Abstract：
:Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with over 370 structures in total bound to different ligands and the receptors in various conformational states. Structure-based drug design has been applied to an increasing number of GPCR targets over the past decade and now a few of these drug candidates have entered clinical trials. Given the length of time required for a drug to reach the market, there are no documented examples of licensed drugs being developed with the aid of a structure, but this is likely to change as current efforts come to fruition.
journal_name
Celljournal_title
Cellauthors
Congreve M,de Graaf C,Swain NA,Tate CGdoi
10.1016/j.cell.2020.03.003subject
Has Abstractpub_date
2020-04-02 00:00:00pages
81-91issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(20)30265-8journal_volume
181pub_type
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