Abstract：
:Recently, a Drosophila gene has been identified, extradenticle, whose product modulates the morphological consequences of homeotic selector genes. We show here that extradenticle protein raises the DNA binding specificity of Ultrabithorax and abdominal-A but not that of Abdominal-B. We further show that extradenticle modulates the DNA binding activity of engrailed to a different target site. While a region N-terminal of the extradenticle homeodomain is required for Ultrabithorax and abdominal-A cooperativity, engrailed requires a domain C-terminal of the extradenticle homeobox. These studies show directly how the DNA binding specificity of selector gene products can be raised by extradenticle and provides a mechanism, cooperative DNA binding, that allows selector gene products to achieve some of their biological specificity.
journal_name
Celljournal_title
Cellauthors
van Dijk MA,Murre Cdoi
10.1016/0092-8674(94)90526-6subject
Has Abstractpub_date
1994-08-26 00:00:00pages
617-24issue
4eissn
0092-8674issn
1097-4172pii
0092-8674(94)90526-6journal_volume
78pub_type
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