Genomic rearrangements in a mouse cell line containing integrated SV40 DNA.

abstract：:Hsp33, a member of a newly discovered heat shock protein family, was found to be a very potent molecular chaperone. Hsp33 is distinguished from all other known molecular chaperones by its mode of functional regulation. Its activity is redox regulated. Hsp33 is a cytoplasmically localized protein with highly reactive c...

journal_title：Cell

authors： Jakob U,Muse W,Eser M,Bardwell JC

更新日期：1999-02-05 00:00:00

abstract：:A 1.1 kb intron containing an open reading frame (ORF) in one allele (omega+) of the yeast mitochondrial 21S rRNA gene is nearly quantitatively inserted in crosses into a 21S rRNA allele lacking that intron (omega-). We have determined that this nonreciprocal exchange initiates soon after cells fuse to form zygotes an...

journal_title：Cell

authors： Zinn AR,Butow RA

更新日期：1985-04-01 00:00:00

abstract：:Who are science journalists, and how can journalists and research scientists work together to improve science communication? ...

journal_title：Cell

authors： Matheson S

更新日期：2016-11-17 00:00:00

abstract：:The mipA gene of A. nidulans encodes a newly discovered member of the tubulin superfamily of proteins, gamma-tubulin. In A. nidulans, gamma-tubulin is essential for nuclear division and microtubule assembly and is associated with the spindle pole body, the fungal microtubule organizing center. By low stringency hybrid...

journal_title：Cell

authors： Zheng Y,Jung MK,Oakley BR

更新日期：1991-05-31 00:00:00

abstract：:We mutated, by gene targeting, the endogenous hypoxanthine phosphoribosyl transferase (HPRT) gene in mouse embryo-derived stem (ES) cells. A specialized construct of the neomycin resistance (neor) gene was introduced into an exon of a cloned fragment of the Hprt gene and used to transfect ES cells. Among the G418r col...

journal_title：Cell

authors： Thomas KR,Capecchi MR

更新日期：1987-11-06 00:00:00

abstract：:Nucleotide sequences in two wild-type and six mutant operators in the DNA of phage lambda are compared. Strikingly similar 17 base pair units are found which we identify as the repressor binding sites. Each operator contains multiple repressor binding sites separated by A-T rich spacers. Elements of 2 fold rotational ...

journal_title：Cell

authors： Maniatis T,Ptashne M,Backman K,Kield D,Flashman S,Jeffrey A,Maurer R

更新日期：1975-06-01 00:00:00

abstract：:The HIV-1 matrix (MA) protein contains two subcellular localization signals with opposing effects. A myristoylated N-terminus governs particle assembly at the plasma membrane, and a nucleophilic motif facilitates import of the viral preintegration complex into the nucleus of nondividing cells. Here, we show that myris...

journal_title：Cell

authors： Gallay P,Swingler S,Aiken C,Trono D

更新日期：1995-02-10 00:00:00

abstract：:Endogenous and infectious mouse mammary tumor viruses (MMTVs) encode in their 3' long terminal repeat a protein that exerts superantigen activity; that is, it is able to interact with T cells via the variable domain of the T cell receptor (TCR) beta chain. We show here that transmission of an infectious MMTV is preven...

journal_title：Cell

authors： Held W,Waanders GA,Shakhov AN,Scarpellino L,Acha-Orbea H,MacDonald HR

更新日期：1993-08-13 00:00:00

abstract：:Spatiotemporal changes in nuclear lamina composition underlie cell-type-specific chromatin organization and cell fate, suggesting that the lamina forms a dynamic framework critical for genome function, cellular identity, and developmental potential. ...

journal_title：Cell

authors： Van Bortle K,Corces VG

更新日期：2013-03-14 00:00:00

abstract：:In prokaryotes, the toxin-antitoxin systems are thought to play important roles in growth regulation under stress conditions. In the E. coli MazE-MazF system, MazF toxin functions as an mRNA interferase cleaving mRNAs at ACA sequences to inhibit protein synthesis leading to cell growth arrest. Myxococcus xanthus is a ...

journal_title：Cell

authors： Nariya H,Inouye M

更新日期：2008-01-11 00:00:00

abstract：:Human cerebral cortex size and complexity has increased greatly during evolution. While increased progenitor diversity and enhanced proliferative potential play important roles in human neurogenesis and gray matter expansion, the mechanisms of human oligodendrogenesis and white matter expansion remain largely unknown....

