Molecular cloning and sequence analysis of a haploid expressed gene encoding t complex polypeptide 1.

abstract：:DNA double-strand breaks (DSBs) in B lymphocytes arise stochastically during replication or as a result of targeted DNA damage by activation-induced cytidine deaminase (AID). Here we identify recurrent, early replicating, and AID-independent DNA lesions, termed early replication fragile sites (ERFSs), by genome-wide l...

journal_title：Cell

authors： Barlow JH,Faryabi RB,Callén E,Wong N,Malhowski A,Chen HT,Gutierrez-Cruz G,Sun HW,McKinnon P,Wright G,Casellas R,Robbiani DF,Staudt L,Fernandez-Capetillo O,Nussenzweig A

更新日期：2013-01-31 00:00:00

abstract：:Rapid flow of information in the nervous system involves presynaptic vesicle recycling by clathrin-mediated endocytosis, an event triggered by the alpha-adaptin-containing AP2 complex. We identified a Drosophila alpha-adaptin expressed in the garland cells, imaginal discs, and the CNS. Here we show its role in presyna...

journal_title：Cell

authors： González-Gaitán M,Jäckle H

更新日期：1997-03-21 00:00:00

abstract：:The immunological synapse (IS) is a junction between the T cell and antigen-presenting cell and is composed of supramolecular activation clusters (SMACs). No studies have been published on naive T cell IS dynamics. Here, we find that IS formation during antigen recognition comprises cycles of stable IS formation and a...

journal_title：Cell

authors： Sims TN,Soos TJ,Xenias HS,Dubin-Thaler B,Hofman JM,Waite JC,Cameron TO,Thomas VK,Varma R,Wiggins CH,Sheetz MP,Littman DR,Dustin ML

更新日期：2007-05-18 00:00:00

abstract：:Upon exposure to 0.1 mM N-phosphonacetyl-L-aspartate (PALA), a transition state analog inhibitor of aspartate transcarbamylase, most cells of a simian virus 40 (SV40)-transformed Syrian hamster line are killed within a few days, but resistant mutants form spontaneously with frequency 2-5 X 10(-5) in a stochastic proce...

journal_title：Cell

authors： Kempe TD,Swyryd EA,Bruist M,Stark GR

更新日期：1976-12-01 00:00:00

abstract：:The elucidation of the genetic code remains among the most influential discoveries in biology. While innumerable studies have validated the general universality of the code and its value in predicting and analyzing protein coding sequences, established and emerging work has also suggested that full genome decryption m...

journal_title：Cell

authors： Brar GA

更新日期：2016-12-15 00:00:00

abstract：:Pathways that govern stem cell (SC) function are often subverted in cancer. Here, we report the isolation to near purity of human normal mammary SCs (hNMSCs), from cultured mammospheres, on the basis of their ability to retain the lipophilic dye PKH26 as a consequence of their quiescent nature. PKH26-positive cells po...

journal_title：Cell

authors： Pece S,Tosoni D,Confalonieri S,Mazzarol G,Vecchi M,Ronzoni S,Bernard L,Viale G,Pelicci PG,Di Fiore PP

更新日期：2010-01-08 00:00:00

abstract：:Defects in the gene encoding the endothelin-B receptor produce aganglionic megacolon and pigmentary disorders in mice and humans. We report that a targeted disruption of the mouse endothelin-3 ligand (EDN3) gene produces a similar recessive phenotype of megacolon and coat color spotting. A natural recessive mutation t...

journal_title：Cell

authors： Baynash AG,Hosoda K,Giaid A,Richardson JA,Emoto N,Hammer RE,Yanagisawa M

更新日期：1994-12-30 00:00:00

abstract：:Recent evidence suggests that a subset of cancer cells within some tumors, the so-called cancer stem cells, may drive the growth and metastasis of these tumors. Understanding the pathways that regulate proliferation, self-renewal, survival, and differentiation of malignant and normal stem cells may shed light on mecha...

journal_title：Cell

authors： Clarke MF,Fuller M

更新日期：2006-03-24 00:00:00

abstract：:Forskolin- and cholera toxin-activated adenylate cyclase activity increases between the morula and blastocyst stages of mouse preimplantation development, as assessed by the ability of these agents to increase embryonic cAMP levels. Development of activatable adenylate cyclase requires transcription but is independent...

journal_title：Cell

authors： Manejwala F,Kaji E,Schultz RM

更新日期：1986-07-04 00:00:00

abstract：:The Clock mutation lengthens periodicity and reduces amplitude of circadian rhythms in mice. The effects of Clock are cell intrinsic and can be observed at the level of single neurons in the suprachiasmatic nucleus. To address how cells of contrasting genotype functionally interact in vivo to control circadian behavio...

