CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate.

abstract：:The cpd mutation localized by T-DNA tagging on Arabidopsis chromosome 5-14.3 inhibits cell elongation controlled by the ecdysone-like brassinosteroid hormone brassinolide. The cpd mutant displays de-etiolation and derepression of light-induced genes in the dark, as well as dwarfism, male sterility, and activation of s...

journal_title：Cell

authors： Szekeres M,Németh K,Koncz-Kálmán Z,Mathur J,Kauschmann A,Altmann T,Rédei GP,Nagy F,Schell J,Koncz C

更新日期：1996-04-19 00:00:00

abstract：:In thymic epithelial cells, the protein Aire (autoimmune regulator) induces the ectopic expression of hundreds of peripheral tissue antigens, thus enlarging the repertoire of antigens available for the induction of central T cell tolerance. By analyzing Aire's interacting partners, Abramson et al. (2010) shed new ligh...

journal_title：Cell

authors： Kyewski B,Peterson P

更新日期：2010-01-08 00:00:00

abstract：:The intestinal microbiota produces tens of thousands of metabolites. Here, we used host sensing of small molecules by G-protein coupled receptors (GPCRs) as a lens to illuminate bioactive microbial metabolites that impact host physiology. We screened 144 human gut bacteria against the non-olfactory GPCRome and identif...

journal_title：Cell

authors： Chen H,Nwe PK,Yang Y,Rosen CE,Bielecka AA,Kuchroo M,Cline GW,Kruse AC,Ring AM,Crawford JM,Palm NW

更新日期：2019-05-16 00:00:00

abstract：:During aging, stromal functions are thought to be impaired, but little is known whether this stems from changes of fibroblasts. Using population- and single-cell transcriptomics, as well as long-term lineage tracing, we studied whether murine dermal fibroblasts are altered during physiological aging under different di...

journal_title：Cell

authors： Salzer MC,Lafzi A,Berenguer-Llergo A,Youssif C,Castellanos A,Solanas G,Peixoto FO,Stephan-Otto Attolini C,Prats N,Aguilera M,Martín-Caballero J,Heyn H,Benitah SA

更新日期：2018-11-29 00:00:00

abstract：:Chromosomal rearrangements, including translocations, require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are frequently involved in producing leukemias, lymphomas and sarcomas. Despite the importance of these events, current understanding of their gen...

journal_title：Cell

authors： Klein IA,Resch W,Jankovic M,Oliveira T,Yamane A,Nakahashi H,Di Virgilio M,Bothmer A,Nussenzweig A,Robbiani DF,Casellas R,Nussenzweig MC

更新日期：2011-09-30 00:00:00

abstract：:Bacteria have evolved many different means of generating movement. In this issue of Cell, Shaevitz et al. (2005) describe the swimming movement of a helical bacterium called Spiroplasma. They discover that Spiroplasma propels itself by generating two temporally distinct kinks that travel the length of the bacterium. T...

journal_title：Cell

authors： Wolgemuth CW,Charon NW

更新日期：2005-09-23 00:00:00

abstract：:Wnt signaling plays critical roles in development of various organs and pathogenesis of many diseases, and augmented Wnt signaling has recently been implicated in mammalian aging and aging-related phenotypes. We here report that complement C1q activates canonical Wnt signaling and promotes aging-associated decline in ...

journal_title：Cell

authors： Naito AT,Sumida T,Nomura S,Liu ML,Higo T,Nakagawa A,Okada K,Sakai T,Hashimoto A,Hara Y,Shimizu I,Zhu W,Toko H,Katada A,Akazawa H,Oka T,Lee JK,Minamino T,Nagai T,Walsh K,Kikuchi A,Matsumoto M,Botto M,Shiojima

更新日期：2012-06-08 00:00:00

abstract：:In S. cerevisiae, mitochondrial DNA (mtDNA) molecules, in spite of their high copy number, segregate as if there were a small number of heritable units. The rapid segregation of mitochondrial genomes can be analyzed using mtDNA deletion variants. These small, amplified genomes segregate preferentially from mixed zygot...

journal_title：Cell

authors： Lockshon D,Zweifel SG,Freeman-Cook LL,Lorimer HE,Brewer BJ,Fangman WL

更新日期：1995-06-16 00:00:00

abstract：:What happens to organelles during mitosis, and how they are apportioned to each of the daughter cells, is not completely clear. We have devised a procedure to address whether Golgi membranes fuse with the Endoplasmic Reticulum (ER) during mitosis via the detection of interactions between ER and Golgi proteins. This pr...

journal_title：Cell

authors： Pecot MY,Malhotra V

更新日期：2004-01-09 00:00:00

abstract：:Many proteins (intrinsically disordered proteins, IDPs) or regions of proteins (intrinsically disordered regions, IDRs) lack a well-defined 3D structure under physiological conditions. Albeit unfolded and highly dynamic, these proteins are not denatured; rather, intrinsic structural disorder is their native, functiona...

