Neural induction is mediated by cross-talk between the protein kinase C and cyclic AMP pathways.

abstract：:Complex gene regulatory networks require transcription factors (TFs) to bind distinct DNA sequences. To understand how novel TF specificity evolves, we combined phylogenetic, biochemical, and biophysical approaches to interrogate how DNA recognition diversified in the steroid hormone receptor (SR) family. After duplic...

journal_title：Cell

authors： McKeown AN,Bridgham JT,Anderson DW,Murphy MN,Ortlund EA,Thornton JW

更新日期：2014-09-25 00:00:00

abstract：:The small molecular weight RNAs of the HeLa cell have been located in specific subcellular fractions. SnA is located in the nucleolus and is partially bonded to nucleolar 28S RNA. SnD, the most abundant of the small nuclear RNAs, is partially released from the nucleus when the nuclear preparation is briefly warmed. Sn...

journal_title：Cell

authors： Zieve G,Penman S

更新日期：1976-05-01 00:00:00

abstract：:The elucidation of the genetic code remains among the most influential discoveries in biology. While innumerable studies have validated the general universality of the code and its value in predicting and analyzing protein coding sequences, established and emerging work has also suggested that full genome decryption m...

journal_title：Cell

authors： Brar GA

更新日期：2016-12-15 00:00:00

abstract：:Certain tRNAs in S. cerevisiae (tRNATyr and tRNAPhe) arise via precursor molecules which are mature at the 5' and 3' termini but contain intervening sequences adjacent to the anticodon (Knapp et al., 1978; O'Farrell et al., 1978). In addition to these molecules, precursors to several other tRNAs accumulate in a temper...

journal_title：Cell

authors： Etcheverry T,Colby D,Guthrie C

更新日期：1979-09-01 00:00:00

abstract：:Pathogenic simian immunodeficiency virus (SIV) infection is associated with enteropathy, which likely contributes to AIDS progression. To identify candidate etiologies for AIDS enteropathy, we used next-generation sequencing to define the enteric virome during SIV infection in nonhuman primates. Pathogenic, but not no...

journal_title：Cell

authors： Handley SA,Thackray LB,Zhao G,Presti R,Miller AD,Droit L,Abbink P,Maxfield LF,Kambal A,Duan E,Stanley K,Kramer J,Macri SC,Permar SR,Schmitz JE,Mansfield K,Brenchley JM,Veazey RS,Stappenbeck TS,Wang D,Barouch DH,

更新日期：2012-10-12 00:00:00

abstract：:Mutations in gurken and torpedo cause a ventralization in the follicle cell epithelium during Drosophila oogenesis and in the pattern of the embryo that develops in the resultant egg. Both genes lie midway in an epistatic series between fs(1)K10 and dorsal; the mutations block the dorsalization normally observed in K1...

journal_title：Cell

authors： Schüpbach T

更新日期：1987-06-05 00:00:00

abstract：:The mitochondrial unfolded protein response (UPRmt) can be triggered in a cell-non-autonomous fashion across multiple tissues in response to mitochondrial dysfunction. The ability to communicate information about the presence of mitochondrial stress enables a global response that can ultimately better protect an organ...

journal_title：Cell

authors： Zhang Q,Wu X,Chen P,Liu L,Xin N,Tian Y,Dillin A

更新日期：2018-08-09 00:00:00

abstract：:A gel electrophoresis DNA binding assay has been used to identify proteins in HeLa cell extracts that specifically bind to the major late promoter of adenovirus. A major late promoter transcription factor MLTF has been detected as a discrete protein-DNA complex. MLTF binds specifically and with high affinity to sequen...

journal_title：Cell

authors： Carthew RW,Chodosh LA,Sharp PA

更新日期：1985-12-01 00:00:00

abstract：:The gut epithelium self-renews every several days, providing an important innate defense system that limits bacterial colonization. Nevertheless, many bacterial pathogens, including Shigella, efficiently colonize the intestinal epithelium. Here, we show that the Shigella effector IpaB, when delivered into epithelial c...

journal_title：Cell

authors： Iwai H,Kim M,Yoshikawa Y,Ashida H,Ogawa M,Fujita Y,Muller D,Kirikae T,Jackson PK,Kotani S,Sasakawa C

更新日期：2007-08-24 00:00:00

abstract：:The human immunodeficiency virus, the lentivirus that causes AIDS, is responsible for the most prevalent epidemic in the history of mankind. Here in this Timeline, we have attempted to illustrate a short history of HIV-1, from its identification in landmark papers published by Robert Gallo, Myron Essex, and Luc Montag...

