TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family.

abstract：:The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a debilitating condition characterized by chronic tissue edema and impaired immunity. The recen...

journal_title：Cell

authors： Tammela T,Alitalo K

更新日期：2010-02-19 00:00:00

abstract：:Mycobacteria are unusual in encoding two GroEL paralogs, GroEL1 and GroEL2. GroEL2 is essential--presumably providing the housekeeping chaperone functions--while groEL1 is nonessential, contains the attB site for phage Bxb1 integration, and encodes a putative chaperone with unusual structural features. Inactivation of...

journal_title：Cell

authors： Ojha A,Anand M,Bhatt A,Kremer L,Jacobs WR Jr,Hatfull GF

更新日期：2005-12-02 00:00:00

abstract：:Conversion of glial cells into functional neurons represents a potential therapeutic approach for replenishing neuronal loss associated with neurodegenerative diseases and brain injury. Previous attempts in this area using expression of transcription factors were hindered by the low conversion efficiency and failure o...

journal_title：Cell

authors： Zhou H,Su J,Hu X,Zhou C,Li H,Chen Z,Xiao Q,Wang B,Wu W,Sun Y,Zhou Y,Tang C,Liu F,Wang L,Feng C,Liu M,Li S,Zhang Y,Xu H,Yao H,Shi L,Yang H

更新日期：2020-04-30 00:00:00

abstract：:A Drosophila gene with similarity to the mammalian Ras GTPase activating protein has been isolated in screens for mutations that affect eye development. Inactivation of the locus, Gap1, mimics constitutive activation of the Sevenless receptor tyrosine kinase and eliminates the need for a functional Sevenless protein i...

journal_title：Cell

authors： Gaul U,Mardon G,Rubin GM

更新日期：1992-03-20 00:00:00

abstract：:MicroRNAs are small endogenous noncoding RNAs involved in posttranscriptional gene regulation. During microRNA biogenesis, Drosha and Dicer process the primary transcript (pri-miRNA) through a precursor hairpin (pre-miRNA) to the mature miRNA. The miRNA is incorporated into the RNA-Induced Silencing Complex (RISC) wit...

journal_title：Cell

authors： Diederichs S,Haber DA

更新日期：2007-12-14 00:00:00

abstract：:We have investigated RNA recombination among poliovirus genomes by analyzing both intratypic and intertypic recombinant crosses involving the same defined genetic markers. Sequence analysis of the recombinant junctions of 13 nonsibling intertypic recombinants showed that intertypic RNA recombination is not site-specif...

journal_title：Cell

authors： Kirkegaard K,Baltimore D

更新日期：1986-11-07 00:00:00

abstract：:Targeted gene regulation on a genome-wide scale is a powerful strategy for interrogating, perturbing, and engineering cellular systems. Here, we develop a method for controlling gene expression based on Cas9, an RNA-guided DNA endonuclease from a type II CRISPR system. We show that a catalytically dead Cas9 lacking en...

journal_title：Cell

authors： Qi LS,Larson MH,Gilbert LA,Doudna JA,Weissman JS,Arkin AP,Lim WA

更新日期：2013-02-28 00:00:00

abstract：:The liver is capable of completely regenerating itself in response to injury and after partial hepatectomy. In liver of old animals, the proliferative response is dramatically reduced, the mechanism for which is unknown. The liver specific protein, C/EBPalpha, normally arrests proliferation of hepatocytes through inhi...

journal_title：Cell

authors： Iakova P,Awad SS,Timchenko NA

更新日期：2003-05-16 00:00:00

abstract：:Complex gene regulatory networks require transcription factors (TFs) to bind distinct DNA sequences. To understand how novel TF specificity evolves, we combined phylogenetic, biochemical, and biophysical approaches to interrogate how DNA recognition diversified in the steroid hormone receptor (SR) family. After duplic...

journal_title：Cell

authors： McKeown AN,Bridgham JT,Anderson DW,Murphy MN,Ortlund EA,Thornton JW

更新日期：2014-09-25 00:00:00

abstract：:The HIV-1 matrix (MA) protein contains two subcellular localization signals with opposing effects. A myristoylated N-terminus governs particle assembly at the plasma membrane, and a nucleophilic motif facilitates import of the viral preintegration complex into the nucleus of nondividing cells. Here, we show that myris...

