CGRP Antibodies as Prophylaxis in Migraine.

Abstract:

:Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (CLR + RAMP1) offer considerable improvements over existing drugs in migraine prophylaxis and are the first designed to act on the trigeminal pain system. Erenumab is approved by the FDA and EMA and has reached the market since May 2018. Two antibodies, fremanezumab and galcanezumab, directed towards the CGRP ligand, were approved by the FDA in September 2018. To view this Bench to Bedside, open or download the PDF.

journal_name

Cell

journal_title

Cell

authors

Edvinsson L

doi

10.1016/j.cell.2018.11.049

subject

Has Abstract

pub_date

2018-12-13 00:00:00

pages

1719

issue

7

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(18)31574-5

journal_volume

175

pub_type

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