journal_title：Cell

authors： Agarwal-Jans S

更新日期：2020-10-15 00:00:00

abstract：:The nucleotide sequence from the 5' terminus inward of one third of mouse alpha- and beta maj-globin messenger RNAs has been established. In addition, using 5' 32P end-labeled mRNAs as substrates and S1 and T1 nucleases as probes for single-stranded regions, the secondary structures of mouse and rabbit alpha- and beta...

journal_title：Cell

authors： Pavlakis GN,Lockard RE,Vamvakopoulos N,Rieser L,RajBhandary UL,Vournakis JN

更新日期：1980-01-01 00:00:00

abstract：:We show that transfer of human fibroblast chromosome 11 (containing the human MyoD gene) from primary cells into 10T1/2 mouse fibroblasts by microcell fusion activates expression of the transferred human MyoD gene and converts these cells to myoblasts. Transfer of human chromosome 11 into B78 melanoma cells also leads...

journal_title：Cell

authors： Thayer MJ,Weintraub H

更新日期：1990-10-05 00:00:00

abstract：:Expression of human immunodeficiency virus type 1 structural proteins requires both the viral Rev trans-activator and its cis-acting RNA target sequence, the Rev response element (RRE). The RRE has been mapped to a conserved region of the HIV-1 env gene and is predicted to form a complex, highly stable RNA stem-loop s...

journal_title：Cell

authors： Malim MH,Tiley LS,McCarn DF,Rusche JR,Hauber J,Cullen BR

更新日期：1990-02-23 00:00:00

abstract：:Dysregulation of splicing and alternative splicing underlies many genetic and acquired diseases. We present an overview of recent strategies and successes in modulating splicing therapeutically in clinical and preclinical contexts. Effective approaches include restoring open reading frames, influencing alternative spl...

journal_title：Cell

authors： Spitali P,Aartsma-Rus A

更新日期：2012-03-16 00:00:00

abstract：:How and when memory T cells form during an immune response are long-standing questions. To better understand memory CD8 T cell development, a time course of gene expression and functional changes in antigen-specific T cells during viral infection was evaluated. The expression of many genes continued to change after vi...

journal_title：Cell

authors： Kaech SM,Hemby S,Kersh E,Ahmed R

更新日期：2002-12-13 00:00:00

abstract：:We propose a mechanism for the priming of influenza viral RNA transcription by capped RNAs in which specific 5'-terminal fragments are cleaved from the capped RNAs by a virion-associated endonuclease. These fragments would serve as the actual primers for the initiation of transcription by the initial incorporation by ...

journal_title：Cell

authors： Plotch SJ,Bouloy M,Ulmanen I,Krug RM

更新日期：1981-03-01 00:00:00

abstract：:Ions serve as essential nutrients in higher plants and can also act as signaling molecules. Little is known about how plants sense changes in soil nutrient concentrations. Previous studies showed that T101-phosphorylated CHL1 is a high-affinity nitrate transporter, whereas T101-dephosphorylated CHL1 is a low-affinity ...

journal_title：Cell

authors： Ho CH,Lin SH,Hu HC,Tsay YF

更新日期：2009-09-18 00:00:00

abstract：:To test the functional consequence of phosphorylation of the EGF receptor at Thr 654 by protein kinase C, the normal Thr 654 human EGF receptor cDNA or a mutant encoding an Ala 654 were expressed in heterologous cells. In cell lines expressing both the Thr 654 and Ala 654 receptors, functional cell-surface Thr 654 rec...

journal_title：Cell

authors： Lin CR,Chen WS,Lazar CS,Carpenter CD,Gill GN,Evans RM,Rosenfeld MG

更新日期：1986-03-28 00:00:00

abstract：:Gold conjugates have been used to quantitate human transferrin receptors (hTfnRs) on transfected chick embryo fibroblasts. No relationship could be found between the number of hTfnRs and the number of clathrin-coated pits. However, hTfnRs are also associated with flat clathrin lattices that lie outside invaginated pit...

journal_title：Cell

authors： Miller K,Shipman M,Trowbridge IS,Hopkins CR

更新日期：1991-05-17 00:00:00

abstract：:Cholera toxin inhibition of progesterone-induced meiosis of Xenopus laevis oocytes in vitro has been correlated with increased cAMP levels. Inhibition of germinal vesicle breakdown (Gvbd) and cAMP increase occurred after a lag period of 2 hr, when cholera toxin was injected, or 4--5 hr, when applied externally. The ab...

journal_title：Cell

authors： Schorderet-Slatkine S,Schorderet M,Boquet P,Godeau F,Baulieu EE

更新日期：1978-12-01 00:00:00

abstract：:The sequence of about one third of the polyoma virus genome is presented. This sequence covers the origin of replication of two large plaque strains (A2 and A3) of polyoma virus. The two strains differ by 11 bp in the origin region. A model for replication is suggested. The sequence probably also covers the entire cod...

