Mechanobiology of Protein Droplets: Force Arises from Disorder.

Abstract:

:The use of optogenetic approaches has revealed new roles for intracellular protein condensates described in two papers in this issue of Cell (Bracha et. al., 2018; Shin et al., 2018). These results show that growing condensates are able to exert mechanical forces resulting in chromatin rearrangement, establishing a new role for liquid-liquid phase separation in the mechanobiology of the cell.

journal_name

Cell

journal_title

Cell

authors

Welsh TJ,Shen Y,Levin A,Knowles TPJ

doi

10.1016/j.cell.2018.11.020

subject

Has Abstract

pub_date

2018-11-29 00:00:00

pages

1457-1459

issue

6

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(18)31512-5

journal_volume

175

pub_type

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