Abstract:
:In this issue of Cell, identify a first regulatory link between planar cell polarity (PCP) signaling and apical-basal polarity. The authors propose that a component of the apical Crumbs complex regulates the phosphorylation of the Frizzled (Fz) PCP receptor, thus modulating PCP in the Drosophila eye.
journal_name
Celljournal_title
Cellauthors
Schweisguth Fdoi
10.1016/j.cell.2005.05.006subject
Has Abstractpub_date
2005-05-20 00:00:00pages
497-499issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(05)00448-4journal_volume
121pub_type
评论,杂志文章,评审相关文献
CELL文献大全abstract::Evasion of DNA damage-induced cell death, via mutation of the p53 tumor suppressor or overexpression of prosurvival Bcl-2 family proteins, is a key step toward malignant transformation and therapeutic resistance. We report that depletion or acute inhibition of checkpoint kinase 1 (Chk1) is sufficient to restore gamma-...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2008.03.037
更新日期:2008-05-30 00:00:00
abstract::At the final step of homologous recombination, Holliday junction-containing joint molecules (JMs) are resolved to form crossover or noncrossover products. The enzymes responsible for JM resolution in vivo remain uncertain, but three distinct endonucleases capable of resolving JMs in vitro have been identified: Mus81-M...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.03.023
更新日期:2012-04-13 00:00:00
abstract::The "holobiont" concept, defined as the collective contribution of the eukaryotic and prokaryotic counterparts to the multicellular organism, introduces a complex definition of individuality enabling a new comprehensive view of human evolution and personalized characteristics. Here, we provide snapshots of the evolvin...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2017.11.024
更新日期:2017-12-14 00:00:00
abstract::Genetics and pharmacology can elicit surprisingly different phenotypes despite targeting the same protein. This Essay explores these unexpected differences and their implications for biology and medicine. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.01.021
更新日期:2007-02-09 00:00:00
abstract::Prion-like domains have emerged as important drivers of neurodegenerative disease. Now, Boulay et al. establish that the translocated prion-like domain of the oncogenic EWS-FLI1 fusion protein enables phase-separation events, which inappropriately recruit chromatin-remodeling factors to elicit the aberrant transcripti...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2017.09.010
更新日期:2017-09-21 00:00:00
abstract::The DDB1-CUL4-RBX1 (CRL4) ubiquitin ligase family regulates a diverse set of cellular pathways through dedicated substrate receptors (DCAFs). The DCAF DDB2 detects UV-induced pyrimidine dimers in the genome and facilitates nucleotide excision repair. We provide the molecular basis for DDB2 receptor-mediated cyclobutan...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2011.10.035
更新日期:2011-11-23 00:00:00
abstract::Chromosomal translocations between antigen receptor loci and oncogenes are a hallmark of lymphoid cancers. Several new studies now reveal that programmed DNA breaks created during assembly of antigen receptor genes can be channeled into an alternative DNA end-joining pathway that is implicated in the chromosomal trans...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.10.005
更新日期:2007-10-19 00:00:00
abstract::Type I spiral ganglion neurons (SGNs) transmit sound information from cochlear hair cells to the CNS. Using transcriptome analysis of thousands of single neurons, we demonstrate that murine type I SGNs consist of subclasses that are defined by the expression of subsets of transcription factors, cell adhesion molecules...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.07.008
更新日期:2018-08-23 00:00:00
abstract::A new type of mutation that affects a discrete step in the process of adsorptive endocytosis has been identified in one of 22 strains of fibroblasts derived from subjects with the clinical phenotype of homozygous familial hypercholesterolemia (FH). In this unique mutant strain (derived from subject J.D.), the cell sur...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(76)90130-6
更新日期:1976-12-01 00:00:00
abstract::The segment polarity genes engrailed and wingless are expressed in neighboring stripes of cells on opposite sides of the Drosophila parasegment boundary. Each gene is mutually required for maintenance of the other's expression; continued expression of both also requires several other segment polarity genes. We show he...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90264-d
更新日期:1992-10-02 00:00:00
abstract::SecA, the peripheral subunit of E. coli preprotein translocase, alternates between a membrane inserted and a deinserted state as part of the catalytic cycle of preprotein translocation. When SecA is complexed with SecY/E and preprotein, ATP drives a profound conformational change, leading to membrane insertion of a 30...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(94)90582-7
更新日期:1994-09-09 00:00:00
abstract::A comprehensive analysis uncovered a set of yeast proteins promoting protein-based inheritance that shares many of the non-Mendelian properties of prions. Lacking any sequence or structural signatures of known prions, these proteins represent a new class of non-amyloid, protein-based epigenetic determinants that can c...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2016.09.036
更新日期:2016-10-06 00:00:00
abstract::Nuclear exclusion of the forkhead transcription factor FOXO3a by protein kinase Akt contributes to cell survival. We investigated the pathological relationship between phosphoylated-Akt (Akt-p) and FOXO3a in primary tumors. Surprisingly, FOXO3a was found to be excluded from the nuclei of some tumors lacking Akt-p, sug...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(04)00302-2
更新日期:2004-04-16 00:00:00
abstract::Bcl-2 protein is able to repress a number of apoptotic death programs. To investigate the mechanism of Bcl-2's effect, we examined whether Bcl-2 interacted with other proteins. We identified an associated 21 kd protein partner, Bax, that has extensive amino acid homology with Bcl-2, focused within highly conserved dom...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(93)90509-o
更新日期:1993-08-27 00:00:00