journal_title：Cell

authors： Gallay P,Swingler S,Aiken C,Trono D

更新日期：1995-02-10 00:00:00

abstract：:The Hippo-signaling pathway is an important regulator of cellular proliferation and organ size. However, little is known about the role of this cascade in the control of cell fate. Employing a combination of lineage tracing, clonal analysis, and organoid culture approaches, we demonstrate that Hippo pathway activity i...

journal_title：Cell

authors： Yimlamai D,Christodoulou C,Galli GG,Yanger K,Pepe-Mooney B,Gurung B,Shrestha K,Cahan P,Stanger BZ,Camargo FD

更新日期：2014-06-05 00:00:00

abstract：:The fasciclin I, II, and III glycoproteins are expressed on different subsets of axon bundles (fascicles) in insect embryos and are thus candidates for surface recognition molecules involved in growth cone guidance. Here we present the sequence of grasshopper fasciclin I and the identification and sequence of the Dros...

journal_title：Cell

authors： Zinn K,McAllister L,Goodman CS

更新日期：1988-05-20 00:00:00

abstract：:Phosphorylation of histone H3 serine 10 correlates with chromosome condensation and is required for normal chromosome segregation in Tetrahymena. This phosphorylation is dependent upon activation of the NIMA kinase in Aspergillus nidulans. NIMA expression also induces Ser-10 phosphorylation inappropriately in S phase-...

journal_title：Cell

authors： De Souza CP,Osmani AH,Wu LP,Spotts JL,Osmani SA

更新日期：2000-08-04 00:00:00

abstract：:A unique DNA structural intermediate associated with termination of replication in Bacillus subtilis has been identified. This was achieved by probing for the Bam HI DNA fragment within which the terminus of the chromosome (terC) resides. The intermediate migrates more slowly than the bulk of digested chromosomal DNA ...

journal_title：Cell

authors： Weiss AS,Wake RG

更新日期：1984-12-01 00:00:00

abstract：:To determine whether phylogenetically conservative H-Y antigen plays any part in gonadal differentiation among the nonmammalian vertebrates, we studied expression and binding of H-Y in the frog, Xenopus laevis. Soluble H-Y obtained from mouse testis and soluble H-W from chicken ovary bound specifically to cells of the...

journal_title：Cell

authors： Wachtel SS,Bresler PA,Koide SS

更新日期：1980-07-01 00:00:00

abstract：:At anaphase onset, the protease separase triggers chromosome segregation by cleaving the chromosomal cohesin complex. Here, we show that cohesin destruction in metaphase is sufficient for segregation of much of the budding yeast genome, but not of the long arm of chromosome XII that contains the rDNA repeats. rDNA in ...

journal_title：Cell

authors： Sullivan M,Higuchi T,Katis VL,Uhlmann F

更新日期：2004-05-14 00:00:00

abstract：:p11, through unknown mechanisms, is required for behavioral and cellular responses to selective serotonin reuptake inhibitors (SSRIs). We show that SMARCA3, a chromatin-remodeling factor, is a target for the p11/annexin A2 heterotetrameric complex. Determination of the crystal structure indicates that SMARCA3 peptide ...

journal_title：Cell

authors： Oh YS,Gao P,Lee KW,Ceglia I,Seo JS,Zhang X,Ahn JH,Chait BT,Patel DJ,Kim Y,Greengard P

更新日期：2013-02-14 00:00:00

abstract：:All-trans retinoic acid (RA) has previously been shown to modulate the transcriptional properties of the retinoic acid receptor (RAR) and retinoid X receptor (RXR). The inability of all-trans RA to bind to RXR suggests that it may be metabolized to a more active high affinity ligand. We report here an experimental app...

journal_title：Cell

authors： Heyman RA,Mangelsdorf DJ,Dyck JA,Stein RB,Eichele G,Evans RM,Thaller C

更新日期：1992-01-24 00:00:00

abstract：:Actomyosin retrograde flow underlies the contraction essential for cell motility. Retrograde flow in both lamellipodia and lamella is required for membrane protrusion and for force generation by coupling to cell adhesion. We report that the Rac/Cdc42-binding kinase MRCK and myosin II-related MYO18A linked by the adapt...

journal_title：Cell

authors： Tan I,Yong J,Dong JM,Lim L,Leung T

更新日期：2008-10-03 00:00:00

abstract：:Bacteria can respond to adverse environmental conditions by drastically reducing or even ceasing metabolic activity. They must then determine that conditions have improved before exiting dormancy, and one indication of such a change is the growth of other bacteria in the local environment. Growing bacteria release mur...