journal_title：Cell

authors： Soeda E,Arrand JR,Smolar N,Griffin BE

更新日期：1979-06-01 00:00:00

abstract：:An attenuated form of familial adenomatous polyposis coli, AAPC, causes relatively few colonic polyps, but still carries a significant risk of colon cancer. The mutant alleles responsible for this attenuated phenotype have been mapped in several families to the adenomatous polyposis coli (APC) locus on human chromosom...

journal_title：Cell

authors： Spirio L,Olschwang S,Groden J,Robertson M,Samowitz W,Joslyn G,Gelbert L,Thliveris A,Carlson M,Otterud B

更新日期：1993-12-03 00:00:00

abstract：:S. cerevisiae strains containing RAS2val19, a RAS2 gene with a missense mutation analogous to one that activates the transforming potential of mammalian ras genes, have growth and biochemical properties strikingly similar to yeast strains carrying IAC or bcy1. Yeast strains carrying the IAC mutation have elevated leve...

journal_title：Cell

authors： Toda T,Uno I,Ishikawa T,Powers S,Kataoka T,Broek D,Cameron S,Broach J,Matsumoto K,Wigler M

更新日期：1985-01-01 00:00:00

abstract：:Pulses of ecdysteroids direct Drosophila through its life cycle by activating stage- and tissue-specific genetic regulatory hierarchies. Here we show that an orphan nuclear receptor, DHR78, functions at the top of the ecdysteroid regulatory hierarchies. Null mutations in DHR78 lead to lethality during the third larval...

journal_title：Cell

authors： Fisk GJ,Thummel CS

更新日期：1998-05-15 00:00:00

abstract：:The crystal structure of the snake toxin fasciculin, bound to mouse acetylcholinesterase (mAChE), at 3.2 A resolution reveals a synergistic three-point anchorage consistent with the picomolar dissociation constant of the complex. Loop II of fasciculin contains a cluster of hydrophobic residues that interact with the p...

journal_title：Cell

authors： Bourne Y,Taylor P,Marchot P

更新日期：1995-11-03 00:00:00

abstract：:Vg1 is a TGF beta-related growth factor encoded by a maternal mRNA localized to vegetal blastomeres in Xenopus embryos. Vg1 precursor protein is abundant in vegetal cells, but the processed mature form has not been readily detected and no activity has been demonstrated for the putative Vg1 mature protein. We have engi...

journal_title：Cell

authors： Thomsen GH,Melton DA

更新日期：1993-08-13 00:00:00

abstract：:How metazoan mechanotransduction channels sense mechanical stimuli is not well understood. The NOMPC channel in the transient receptor potential (TRP) family, a mechanotransduction channel for Drosophila touch sensation and hearing, contains 29 Ankyrin repeats (ARs) that associate with microtubules. These ARs have bee...

journal_title：Cell

authors： Zhang W,Cheng LE,Kittelmann M,Li J,Petkovic M,Cheng T,Jin P,Guo Z,Göpfert MC,Jan LY,Jan YN

更新日期：2015-09-10 00:00:00

abstract：:Type I spiral ganglion neurons (SGNs) transmit sound information from cochlear hair cells to the CNS. Using transcriptome analysis of thousands of single neurons, we demonstrate that murine type I SGNs consist of subclasses that are defined by the expression of subsets of transcription factors, cell adhesion molecules...

journal_title：Cell

authors： Sun S,Babola T,Pregernig G,So KS,Nguyen M,Su SM,Palermo AT,Bergles DE,Burns JC,Müller U

更新日期：2018-08-23 00:00:00

abstract：:The Mre11-Rad50-Nbs1 (MRN) complex senses DNA double-strand breaks and recruits different repair pathway and checkpoint proteins to break foci. Two new studies (Williams et al., 2009; Lloyd et al., 2009) identify Nbs1 as a key factor in this process and reveal how an N-terminal protein recruitment module in Nbs1 binds...

journal_title：Cell

authors： Hopfner KP

更新日期：2009-10-02 00:00:00

abstract：:Telomeres of Oxytricha nova macronuclear chromosomes consist of a repeated T4G4 sequence, single-stranded at the 3' terminus, bound by a heterodimeric protein. The cloning of genes for the two polypeptides and their separate expression in E. coli have enabled evaluation of their individual contributions to DNA binding...

journal_title：Cell

authors： Gray JT,Celander DW,Price CM,Cech TR

更新日期：1991-11-15 00:00:00