journal_title：Cell

authors： Low-Zeddies SS,Takahashi JS

更新日期：2001-04-06 00:00:00

abstract：:The major site of in vivo transcriptional initiation for both heavy and light strands of human mitochondrial DNA is the displacement-loop region. Transcripts synthesized in vitro by human mitochondrial RNA polymerase were mapped to the nucleotide level and have identical 5' end map positions to those reported for in v...

journal_title：Cell

authors： Chang DD,Clayton DA

更新日期：1984-03-01 00:00:00

abstract：:In the nucleus of eukaryotic cells, RNA decay in the 3'-5' direction is carried out by a complex of exonucleases called the exosome. Surprisingly, the purified exosome shows only weak activity in vitro. Two papers in this issue of Cell, by LaCava et al. (2005) and Wyers et al. (2005), and a third report by Vanacova et...

journal_title：Cell

authors： Jensen TH,Moore C

更新日期：2005-06-03 00:00:00

abstract：:The chromosomal distributions of five families of mouse r-protein genes (S16, L18, L19, L30 and L32/33) were studied by Southern blot analysis of DNa from a panel of mouse-hamster hybrid cells containing various complements of mouse chromosomes. Our results indicated that members of a particular family are often locat...

journal_title：Cell

authors： D'Eustachio P,Meyuhas O,Ruddle F,Perry RP

更新日期：1981-05-01 00:00:00

abstract：:The SIR2, SIR3, and SIR4 proteins are required for silencing of transcription at the silent mating type loci and at telomeres in yeast. Using protein affinity chromatography, we show that SIR2, SIR3, and two proteins of 69 and 110 kDa tightly associate with SIR4. Surprisingly, the 110 kDa SIR4-binding protein is ident...

journal_title：Cell

authors： Moazed D,Johnson D

更新日期：1996-08-23 00:00:00

abstract：:The mechanism by which MPF induces nuclear lamin disassembly and nuclear envelope breakdown during mitosis was studied in a frog egg extract in which the transition from interphase to mitosis can be induced by the addition of MPF. Bacterially expressed human nuclear lamin C, assembled in vitro into filaments, showed i...

journal_title：Cell

authors： Ward GE,Kirschner MW

更新日期：1990-05-18 00:00:00

abstract：:Chromatin assembly factor 1 (CAF-1) and Rtt106 participate in the deposition of newly synthesized histones onto replicating DNA to form nucleosomes. This process is critical for the maintenance of genome stability and inheritance of functionally specialized chromatin structures in proliferating cells. However, the mol...

journal_title：Cell

authors： Li Q,Zhou H,Wurtele H,Davies B,Horazdovsky B,Verreault A,Zhang Z

更新日期：2008-07-25 00:00:00

abstract：:Much of our understanding of chromosome segregation is based on cell culture systems. Here, we examine the importance of the tissue environment for chromosome segregation by comparing chromosome segregation fidelity across several primary cell types in native and nonnative contexts. We discover that epithelial cells h...

journal_title：Cell

authors： Knouse KA,Lopez KE,Bachofner M,Amon A

更新日期：2018-09-20 00:00:00

abstract：:The exchange of metabolites between the mitochondrial matrix and the cytosol depends on β-barrel channels in the outer membrane and α-helical carrier proteins in the inner membrane. The essential translocase of the inner membrane (TIM) chaperones escort these proteins through the intermembrane space, but the structura...

journal_title：Cell

authors： Weinhäupl K,Lindau C,Hessel A,Wang Y,Schütze C,Jores T,Melchionda L,Schönfisch B,Kalbacher H,Bersch B,Rapaport D,Brennich M,Lindorff-Larsen K,Wiedemann N,Schanda P

更新日期：2018-11-15 00:00:00

abstract：:We propose a mechanism for the priming of influenza viral RNA transcription by capped RNAs in which specific 5'-terminal fragments are cleaved from the capped RNAs by a virion-associated endonuclease. These fragments would serve as the actual primers for the initiation of transcription by the initial incorporation by ...

journal_title：Cell

authors： Plotch SJ,Bouloy M,Ulmanen I,Krug RM

更新日期：1981-03-01 00:00:00

abstract：:Developmental analysis of a newly isolated maternal effect grandchildless mutant, tudor (tud), in Drosophila melanogaster indicates that tud+ activity is required during oogenesis for the determination and/or formation of primordial germ cells (pole cells) and for normal embryonic abdominal segmentation. Regardless of...

