Abstract:
:Prion-like domains have emerged as important drivers of neurodegenerative disease. Now, Boulay et al. establish that the translocated prion-like domain of the oncogenic EWS-FLI1 fusion protein enables phase-separation events, which inappropriately recruit chromatin-remodeling factors to elicit the aberrant transcriptional programs underlying Ewing's sarcoma.
journal_name
Celljournal_title
Cellauthors
Shorter Jdoi
10.1016/j.cell.2017.09.010subject
Has Abstractpub_date
2017-09-21 00:00:00pages
30-31issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(17)31059-0journal_volume
171pub_type
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