journal_title：Cell

authors： Shah IM,Laaberki MH,Popham DL,Dworkin J

更新日期：2008-10-31 00:00:00

abstract：:Multidrug resistance in human cells results from increased expression of the mdr1 (P-glycoprotein) gene. Although the same gene is activated in cells selected with different drugs, multidrug-resistant cell lines can be preferentially resistant to their selecting agent. The mdr1 cDNA sequence from vinblastine-selected ...

journal_title：Cell

authors： Choi KH,Chen CJ,Kriegler M,Roninson IB

更新日期：1988-05-20 00:00:00

abstract：:We report that the 12,000 dalton domain of fibronectin that interacts with fibroblast cell surfaces also binds specifically to thrombin-inducible, saturable receptors on platelets. Furthermore, we have used chemical cross-linking and monoclonal antibodies to show that the 12,000 dalton domain of fibronectin interacts ...

journal_title：Cell

authors： Gardner JM,Hynes RO

更新日期：1985-09-01 00:00:00

abstract：:Cortical layer 1 (L1) interneurons have been proposed as a hub for attentional modulation of underlying cortex, but the transformations that this circuit implements are not known. We combined genetically targeted voltage imaging with optogenetic activation and silencing to study the mechanisms underlying sensory proce...

journal_title：Cell

authors： Fan LZ,Kheifets S,Böhm UL,Wu H,Piatkevich KD,Xie ME,Parot V,Ha Y,Evans KE,Boyden ES,Takesian AE,Cohen AE

更新日期：2020-02-06 00:00:00

abstract：:AU-rich elements (AREs), present in mRNA 3'-UTRs, are potent posttranscriptional regulatory signals that can rapidly effect changes in mRNA stability and translation, thereby dramatically altering gene expression with clinical and developmental consequences. In human cell lines, the TNFalpha ARE enhances translation r...

journal_title：Cell

authors： Vasudevan S,Steitz JA

更新日期：2007-03-23 00:00:00

abstract：:Synthesis of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], a signaling phospholipid, is primarily carried out by phosphatidylinositol 4-phosphate 5-kinase [PI(4)P5K], which has been reported to be regulated by RhoA and Rac1. Unexpectedly, we find that the GTPgammaS-dependent activator of PI(4)P5Kalpha is the smal...

journal_title：Cell

authors： Honda A,Nogami M,Yokozeki T,Yamazaki M,Nakamura H,Watanabe H,Kawamoto K,Nakayama K,Morris AJ,Frohman MA,Kanaho Y

更新日期：1999-11-24 00:00:00

abstract：:We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. ...

journal_title：Cell

authors： Leahy DJ,Aukhil I,Erickson HP

更新日期：1996-01-12 00:00:00

abstract：:Bacteria acquire memory of viral invaders by incorporating invasive DNA sequence elements into the host CRISPR locus, generating a new spacer within the CRISPR array. We report on the structures of Cas1-Cas2-dual-forked DNA complexes in an effort toward understanding how the protospacer is sampled prior to insertion i...

journal_title：Cell

authors： Wang J,Li J,Zhao H,Sheng G,Wang M,Yin M,Wang Y

更新日期：2015-11-05 00:00:00

abstract：:The thymus exports a selected subset of virgin T lymphocytes to the peripheral lymphoid organs. The mature phenotype of these thymus emigrants is similar to that of medullary thymocytes and has been cited as supporting a medullary rather than cortical exit site. Using the monoclonal antibody MEL-14, we identify a 1%-3...

journal_title：Cell

authors： Reichert RA,Gallatin WM,Butcher EC,Weissman IL

更新日期：1984-08-01 00:00:00

abstract：:NF-kappa B is a nuclear protein, found only in cells that transcribe immunoglobulin light chain genes, that interacts with a defined site in the kappa immunoglobulin enhancer. This protein can be induced in pre-B cells by stimulation with bacterial lipopolysaccharide (LPS). The induction involves a posttranslational a...

journal_title：Cell

authors： Sen R,Baltimore D

更新日期：1986-12-26 00:00:00

abstract：:The sigma factor sigma 70 of E. coli RNA polymerase acts not only in initiation, but also at an early stage of elongation to induce a transcription pause, and simultaneously to allow the phage lambda gene Q transcription antiterminator to act. We identify the signal in DNA that induces early pausing to be a version of...

journal_title：Cell

authors： Ring BZ,Yarnell WS,Roberts JW

更新日期：1996-08-09 00:00:00