Abstract：
:Two DNA sequences that reduce mitotic fidelity of chromosome transmission have been identified: MIF1 and MIF2. MIF1 is a unique sequence located on the right arm of chromosome XII that stimulates loss and recombination for both chromosomes V and VII when present in a high copy number plasmid. MIF1 is not essential for cell division but is necessary for the normal fidelity of chromosome transmission. MIF2 is a unique sequence located 15 cM distal to HIS6 on chromosome IX that induces a high frequency of chromosome VII loss and a lower frequency of chromosome V loss when present in high copy number; it has no effect on mitotic recombination. Disruption of the genomic MIF2 locus was lethal and cells lacking this function arrested division with a terminal phenotype characteristic of a block in DNA replication or nuclear division.
journal_name
Celljournal_title
Cellauthors
Meeks-Wagner D,Wood JS,Garvik B,Hartwell LHdoi
10.1016/0092-8674(86)90484-8subject
Has Abstractpub_date
1986-01-17 00:00:00pages
53-63issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(86)90484-8journal_volume
44pub_type
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