abstract::Gastrulation is a complex process requiring the coordination of cell shape changes and cell movements. In Drosophila, gastrulation begins immediately upon cellularization of the blastoderm stage embryo with the formation of the ventral furrow and posterior midgut. Cells that form both of these invaginations change the...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90652-f
更新日期:1991-01-25 00:00:00
abstract::We have employed repeat units of herpes simplex virus (HSV) defective genomes to derive a cloning-amplifying vector (amplicon) that can replicate in eucaryotic cells in the presence of standard HSV helper virus. The design of the HSV amplicon system is based on the previous observation that cotransfection of cells wit...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90035-6
更新日期:1982-08-01 00:00:00
abstract::The amino acid glutamine has a central role in nitrogen metabolism. Although the molecular mechanisms responsible for its transport across cell membranes remain poorly understood, classical amino acid transport system N appears particularly important. Using intracellular pH measurements, we have now identified an orph...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81674-8
更新日期:1999-12-23 00:00:00
abstract::In developing organisms, spatially prescribed cell identities are thought to be determined by the expression levels of multiple genes. Quantitative tests of this idea, however, require a theoretical framework capable of exposing the rules and precision of cell specification over developmental time. We use the gap gene...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.01.007
更新日期:2019-02-07 00:00:00
abstract::Hybrid transducing phages were constructed in vitro that carry the galK gene fused to each of three ribosomal promoters: the promotor for an rRNA operon (rrnE); the promoter for the spec r protein operon and the promotor for the alpha r protein operon. We also constructed hybrid transducing phages that carry the IacZ ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90185-9
更新日期:1981-09-01 00:00:00
abstract::In April this year, a new influenza virus of swine origin emerged in Mexico and spread rapidly around the world. As the Northern hemisphere winter flu season kicks off, Laura Vargas-Parada reports on the measures that Mexico is taking to combat the H1N1 pandemic. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.12.019
更新日期:2009-12-24 00:00:00
abstract::To determine whether phylogenetically conservative H-Y antigen plays any part in gonadal differentiation among the nonmammalian vertebrates, we studied expression and binding of H-Y in the frog, Xenopus laevis. Soluble H-Y obtained from mouse testis and soluble H-W from chicken ovary bound specifically to cells of the...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(80)90332-3
更新日期:1980-07-01 00:00:00
abstract::Brassinosteroids (BRs) signal through a plasma membrane-localized receptor kinase to regulate plant growth and development. We showed previously that a novel protein, BES1, accumulates in the nucleus in response to BRs, where it plays a role in BR-regulated gene expression; however, the mechanism by which BES1 regulat...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2004.11.044
更新日期:2005-01-28 00:00:00
abstract::Negative feedback is a widespread feature of signaling pathways. In an unexpected twist described in this issue, He and colleagues identify a membrane-tethered metalloprotease named Tiki that inhibits Wnt signaling by removing an essential eight-residue fragment from Wnt itself. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2012.06.007
更新日期:2012-06-22 00:00:00
abstract::The PML tumor suppressor controls key pathways for growth suppression, induction of apoptosis, and cellular senescence. PML loss occurs frequently in human tumors through unknown posttranslational mechanisms. Casein kinase 2 (CK2) is oncogenic and frequently upregulated in human tumors. Here we show that CK2 regulates...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.05.041
更新日期:2006-07-28 00:00:00
abstract::Treatment of guinea pig neutrophils with pertussis toxin (islet-activating protein; IAP) results in inhibition of N-formyl peptide receptor-mediated release of arachidonic acid and granular enzymes. Inhibition by the toxin is specific, in that responses to the calcium ionophore A23187 are not affected. The action of t...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90008-4
更新日期:1984-12-01 00:00:00
abstract::Cellular compartments that cannot be biochemically isolated are challenging to characterize. Here we demonstrate the proteomic characterization of the synaptic clefts that exist at both excitatory and inhibitory synapses. Normal brain function relies on the careful balance of these opposing neural connections, and und...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.07.041
更新日期:2016-08-25 00:00:00
abstract::Resident proteins of the ER lumen carry a specific tetrapeptide signal (KDEL or HDEL) that prevents their secretion. We have previously described the isolation of yeast mutants that fail to retain such resident proteins within the cell. Here we describe ERD2, a gene required for retention. It encodes a 26 kd integral ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90698-e
更新日期:1990-06-29 00:00:00
abstract::During HIV infection, the timing of opportunistic infections is not always associated with severity of CD4 T cell depletion, and different opportunistic pathogens reactivate at different CD4 T cell thresholds. Here, we examine how differences in the phenotype and function of pathogen-specific CD4 T cells influence sus...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.09.045
更新日期:2013-10-24 00:00:00
abstract::Nuclear hormone receptors comprise a superfamily of ligand-modulated transcription factors that mediate the transcriptional activities of steroids, retinoids, and thyroid hormones. A growing number of related proteins have been identified that possess the structural features of hormone receptors, but that lack known l...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90530-8
更新日期:1995-06-02 00:00:00
abstract::Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P. aeruginosa toward clinically relevant antibiotics leads to phenotypic convergence toward distinct states. These states are associated w...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.12.012
更新日期:2018-01-11 00:00:00