Abstract:
:Cardiomyocytes, the cells of the heart muscle, lose nearly all of their proliferative capacity after birth, limiting the heart's ability to regenerate. Naqvi et al. now identify a transient burst of cardiomyocyte proliferation during preadolescence, driven by a thyroid hormone surge, with therapeutic implications for congenital and acquired heart diseases.
journal_name
Celljournal_title
Cellauthors
Palpant NJ,Murry CEdoi
10.1016/j.cell.2014.04.025subject
Has Abstractpub_date
2014-05-08 00:00:00pages
765-7issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(14)00543-1journal_volume
157pub_type
评论,杂志文章相关文献
CELL文献大全abstract::Trigger factor is a soluble, 63,000 dalton protein of E. coli that stabilizes proOmpA, the precursor form of a major outer-membrane protein, in a conformation competent for in vitro membrane assembly. There is approximately one trigger factor molecule bound to each 70S ribosome isolated from cell extracts in physiolog...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(88)90116-x
更新日期:1988-09-23 00:00:00
abstract::Previous experiments have shown that mRNA translation in frog oocytes can be inhibited by the injection of a complementary antisense RNA. Here we explore the use of antisense RNAs to study the functions of localized maternal mRNAs during postfertilization development. While developmental abnormalities were observed in...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90238-8
更新日期:1987-02-27 00:00:00
abstract::Following TGFbeta receptor-mediated phosphorylation and association with Smad4, Smad2 moves into the nucleus, binds to target promoters in association with DNA-binding cofactors, and recruits coactivators such as p300/CBP to activate transcription. We identified the homeodomain protein TGIF as a Smad2-binding protein ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80712-6
更新日期:1999-04-02 00:00:00
abstract::In a recent paper in Nature, show that the immunoreceptor PD-1 is upregulated by "exhausted" T cells during the chronic phase of viral infection in mice. Remarkably, blocking the interaction between PD-1 and its ligand, PD-L1, reactivates these T cells and reduces viral load. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2006.01.022
更新日期:2006-02-10 00:00:00
abstract::Congenital scoliosis, a lateral curvature of the spine caused by vertebral defects, occurs in approximately 1 in 1,000 live births. Here we demonstrate that haploinsufficiency of Notch signaling pathway genes in humans can cause this congenital abnormality. We also show that in a mouse model, the combination of this g...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.02.054
更新日期:2012-04-13 00:00:00
abstract::Dopamine neurons promote learning by processing recent changes in reward values, such that reward may be maximized. However, such a flexible signal is not suitable for habitual behaviors that are sustained regardless of recent changes in reward outcome. We discovered a type of dopamine neuron in the monkey substantia ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.10.063
更新日期:2015-11-19 00:00:00
abstract::The cpd mutation localized by T-DNA tagging on Arabidopsis chromosome 5-14.3 inhibits cell elongation controlled by the ecdysone-like brassinosteroid hormone brassinolide. The cpd mutant displays de-etiolation and derepression of light-induced genes in the dark, as well as dwarfism, male sterility, and activation of s...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81094-6
更新日期:1996-04-19 00:00:00
abstract::Fluorescent proteins are commonly used to label cells across organisms, but the unmodified forms cannot control biological activities. Using GFP-binding proteins derived from Camelid antibodies, we co-opted GFP as a scaffold for inducing formation of biologically active complexes, developing a library of hybrid transc...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.07.021
更新日期:2013-08-15 00:00:00
abstract::Receptor dimerization is ubiquitous to the action of all receptor tyrosine kinases, and in the case of dimeric ligands, such as the stem cell factor (SCF), it was attributed to ligand bivalency. However, by using a dimerization-inhibitory monoclonal antibody to the SCF receptor, we confined a putative dimerization sit...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90455-7
更新日期:1995-01-13 00:00:00
abstract::The crystal structure of the β2-adrenergic receptor (β2AR) bound to the G protein adenylyl cyclase stimulatory G protein (Gs) captured the complex in a nucleotide-free state (β2AR-Gsempty). Unfortunately, the β2AR-Gsempty complex does not provide a clear explanation for G protein coupling specificity. Evidence from se...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.04.021
更新日期:2019-05-16 00:00:00
abstract::TGF-beta signaling controls a plethora of cellular responses and figures prominently in animal development. Recent cellular, biochemical, and structural studies have revealed significant insight into the mechanisms of the activation of TGF-beta receptors through ligand binding, the activation of Smad proteins through ...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/s0092-8674(03)00432-x
更新日期:2003-06-13 00:00:00
abstract::The non-receptor protein tyrosine phosphatase (PTP) SHP2, encoded by PTPN11, plays an essential role in RAS-mitogen-activated protein kinase (MAPK) signaling during normal development. It has been perplexing as to why both enzymatically activating and inactivating mutations in PTPN11 result in human developmental diso...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.09.002
更新日期:2020-10-15 00:00:00
abstract::The rps12 gene codes for chloroplast ribosomal protein S12. In the tobacco chloroplast genome (156 kbp circular DNA), exons II and III of this gene are separated by an intron of 536 bases and are present in two copies in the inverted repeat region, while exon I is located in the large single copy region at a distance ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90361-8
更新日期:1987-01-16 00:00:00
abstract::The mammalian alpha- and beta--globin genes are thought to have evolved from a common ancestral sequence by a duplication event that occurred over 500 million years ago. We have now determined the entire nucleotide sequence of a cloned mouse alpha--globin gene, including regions that flank and interrupt the coding seq...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(79)90139-9
