Abstract:
:The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.
journal_name
Celljournal_title
Cellauthors
Codelia VA,Irvine KDdoi
10.1016/j.cell.2012.07.020subject
Has Abstractpub_date
2012-08-17 00:00:00pages
669-70issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(12)00888-4journal_volume
150pub_type
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