journal_title：Cell

authors： Huang W,Bhaduri A,Velmeshev D,Wang S,Wang L,Rottkamp CA,Alvarez-Buylla A,Rowitch DH,Kriegstein AR

更新日期：2020-08-06 00:00:00

abstract：:Eukaryotic cells have developed mechanisms for regulating the nuclear transport of macromolecules that control various cellular events including movement through defined stages of the cell cycle. In yeast cells, where the nuclear envelope remains intact throughout the cell cycle, these transport regulatory mechanisms ...

journal_title：Cell

authors： Makhnevych T,Lusk CP,Anderson AM,Aitchison JD,Wozniak RW

更新日期：2003-12-26 00:00:00

abstract：:Nucleosomes positioned over promoters are usually inhibitory to protein binding and activity. We analyzed at the nucleotide level of resolution the nucleosomal organization of a distal, liver-specific enhancer in various mouse tissues and found that the enhancer exists in an array of three precisely positioned nucleos...

journal_title：Cell

authors： McPherson CE,Shim EY,Friedman DS,Zaret KS

更新日期：1993-10-22 00:00:00

abstract：:The tyrT locus of E. coli contains a 208 bp spacer region that separates two copies of sequence encoding tRNATyr1. The spacer includes a 120 bp sequence that is homologous to a sequence that is repeated three times in the distal portion of the tyrT locus. The tyrT locus possesses a graded set of transcription terminat...

journal_title：Cell

authors： Rossi J,Egan J,Hudson L,Landy A

更新日期：1981-11-01 00:00:00

abstract：:To determine the structural features responsible for the curvature of kinetoplast DNA, we studied 13 adenine tracts in Crithidia fasciculata kinetoplast DNA. The structures of the A tracts were analyzed by cutting the DNA with hydroxyl radical. Reactivity of hydroxyl radical toward the DNA backbone progressively decre...

journal_title：Cell

authors： Burkhoff AM,Tullius TD

更新日期：1987-03-27 00:00:00

abstract：:Certain mutant alleles at the low density lipoprotein (LDL) receptor locus produce receptors that bind LDL normally, but fail to cluster in coated pits and therefore cannot transport LDL into cells. We prepared genomic DNA libraries from cells of two individuals with this phenotype (internalization-defective familial ...

journal_title：Cell

authors： Lehrman MA,Goldstein JL,Brown MS,Russell DW,Schneider WJ

更新日期：1985-07-01 00:00:00

abstract：:A paradigm for control of insulin secretion is that glucose metabolism elevates cytoplasmic [ATP]/[ADP] in beta cells, closing K(ATP) channels and causing depolarization, Ca2+ entry, and insulin release. Decreased responsiveness of K(ATP) channels to elevated [ATP]/[ADP] should therefore lead to decreased insulin secr...

journal_title：Cell

authors： Koster JC,Marshall BA,Ensor N,Corbett JA,Nichols CG

更新日期：2000-03-17 00:00:00

abstract：:The fasciclin I, II, and III glycoproteins are expressed on different subsets of axon bundles (fascicles) in insect embryos and are thus candidates for surface recognition molecules involved in growth cone guidance. Here we present the sequence of grasshopper fasciclin I and the identification and sequence of the Dros...

journal_title：Cell

authors： Zinn K,McAllister L,Goodman CS

更新日期：1988-05-20 00:00:00

abstract：:In female mammals a "random choice" mechanism decides which of the two X chromosomes will be inactivated. It has been postulated that Xist is crucial for heterochromatinization and thus functions downstream of the choice mechanism. Here we report that females heterozygous for an internal deletion in the Xist gene, whi...

journal_title：Cell

authors： Marahrens Y,Loring J,Jaenisch R

更新日期：1998-03-06 00:00:00

abstract：:K-Ras is targeted to the plasma membrane by a C-terminal membrane anchor that comprises a farnesyl-cysteine-methyl-ester and a polybasic domain. We used quantitative spatial imaging and atomistic molecular dynamics simulations to examine molecular details of K-Ras plasma membrane binding. We found that the K-Ras ancho...

journal_title：Cell

authors： Zhou Y,Prakash P,Liang H,Cho KJ,Gorfe AA,Hancock JF

更新日期：2017-01-12 00:00:00

abstract：:Transposons evolve rapidly and can mobilize and trigger genetic instability. Piwi-interacting RNAs (piRNAs) silence these genome pathogens, but it is unclear how the piRNA pathway adapts to invasion of new transposons. In Drosophila, piRNAs are encoded by heterochromatic clusters and maternally deposited in the embryo...