更新日期:1979-11-01 00:00:00
abstract::It is increasingly appreciated that oncogenic transformation alters cellular metabolism to facilitate cell proliferation, but less is known about the metabolic changes that promote cancer cell aggressiveness. Here, we analyzed metabolic gene expression in cancer cell lines and found that a set of high-grade carcinoma ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.07.032
更新日期:2014-08-28 00:00:00
abstract::Several metabolic alterations accumulate over time along with a reduction in biological fitness, suggesting the existence of a "metabolic clock" that controls aging. Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. Each of the...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2016.07.031
更新日期:2016-08-11 00:00:00
abstract::Multisite hyperphosphorylation of tau has been implicated in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). However, the phosphorylation events critical for tau toxicity and mechanisms regulating these events are largely unknown. Here we show that Drosophila PAR-1 kinase initiates t...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(04)00170-9
更新日期:2004-03-05 00:00:00
abstract::Meiotic recombination occurs preferentially between homologous nonsister chromatids rather than between sisters, opposite to the bias of mitotic recombinational repair. We have examined formation of joint molecule recombination intermediates (JMs) between homologs and between sisters in yeast strains lacking the meiot...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80378-5
更新日期:1997-09-19 00:00:00
abstract::While the tumor suppressor functions of p53 have long been recognized, the contribution of p53 to numerous other aspects of disease and normal life is only now being appreciated. This burgeoning range of responses to p53 is reflected by an increasing variety of mechanisms through which p53 can function, although the a...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2009.04.037
更新日期:2009-05-01 00:00:00
abstract::O(2) is the ultimate electron acceptor for mitochondrial respiration, a process catalyzed by cytochrome c oxidase (COX). In yeast, COX subunit composition is regulated by COX5a and COX5b gene transcription in response to high and low O(2), respectively. Here we demonstrate that in mammalian cells, expression of the CO...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.01.047
更新日期:2007-04-06 00:00:00
abstract::Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expressio...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.03.035
更新日期:2018-04-05 00:00:00
abstract::We have reconstituted the fusion and assembly of vesiculated Golgi membranes (VGMs) into functionally active stacks of cisternae. A kinetic analysis of this assembly process revealed that highly dispersed VGMs of 60-90 nm diameter first fuse to form larger vesicles of 200-300 nm diameter that are clustered together. T...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90269-4
更新日期:1995-09-22 00:00:00
abstract::All recombination models postulate one or more recombination intermediates that are joint molecules containing two homologous parental molecules. A spike of branched DNA molecules not seen in DNA from mitotic cells was found in the two-dimensional gel analysis of meiotic DNA from S. cerevisiae. The mass of molecules i...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(94)90173-2
更新日期:1994-01-14 00:00:00
abstract::The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a clas...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2012.07.020
更新日期:2012-08-17 00:00:00
abstract::The small molecular weight RNAs of the HeLa cell have been located in specific subcellular fractions. SnA is located in the nucleolus and is partially bonded to nucleolar 28S RNA. SnD, the most abundant of the small nuclear RNAs, is partially released from the nucleus when the nuclear preparation is briefly warmed. Sn...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(76)90181-1
更新日期:1976-05-01 00:00:00
abstract::The distribution of sense and antisense strand DNA mutations on transcribed duplex DNA contributes to the development of immune and neural systems along with the progression of cancer. Because developmentally matured B cells undergo biologically programmed strand-specific DNA mutagenesis at focal DNA/RNA hybrid struct...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.03.043
更新日期:2017-04-20 00:00:00
abstract::Meiotic cohesin serves in sister chromatid linkage and DNA repair until its subunit Rec8 is cleaved by separase. Separase is activated when its inhibitor, securin, is polyubiquitinated by the Cdc20 regulated anaphase-promoting complex (APC(Cdc20)) and consequently degraded. Differently regulated APCs (APC(Cdh1), APC(A...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2005.01.017
更新日期:2005-03-25 00:00:00
abstract::Our previous deletion experiments have shown that a short region of yeast nuclear gene introns containing the conserved sequence 5'-TACTAACA-3' is essential for splicing. In this report we show that the chemically synthesized decanucleotide 5'-TGTACTAACA-3', when introduced into a hybrid gene forming unspliceable RNA ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90344-1
更新日期:1984-03-01 00:00:00
abstract::Sirtuins are thought to form crucial links between energy levels and cellular metabolism. Libert et al. now provide evidence that SIRT1 activity in the brain modifies mammalian emotional behavior via monoamine signaling and that changes in this pathway might contribute to human affective disorders. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2011.11.052
更新日期:2011-12-23 00:00:00
abstract::Individual olfactory sensory neurons express only a single odorant receptor from a large family of genes, and this singularity is an essential feature in models of olfactory perception. We have devised a genetic strategy to examine the stability of receptor choice. We observe that immature olfactory sensory neurons th...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2004.05.015
更新日期:2004-06-11 00:00:00