Abstract：
:Transplantation of pronuclei between one-cell-stage embryos was used to construct diploid mouse embryos with two female pronuclei ( biparental gynogenones ) or two male pronuclei ( biparental androgenones ). The ability of these embryos to develop to term was compared with control nuclear-transplant embryos in which the male or the female pronucleus was replaced with an isoparental pronucleus from another embryo. The results show that diploid biparental gynogenetic and androgenetic embryos do not complete normal embryogenesis, whereas control nuclear transplant embryos do. We conclude that the maternal and paternal contributions to the embryonic genome in mammals are not equivalent and that a diploid genome derived from only one of the two parental sexes is incapable of supporting complete embryogenesis.
journal_name
Celljournal_title
Cellauthors
McGrath J,Solter Ddoi
10.1016/0092-8674(84)90313-1subject
Has Abstractpub_date
1984-05-01 00:00:00pages
179-83issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(84)90313-1journal_volume
37pub_type
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