Abstract：
:Compared to sperm nuclei, nuclei from adult somatic cells replicate inefficiently in frog egg extract. In this issue of Cell, Lemaitre et al. (2005) show that pre-exposure of erythrocyte nuclei to a mitotic extract removes this difference, reorganizes the chromatin into shorter loops, and allows replication at much shorter intervals along the DNA. Remarkably, these observations also explain an old mystery of why serial nuclear transplantation was so successful for cloning frogs.
journal_name
Celljournal_title
Cellauthors
Laskey Rdoi
10.1016/j.cell.2005.11.008subject
Has Abstractpub_date
2005-12-02 00:00:00pages
760-2issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(05)01174-8journal_volume
123pub_type
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