journal_title：Cell

authors： Khurana JS,Wang J,Xu J,Koppetsch BS,Thomson TC,Nowosielska A,Li C,Zamore PD,Weng Z,Theurkauf WE

更新日期：2011-12-23 00:00:00

abstract：:Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced Plasmodium infection in vitro; however, the role of RBC dehydration in protection against malaria in vivo is unknown. Most cases of hereditary xer...

journal_title：Cell

authors： Ma S,Cahalan S,LaMonte G,Grubaugh ND,Zeng W,Murthy SE,Paytas E,Gamini R,Lukacs V,Whitwam T,Loud M,Lohia R,Berry L,Khan SM,Janse CJ,Bandell M,Schmedt C,Wengelnik K,Su AI,Honore E,Winzeler EA,Andersen KG,Patapou

更新日期：2018-04-05 00:00:00

abstract：:The cocrystal structure of human poly(A)-binding protein (PABP) has been determined at 2.6 A resolution. PABP recognizes the 3' mRNA poly(A) tail and plays critical roles in eukaryotic translation initiation and mRNA stabilization/degradation. The minimal PABP used in this study consists of the N-terminal two RRM-type...

journal_title：Cell

authors： Deo RC,Bonanno JB,Sonenberg N,Burley SK

更新日期：1999-09-17 00:00:00

abstract：:We have identified a novel octamer binding factor (Oct-3) in P19 embryonal carcinoma cells. Oct-3, which recognizes the typical octamer motif (ATTTGCAT) as well as the AT-rich sequence TTAAAATTCA, is present in P19 stem cells but disappears when the cells are induced to differentiate by retinoic acid (RA). Cloned cDNA...

journal_title：Cell

authors： Okamoto K,Okazawa H,Okuda A,Sakai M,Muramatsu M,Hamada H

更新日期：1990-02-09 00:00:00

abstract：:Insertion/deletion (IDL) mismatches in DNA are lesions consisting of extra bases on one strand. Here, the binding of p53 and its 14 kDa C-terminal domain to DNAs containing one or three 3-cytosine IDL mismatches was examined. Electron microscopy showed that both p53 forms bound predominantly as tetramers at the lesion...

journal_title：Cell

authors： Lee S,Elenbaas B,Levine A,Griffith J

更新日期：1995-06-30 00:00:00

abstract：:Symbiotic bacteria are important in animal hosts, but have been largely overlooked as they have proved difficult to culture in the laboratory. Approaches such as comparative genomics and real-time PCR have provided insights into the molecular mechanisms that underpin symbiont-host interactions. Studies on the heritabl...

journal_title：Cell

authors： Dale C,Moran NA

更新日期：2006-08-11 00:00:00

abstract：:Regulatory T cells (Tregs) play a pivotal role in the inhibition of anti-tumor immune responses. Understanding the mechanisms governing Treg homeostasis may therefore be important for development of effective tumor immunotherapy. We have recently demonstrated a key role for the canonical nuclear factor κB (NF-κB) subu...

journal_title：Cell

authors： Grinberg-Bleyer Y,Oh H,Desrichard A,Bhatt DM,Caron R,Chan TA,Schmid RM,Klein U,Hayden MS,Ghosh S

更新日期：2017-09-07 00:00:00

abstract：:The spindle pole body (SPB) is the microtubule organizing center (MTOC) in the yeast Saccharomyces that plays a pivotal role in such diverse processes as mitosis, budding, and mating. We have used cryoelectron microscopy and image processing to study the structure of isolated diploid SPBs. We show that SPBs are presen...

journal_title：Cell

authors： Bullitt E,Rout MP,Kilmartin JV,Akey CW

更新日期：1997-06-27 00:00:00

abstract：:Iron is ubiquitous in the environment and in biology. The study of iron biology focuses on physiology and homeostasis-understanding how cells and organisms regulate their iron content, how diverse tissues orchestrate iron allocation, and how dysregulated iron homeostasis leads to common hematological, metabolic, and n...

journal_title：Cell

authors： Hentze MW,Muckenthaler MU,Andrews NC

更新日期：2004-04-30 00:00:00

abstract：:In this study, we have located the sites of transcription initiation and termination on a cloned fragment of ribosomal DNA from X. laevis, and have sequenced the surrounding nucleotides. As reported previously (Reeder, Sollner-Webb and Wahn, 1977), about 25% of the 40S rRNA precursor molecules isolated from oocytes ha...

journal_title：Cell

authors： Sollner-Webb B,Reeder RH

更新日期：1979-10-01 00:00:00