journal_title：Cell

authors： Guharoy M,Pauwels K,Tompa P

更新日期：2015-05-21 00:00:00

abstract：:The site on the HIV-1 gp120 glycoprotein that binds the CD4 receptor is recognized by broadly reactive antibodies, several of which neutralize over 90% of HIV-1 strains. To understand how antibodies achieve such neutralization, we isolated CD4-binding-site (CD4bs) antibodies and analyzed 16 co-crystal structures -8 de...

journal_title：Cell

authors： Zhou T,Lynch RM,Chen L,Acharya P,Wu X,Doria-Rose NA,Joyce MG,Lingwood D,Soto C,Bailer RT,Ernandes MJ,Kong R,Longo NS,Louder MK,McKee K,O'Dell S,Schmidt SD,Tran L,Yang Z,Druz A,Luongo TS,Moquin S,Srivatsan S,

更新日期：2015-06-04 00:00:00

abstract：:Proteolytic fragments of human plasma fibronectin were used to identify monoclonal antibodies reacting with the various domains of fibronectin. One of these antibodies, which reacts with cell-attachment-promoting fragments of fibronectin, inhibits attachment of cells to fibronectin-coated surfaces. A cell-attachment-p...

journal_title：Cell

authors： Pierschbacher MD,Hayman EG,Ruoslahti E

更新日期：1981-10-01 00:00:00

abstract：:N(6)-methyladenosine (m(6)A) is the most abundant internal modification in mammalian mRNA. This modification is reversible and non-stoichiometric and adds another layer to the dynamic control of mRNA metabolism. The stability of m(6)A-modified mRNA is regulated by an m(6)A reader protein, human YTHDF2, which recognize...

journal_title：Cell

authors： Wang X,Zhao BS,Roundtree IA,Lu Z,Han D,Ma H,Weng X,Chen K,Shi H,He C

更新日期：2015-06-04 00:00:00

abstract：:In female mammals a "random choice" mechanism decides which of the two X chromosomes will be inactivated. It has been postulated that Xist is crucial for heterochromatinization and thus functions downstream of the choice mechanism. Here we report that females heterozygous for an internal deletion in the Xist gene, whi...

journal_title：Cell

authors： Marahrens Y,Loring J,Jaenisch R

更新日期：1998-03-06 00:00:00

abstract：:SOCS1 is an SH2-containing protein that is primarily expressed in thymocytes in a cytokine- and T cell receptor-independent manner. SOCS1 deletion causes perinatal lethality with death by 2-3 weeks. During this period thymic changes include a loss of cellularity and a switch from predominantly CD4+ CD8+ to single posi...

journal_title：Cell

authors： Marine JC,Topham DJ,McKay C,Wang D,Parganas E,Stravopodis D,Yoshimura A,Ihle JN

更新日期：1999-09-03 00:00:00

abstract：:Bacterial flagella are driven by a rotary motor that utilizes the free energy stored in the electrochemical proton gradient across the cytoplasmic membrane to do mechanical work. The flux of protons coupled to motor rotation was measured in Streptococcus and found to be directly proportional to motor speed. This suppo...

journal_title：Cell

authors： Meister M,Lowe G,Berg HC

更新日期：1987-06-05 00:00:00

abstract：:In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein D614G rapidly became dominant around the world. Although clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are ...

journal_title：Cell

authors： Grubaugh ND,Hanage WP,Rasmussen AL

更新日期：2020-08-20 00:00:00

abstract：:In this study, we have located the sites of transcription initiation and termination on a cloned fragment of ribosomal DNA from X. laevis, and have sequenced the surrounding nucleotides. As reported previously (Reeder, Sollner-Webb and Wahn, 1977), about 25% of the 40S rRNA precursor molecules isolated from oocytes ha...

journal_title：Cell

authors： Sollner-Webb B,Reeder RH

更新日期：1979-10-01 00:00:00

abstract：:The mammalian circadian timing system is composed of a central pacemaker in the suprachiasmatic nucleus (SCN) of the brain and subsidiary oscillators in most peripheral cell types. While oscillators in SCN neurons are known to function in a self-sustained fashion, peripheral oscillators have been thought to damp rapid...

journal_title：Cell

authors： Nagoshi E,Saini C,Bauer C,Laroche T,Naef F,Schibler U

更新日期：2004-11-24 00:00:00

abstract：:Despite all modern advances in medicine, an effective drug treatment of obesity has not been found yet. Discovery of leptin two decades ago created hopes for treatment of obesity. However, development of leptin resistance has been a big obstacle, mitigating a leptin-centric treatment of obesity. Here, by using in sili...

