Abstract：
:Pulses of ecdysteroids direct Drosophila through its life cycle by activating stage- and tissue-specific genetic regulatory hierarchies. Here we show that an orphan nuclear receptor, DHR78, functions at the top of the ecdysteroid regulatory hierarchies. Null mutations in DHR78 lead to lethality during the third larval instar with defects in ecdysteroid-triggered developmental responses. Consistent with these phenotypes, DHR78 mutants fail to activate the mid-third instar regulatory hierarchy that prepares the animal for metamorphosis. DHR78 protein is bound to many ecdysteroid-regulated puff loci, suggesting that DHR78 directly regulates puff gene expression. In addition, ectopic expression of DHR78 has no effects on development, indicating that its activity is regulated post-translationally. We propose that DHR78 is a ligand-activated receptor that plays a central role in directing the onset of Drosophila metamorphosis.
journal_name
Celljournal_title
Cellauthors
Fisk GJ,Thummel CSdoi
10.1016/s0092-8674(00)81184-8subject
Has Abstractpub_date
1998-05-15 00:00:00pages
543-55issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(00)81184-8journal_volume
93pub_type
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