journal_title：Cell

authors： Boswell RE,Mahowald AP

更新日期：1985-11-01 00:00:00

abstract：:The bHLH-ZIP protein Mad heterodimerizes with Max as a sequence-specific transcriptional repressor. Mad is rapidly induced upon differentiation, and the associated switch from Myc-Max to Mad-Max heterocomplexes seem to repress genes normally activated by Myc-Max. We have identified two related mammalian cDNAs that enc...

journal_title：Cell

authors： Ayer DE,Lawrence QA,Eisenman RN

更新日期：1995-03-10 00:00:00

abstract：:We have isolated and characterized a set of overlapping cDNA clones that encode the human centromere autoantigen centromere protein C (CENP-C). The identity of these clones has been established using several criteria. First, they were shown to encode a polypeptide that migrates at the expected position for CENP-C on S...

journal_title：Cell

authors： Saitoh H,Tomkiel J,Cooke CA,Ratrie H 3rd,Maurer M,Rothfield NF,Earnshaw WC

更新日期：1992-07-10 00:00:00

abstract：:Activation of plasma membrane calcium channels by depletion of endoplasmic reticulum (ER) calcium stores is important for calcium entry in many cell types. Park et al. (2009) now show that direct binding of the ER protein STIM to tetramers of the Orai1 calcium channel in the plasma membrane triggers opening of this ch...

journal_title：Cell

authors： Clapham DE

更新日期：2009-03-06 00:00:00

abstract：:We describe the comprehensive characterization of homeodomain DNA-binding specificities from a metazoan genome. The analysis of all 84 independent homeodomains from D. melanogaster reveals the breadth of DNA sequences that can be specified by this recognition motif. The majority of these factors can be organized into ...

journal_title：Cell

authors： Noyes MB,Christensen RG,Wakabayashi A,Stormo GD,Brodsky MH,Wolfe SA

更新日期：2008-06-27 00:00:00

abstract：:Females but not males of the low-lymphoma RF/J strain transmit a non-Mendelian factor which suppresses the development of lymphoma in F1 crosses with mice of the high-lymphoma AKR/J strain. Suppression of lymphoma was also evident in the first backcross generation to the parental AKR strain, but only when (RF female x...

journal_title：Cell

authors： Mayer A,Struuck FD,Duran-Reynals ML,Lilly F

更新日期：1980-02-01 00:00:00

abstract：:Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expressio...

journal_title：Cell

authors： Sanchez-Vega F,Mina M,Armenia J,Chatila WK,Luna A,La KC,Dimitriadoy S,Liu DL,Kantheti HS,Saghafinia S,Chakravarty D,Daian F,Gao Q,Bailey MH,Liang WW,Foltz SM,Shmulevich I,Ding L,Heins Z,Ochoa A,Gross B,Gao J,Z

更新日期：2018-04-05 00:00:00

abstract：:The chicken immunoglobulin light chain repertoire has been shown to be entirely derived from a single V lambda 1-J rearranged combination. The complete coding information of the lambda locus was determined: it comprises 25 V-hybridizing elements, all of which are pseudogenes, clustered in both orientations within 19 k...

journal_title：Cell

authors： Reynaud CA,Anquez V,Grimal H,Weill JC

更新日期：1987-02-13 00:00:00

abstract：:Biomechanical stress is a major stimulus for cardiac hypertrophy and the transition to heart failure. By generating mice that harbor a ventricular restricted knockout of the gp130 cytokine receptor via Cre-IoxP-mediated recombination, we demonstrate a critical role for a gp130-dependent myocyte survival pathway in the...

journal_title：Cell

authors： Hirota H,Chen J,Betz UA,Rajewsky K,Gu Y,Ross J Jr,Müller W,Chien KR

更新日期：1999-04-16 00:00:00

abstract：:Misfolded proteins of the ER are retrotranslocated to the cytosol, where they are polyubiquitinated, extracted from the membrane, and degraded by the proteasome. To investigate how the ER-associated Degradation (ERAD) machinery can accomplish retrotranslocation of a misfolded luminal protein domain across a lipid bila...

journal_title：Cell

authors： Baldridge RD,Rapoport TA

更新日期：2016-07-14 00:00:00

abstract：:Two precursor cell subpopulations have been isolated from the spleen cells of nonimmune mice. The major B cell subpopulation binds high levels of the J11D monoclonal antibody and, upon T cell-dependent antigenic stimulation, gives rise to primary antibody-forming cell clones but not secondary B cells. A minority of th...

journal_title：Cell

authors： Linton PJ L,Decker DJ,Klinman NR

更新日期：1989-12-22 00:00:00