Abstract：
:CD4 T cells potentiate the inflammatory or humoral immune response through the action of Th1 and Th2 cells, respectively. The molecular basis of the differentiation of these cells from naive T cell precursors is, however, unclear. We found that GATA-3 was selectively expressed in Th2 cells. GATA-3 is expressed at a high level in naive, freshly activated T cells and Th2 lineage cells, but subsides to a minimal level in Th1 lineage cells as naive cells commit to their Th subset. Antisense GATA-3 inhibited the expression of all Th2 cytokine genes in the Th2 clone D10. GATA-3 directly activated an IL-4 promoter-luciferase reporter gene in M12 cells. In transgenic mice, elevated GATA-3 in CD4 T cells caused Th2 cytokine gene expression in developing Th1 cells. Thus, GATA-3 is necessary and sufficient for Th2 cytokine gene expression.
journal_name
Celljournal_title
Cellauthors
Zheng W,Flavell RAdoi
10.1016/s0092-8674(00)80240-8subject
Has Abstractpub_date
1997-05-16 00:00:00pages
587-96issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(00)80240-8journal_volume
89pub_type
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