Abstract：
:Meiotic recombination occurs preferentially between homologous nonsister chromatids rather than between sisters, opposite to the bias of mitotic recombinational repair. We have examined formation of joint molecule recombination intermediates (JMs) between homologs and between sisters in yeast strains lacking the meiotic chromosomal protein Red1, the meiotic recA homolog Dmc1, and/or mitotic recA homolog(s), Rad51, Rad55, and Rad57. Mutant phenotypes imply that most meiotic recombination occurs via an interhomolog-only pathway along which interhomolog bias is established early, prior to or during double strand break (DSB) formation, and then enforced, just at the time when DSBs initiate JM formation. A parallel, less differentiated pathway yields intersister and, probably, a few interhomolog events. Coordinate action of mitotic recA homologs as one functional unit, two functions of RED1, and an interhomolog interaction function of DMC1 are also revealed.
journal_name
Celljournal_title
Cellauthors
Schwacha A,Kleckner Ndoi
10.1016/s0092-8674(00)80378-5subject
Has Abstractpub_date
1997-09-19 00:00:00pages
1123-35issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(00)80378-5journal_volume
90pub_type
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