journal_title：Cell

authors： Liu J,Lee J,Salazar Hernandez MA,Mazitschek R,Ozcan U

更新日期：2015-05-21 00:00:00

abstract：:In mouse intestinal tumors induced by the inhibition of APC, the restoration of APC function causes complete tumor regression with normal differentiation and return of stem cell function irrespective of whether tumors also carried mutations in Kras and p53. These findings by Dow et al. validate the Wnt pathway as an e...

journal_title：Cell

authors： Krimpenfort P,Berns A

更新日期：2015-06-18 00:00:00

abstract：:GroEL and GroES form a chaperonin nano-cage for proteins up to approximately 60 kDa to fold in isolation. Here we explored the structural features of the chaperonin cage critical for rapid folding of encapsulated substrates. Modulating the volume of the GroEL central cavity affected folding speed in accordance with co...

journal_title：Cell

authors： Tang YC,Chang HC,Roeben A,Wischnewski D,Wischnewski N,Kerner MJ,Hartl FU,Hayer-Hartl M

更新日期：2006-06-02 00:00:00

abstract：:Genetic screening identifies the atypical tetraspanin TM4SF1 as a strong mediator of metastatic reactivation of breast cancer. Intriguingly, TM4SF1 couples the collagen receptor tyrosine kinase DDR1 to the cortical adaptor syntenin 2 and, hence, to PKCα. The latter kinase phosphorylates and activates JAK2, leading to ...

journal_title：Cell

authors： Gao H,Chakraborty G,Zhang Z,Akalay I,Gadiya M,Gao Y,Sinha S,Hu J,Jiang C,Akram M,Brogi E,Leitinger B,Giancotti FG

更新日期：2016-06-30 00:00:00

abstract：:We have localized the regulatory sequence required for viral or poly(I)-poly(C) activation of human beta-interferon gene expression to a region located between -37 and -77 from the mRNA cap site. This sequence has the characteristics of an inducible enhancer element: it can act upstream or downstream of the beta-inter...

journal_title：Cell

authors： Goodbourn S,Zinn K,Maniatis T

更新日期：1985-06-01 00:00:00

abstract：:The rate of in vivo transcription from the E. coli tRNA and rRNA promoters depends on both cellular growth rate and aminoacid availability. To investigate the molecular mechanisms involved we determined the extent of interaction of RNA polymerase with the promoter of the tyrT stable RNA gene. We show that the enzyme c...

journal_title：Cell

authors： Travers AA,Lamond AI,Mace HA,Berman ML

更新日期：1983-11-01 00:00:00

abstract：:Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with over 370 structures in total bound to different ligands and the receptors in various conformational states. Structure-based drug design has been applied to an increasing number of GPCR targets over the past decade and now a few of t...

journal_title：Cell

authors： Congreve M,de Graaf C,Swain NA,Tate CG

更新日期：2020-04-02 00:00:00

abstract：:Synaptotagmin is an abundant synaptic vesicle-associated protein proposed to be involved in calcium-mediated neurotransmitter release. Our molecular and genetic results demonstrate that, although synaptotagmin is required for the proper function of the presynaptic nerve terminal in C. elegans, some neurotransmitter re...

journal_title：Cell

authors： Nonet ML,Grundahl K,Meyer BJ,Rand JB

更新日期：1993-07-02 00:00:00

abstract：:Lipid biology continues to emerge as an area of significant therapeutic interest, particularly as the result of an enhanced understanding of the wealth of signaling molecules with diverse physiological properties. This growth in knowledge is epitomized by lysophosphatidic acid (LPA), which functions through interactio...

journal_title：Cell

authors： Chrencik JE,Roth CB,Terakado M,Kurata H,Omi R,Kihara Y,Warshaviak D,Nakade S,Asmar-Rovira G,Mileni M,Mizuno H,Griffith MT,Rodgers C,Han GW,Velasquez J,Chun J,Stevens RC,Hanson MA

更新日期：2015-06-18 00:00:00

abstract：:Secretion of cytolytic granules content at the immunological synapse is a highly regulated process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of perforin containing lytic granules to the target cell interface, followed by their docking and fusion with the plasma membrane. Defective...

journal_title：Cell

authors： Feldmann J,Callebaut I,Raposo G,Certain S,Bacq D,Dumont C,Lambert N,Ouachée-Chardin M,Chedeville G,Tamary H,Minard-Colin V,Vilmer E,Blanche S,Le Deist F,Fischer A,de Saint Basile G

更新日期：2003-11-14 00:00:00

abstract：:X-ray studies have established that the structure of a right-handed, Watson-Crick double helix can change from place to place along its length as a function of base sequence. The base pairs transmit deformations out to the phosphate backbone, where they can then be recognized by proteins and other DNA-binding reagents...

journal_title：Cell

authors： Drew HR,Travers AA

更新日期：1984-06-01 00:00:00