Abstract:
:Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (CLR + RAMP1) offer considerable improvements over existing drugs in migraine prophylaxis and are the first designed to act on the trigeminal pain system. Erenumab is approved by the FDA and EMA and has reached the market since May 2018. Two antibodies, fremanezumab and galcanezumab, directed towards the CGRP ligand, were approved by the FDA in September 2018. To view this Bench to Bedside, open or download the PDF.
journal_name
Celljournal_title
Cellauthors
Edvinsson Ldoi
10.1016/j.cell.2018.11.049subject
Has Abstractpub_date
2018-12-13 00:00:00pages
1719issue
7eissn
0092-8674issn
1097-4172pii
S0092-8674(18)31574-5journal_volume
175pub_type
杂志文章,评审相关文献
CELL文献大全abstract::Determining which neurite of a differentiating neuron is to become the axon is a crucial step in neuronal morphogenesis. Two groups (Barnes et al., 2007; Shelly et al., 2007) now report that axon specification in vivo is mediated by extracellular signals acting through the serine/threonine kinase LKB1. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2007.04.021
更新日期:2007-05-04 00:00:00
abstract::We have localized the regulatory sequence required for viral or poly(I)-poly(C) activation of human beta-interferon gene expression to a region located between -37 and -77 from the mRNA cap site. This sequence has the characteristics of an inducible enhancer element: it can act upstream or downstream of the beta-inter...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(85)80024-6
更新日期:1985-06-01 00:00:00
abstract::Use-dependent synapse remodeling is thought to provide a cellular mechanism for encoding durable memories, yet whether activity triggers an actual structural change has remained controversial. We use photoconductive stimulation to demonstrate activity-dependent morphological synaptic plasticity by video imaging of GFP...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)00579-7
更新日期:2001-11-30 00:00:00
abstract::Phosphodiesterases (PDEs) regulate the local concentration of 3',5' cyclic adenosine monophosphate (cAMP) within cells. cAMP activates the cAMP-dependent protein kinase (PKA). In patients, PDE inhibitors have been linked to heart failure and cardiac arrhythmias, although the mechanisms are not understood. We show that...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2005.07.030
更新日期:2005-10-07 00:00:00
abstract::During C. elegans embryogenesis an 8-cell stage blastomere, called MS, undergoes a reproducible cleavage pattern, producing pharyngeal cells, body wall muscles, and cell deaths. We show here that maternal-effect mutations in the pie-1 and mex-1 genes cause additional 8-cell stage blastomeres to adopt a fate very simil...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90542-k
更新日期:1992-07-10 00:00:00
abstract::Excessive accumulation of neurofilaments in the cell bodies and proximal axons of motor neurons is a major pathological hallmark during the early stages of many human motor neuron diseases. To test directly the consequence of overexpression of the major neurofilament subunit NF-L, we produced transgenic mice that accu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(93)90157-l
更新日期:1993-04-09 00:00:00
abstract::The Bcl-2 family member Bax translocates from the cytosol to mitochondria, where it oligomerizes and permeabilizes the mitochondrial outer membrane to promote apoptosis. Bax activity is counteracted by prosurvival Bcl-2 proteins, but how they inhibit Bax remains controversial because they neither colocalize nor form s...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2011.02.034
更新日期:2011-04-01 00:00:00
abstract::We report the identification and characterization of a class of IS10 transposase mutants that carry out only some of the steps required for transposition. These mutants were identified among transposition-defective mutants as a specific subclass that retains the wild-type ability to induce SOS functions in the presenc...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(89)90299-7
更新日期:1989-10-20 00:00:00
abstract::Sirtuins are thought to form crucial links between energy levels and cellular metabolism. Libert et al. now provide evidence that SIRT1 activity in the brain modifies mammalian emotional behavior via monoamine signaling and that changes in this pathway might contribute to human affective disorders. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2011.11.052
更新日期:2011-12-23 00:00:00
abstract::Autosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telomerase. To examine the dosage effect of telomerase, we generated a line of mTR+/- mice on the CAST/EiJ background, which has short telomeres. Interbreeding of heterozygotes resulted in progressive telomere shortening, indicating...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2005.11.020
更新日期:2005-12-16 00:00:00
abstract::A major challenge to understanding how cells work together in the central nervous system (CNS) is the heterogeneous cellular composition of the brain. In this issue, Heiman et al. (2008) and Doyle et al. (2008) introduce a new strategy (TRAP) that enables the profiling of translated mRNAs in specific CNS cell populati...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2008.10.031
更新日期:2008-11-14 00:00:00
abstract::Mitochondrial Ca(2+) (Ca(2+)(m)) uptake is mediated by an inner membrane Ca(2+) channel called the uniporter. Ca(2+) uptake is driven by the considerable voltage present across the inner membrane (ΔΨ(m)) generated by proton pumping by the respiratory chain. Mitochondrial matrix Ca(2+) concentration is maintained five ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.10.011
更新日期:2012-10-26 00:00:00
abstract::We report the discovery of a short-lived chaperone that is required for the correct maturation of the eukaryotic 20S proteasome and is destroyed at a specific stage of the assembly process. The S. cerevisiae Ump1p protein is a component of proteasome precursor complexes containing unprocessed beta subunits but is not ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80942-3
更新日期:1998-02-20 00:00:00
abstract::Chemical modifications of histones and DNA, such as histone methylation, histone acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of the enzymes that add or remove such chemical modifications are known, or might be suspected, to be sensitive to changes in intracellular metaboli...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2013.03.004
