progeny; however, the mechanism is mysterious. Here, we analyzed gene expression in mammalian stem cells and cells at various stages of differentiation. We find that, conserved across species, stem cells express a subset of genes previ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.11.018
更新日期：2018-01-25 00:00:00
abstract：:Sir2 is a conserved deacetylase that modulates life span in yeast, worms, and flies and stress response in mammals. In yeast, Sir2 is required for maintaining replicative life span, and increasing Sir2 dosage can delay replicative aging. We address the role of Sir2 in regulating chronological life span in yeast. Lack ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.08.042
更新日期：2005-11-18 00:00:00
abstract：:We have identified a gene, SRV2, mutations of which alleviate stress sensitivity in strains carrying an activated RAS gene. Epistasis analysis suggests that the gene affects accumulation of cAMP in the cell. Direct assays of cAMP accumulation indicate that mutations of the gene diminish the rate of in vivo production ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90813-t
更新日期：1990-04-20 00:00:00
abstract：:ROAM mutations cause overproduction in S. cerevisiae. Overproduction of ROAM mutant gene products is less in MATa/MAT alpha diploid strains which cannot conjugate than in haplolid strains which can. Overproduction occurs in diploid strains capable of mating whether or not they are capable of sporulating. Overproductio...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90353-0
更新日期：1980-11-01 00:00:00
abstract：:Dietary restriction (DR) extends lifespan in multiple species. To examine the mechanisms of lifespan extension upon DR, we assayed genome-wide translational changes in Drosophila. A number of nuclear encoded mitochondrial genes, including those in Complex I and IV of the electron transport chain, showed increased ribo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.07.034
更新日期：2009-10-02 00:00:00
abstract：:A gene, bcl-3, is found on chromosome 19 adjacent to the breakpoints in the translocation t(14;19)(q32;q13.1), which occurs in some cases of chronic lymphocytic leukemia. Sequence analysis of the human bcl-3 gene predicts a protein containing seven tandem copies of the SWI6/cdc10 motif. This motif was previously ident...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90347-h
更新日期：1990-03-23 00:00:00
abstract：:We describe a monoclonal antibody directed against a neuron-specific mitochondrial protein from rat brain. On protein blots the antibody recognizes a single polypeptide of apparent molecular weight of 23,000. By solid-phase immunoassay the antigen was detected in nonneural tissues. Within neurons, the antibody stains ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90343-9
更新日期：1982-02-01 00:00:00
abstract：:Nine transcripts complementary to mouse L cell mitochondrial DNA have been detected, sized and mapped to restriction fragments using the method of Berk and Sharp (1977). RNA isolated from L cell mitochondria was hybridized to 32P-labeled, cloned L cell mitochondrial DNA restriction fragments in 70% formamide under con...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90309-4
更新日期：1978-05-01 00:00:00
abstract：:The phosphoinositide 3-kinase related kinases (PIKKs) mediate responses to diverse stresses, including DNA double-strand breaks (DSBs), abnormal replication fork progression, the recognition of premature termination codons in mRNAs, and inadequate nutrient availability. Rigorous control of these kinases limits cellula...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2004.06.023
更新日期：2004-07-09 00:00:00
abstract：:Reversible protein phosphorylation is a signaling mechanism involved in all cellular processes. To create a systems view of the signaling apparatus in budding yeast, we generated an epistatic miniarray profile (E-MAP) comprised of 100,000 pairwise, quantitative genetic interactions, including virtually all protein and...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.12.039
更新日期：2009-03-06 00:00:00
abstract：:We have isolated cDNA clones generated from the mRNA encoding the opsin apoprotein of bovine rhodopsin and used these cDNAs to isolate genomic DNA clones containing the complete opsin gene. Nucleotide sequence analysis of the cloned DNAs has yielded a complete amino acid sequence for bovine rhodopsin and provided an i...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90537-8
更新日期：1983-10-01 00:00:00
abstract：:Type I spiral ganglion neurons (SGNs) transmit sound information from cochlear hair cells to the CNS. Using transcriptome analysis of thousands of single neurons, we demonstrate that murine type I SGNs consist of subclasses that are defined by the expression of subsets of transcription factors, cell adhesion molecules...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.07.008
更新日期：2018-08-23 00:00:00
abstract：:Most physiological functions originate with the communication between organs. Mouse genetics has revived this holistic view of physiology through the identification of inter-organ communications that are unanticipated, functionally important, and would have been difficult to uncover otherwise. This Review highlights t...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2016.02.043
更新日期：2016-03-10 00:00:00
abstract：:Secretory proteins are segregated from cytosolic proteins by their translocation into the endoplasmic reticulum (ER). A modified secretory protein trapped during translocation across the ER membrane can be crosslinked to two previously identified proteins, Sec61p and BiP (Kar2p). The dependence of this cross-linking u...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90415-9
更新日期：1992-04-17 00:00:00
abstract：:Two DNA sequences that reduce mitotic fidelity of chromosome transmission have been identified: MIF1 and MIF2. MIF1 is a unique sequence located on the right arm of chromosome XII that stimulates loss and recombination for both chromosomes V and VII when present in a high copy number plasmid. MIF1 is not essential for...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90484-8
更新日期：1986-01-17 00:00:00
abstract：:Nociceptin and its receptor are widely distributed throughout the brain in regions associated with reward behavior, yet how and when they act is unknown. Here, we dissected the role of a nociceptin peptide circuit in reward seeking. We generated a prepronociceptin (Pnoc)-Cre mouse line that revealed a unique subpopula...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.06.034
更新日期：2019-07-25 00:00:00
abstract：:We present evidence that the genes encoding U3 snRNA in plants are transcribed by RNA polymerase III (pol III) and not by RNA polymerase II (pol II) as in vertebrates or lower eukaryotes. The U3 gene is the only known example of a gene transcribed by different polymerases in different organisms. It is possible to conv...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90469-f
更新日期：1991-05-03 00:00:00
abstract：:The glucocorticoid receptor is a signal transducer that interacts both with the signal and with the genes it regulates. We showed previously that nuclear localization of the receptor requires hormone binding. We have now constructed recombinant receptors that relieve hormonal control of nuclear localization, and we de...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90122-5
更新日期：1988-09-23 00:00:00
abstract：:Nuclear exclusion of the forkhead transcription factor FOXO3a by protein kinase Akt contributes to cell survival. We investigated the pathological relationship between phosphoylated-Akt (Akt-p) and FOXO3a in primary tumors. Surprisingly, FOXO3a was found to be excluded from the nuclei of some tumors lacking Akt-p, sug...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(04)00302-2
更新日期：2004-04-16 00:00:00
abstract：:Deletion analysis was carried out on the human 7SK RNA gene to map regions essential for in vitro transcription by RNA polymerase III. The sequence promoting transcription is located between 37 and 3 bp upstream of the 7SK RNA coding region. RNA polymerase III transcription of adjacent plasmid sequences can be directe...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90012-2
更新日期：1987-10-09 00:00:00