更新日期:2013-03-28 00:00:00
abstract::Germinal centers develop in peripheral lymphatic tissue during the primary immune response and may play a crucial role in affinity maturation. We have compared the diversification of the antigen-specific repertoire of B cells, both from within and from outside the germinal centers, during the murine response to 2-phen...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90289-b
更新日期:1991-12-20 00:00:00
abstract::32P-labeled cowpea mosaic virus (CPMV) RNAs were analyzed for their 5' termini by three different fingerprinting standard procedures. These analyses showed unequivocally that CPMV RNAs lack a structure like m7GpppN ... at their 5' termini. In addition, neither mono-, di- or triphosphorylated [(p)(p)pN ....] termini we...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(77)90318-x
更新日期:1977-05-01 00:00:00
abstract::The expression of MHC class II genes is tightly regulated. One form of congenital severe combined immunodeficiency (SCID) is characterized by a regulatory defect that precludes expression of HLA class II genes. B lymphocyte cell lines from such SCID patients provide a tool for identifying putative regulatory proteins ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(88)90389-3
更新日期:1988-06-17 00:00:00
abstract::X-linked recessive chondrodysplasia punctata (CDPX) is a congenital defect of bone and cartilage development characterized by aberrant bone mineralization, severe underdevelopment of nasal cartilage, and distal phalangeal hypoplasia. A virtually identical phenotype is observed in the warfarin embryopathy, which is due...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90367-4
更新日期:1995-04-07 00:00:00
abstract::Although specific microRNAs (miRNAs) can be upregulated in cancer, global miRNA downregulation is a common trait of human malignancies. The mechanisms of this phenomenon and the advantages it affords remain poorly understood. Here we identify a microRNA family, miR-103/107, that attenuates miRNA biosynthesis by target...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2010.05.017
更新日期:2010-06-25 00:00:00
abstract::I have identified an activity in crude HeLa cell extracts that satisfies the requirements for a human telomere terminal transferase or telomerase. It catalyzes the addition of a 6 nucleotide repeating pattern to oligonucleotide primers containing human or nonhuman telomeric repeat sequences. Direct sequence analyses o...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(89)90035-4
更新日期:1989-11-03 00:00:00
abstract::We have performed in vitro kinetic analyses of transcription from the 5S gene promoter in order to resolve the rate-limiting events which lead to accurate transcription of the 5S RNA gene. We demonstrate that a rate-limiting intermediate can be formed during an extended incubation prior to initiation of transcription....
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(85)90315-0
更新日期:1985-01-01 00:00:00
abstract::Inconsistent with the view that hair follicle stem cells reside in the matrix area of the hair bulb, we found that label-retaining cells exist exclusively in the bulge area of the mouse hair follicle. The bulge consists of a subpopulation of outer root sheath cells located in the midportion of the follicle at the arre...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90696-c
更新日期:1990-06-29 00:00:00
abstract::DNA interstrand crosslinks (ICLs) are toxic DNA lesions whose repair occurs in the S phase of metazoans via an unknown mechanism. Here, we describe a cell-free system based on Xenopus egg extracts that supports ICL repair. During DNA replication of a plasmid containing a site-specific ICL, two replication forks conver...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2008.08.030
更新日期:2008-09-19 00:00:00
abstract::RECQL5 is the sole member of the RECQ family of helicases associated with RNA polymerase II (RNAPII). We now show that RECQL5 is a general elongation factor that is important for preserving genome stability during transcription. Depletion or overexpression of RECQL5 results in corresponding shifts in the genome-wide R...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.03.048
更新日期:2014-05-22 00:00:00
abstract::At the final step of homologous recombination, Holliday junction-containing joint molecules (JMs) are resolved to form crossover or noncrossover products. The enzymes responsible for JM resolution in vivo remain uncertain, but three distinct endonucleases capable of resolving JMs in vitro have been identified: Mus81-M...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.03.023
更新日期:2012-04-13 00:00:00
abstract::Gastrointestinal enterochromaffin cells regulate bone and gut homeostasis via serotonin (5-hydroxytryptamine [5-HT]) production. A recent report suggested that gut microbes regulate 5-HT levels; however, the precise underlying molecular mechanisms are unexplored. Here, we reveal that the cation channel Piezo1 in the g...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.06.022
更新日期:2020-08-06 00:00:00
abstract::Genetic analyses in Drosophila have demonstrated that the multipass membrane protein Smoothened (Smo) is essential for all Hedgehog signaling. We show that Smo acts epistatic to Ptc1 to mediate Shh and Ihh signaling in the early mouse embryo. Smo and Shh/Ihh compound mutants have identical phenotypes: embryos fail to ...
journal_title:Cell
pub_type: 杂志文章
doi:
更新日期:2001-06-15 00:00:00
abstract::Mitochondrial DNA is compacted into nucleoprotein complexes denoted mitochondrial nucleoids, the focus of this SnapShot. ...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2017.12.039
更新日期:2018-01-11 00:00:00
abstract::Exchange factors for ARF GTPases (ARF-GEFs) regulate vesicle trafficking in a variety of organisms. The Arabidopsis protein GNOM is a brefeldin A (BFA) sensitive ARF-GEF that is required for the proper polar localization of PIN1, a candidate transporter of the plant hormone auxin. Mutations in GNOM lead to development...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(03)00003-5
更新日期:2003-01-24 00:00:00
abstract::Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable methods to identify and interrogate pathways involved in pancreatic tumorigenesis are urgently needed. We established organoid models from normal and neoplastic murine and human pancreas tiss...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.12.021
更新日期:2015-01-15 00:00:00