Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription.

abstract：:We investigated a herpesvirus mutant that contains a single base insertion in its thymidine kinase (tk) gene yet expresses low levels of TK via a net +1 translational recoding event. Within this mutant gene, we defined a G-rich signal that is sufficient to induce recoding. Unlike other translational recoding events, d...

journal_title：Cell

authors： Horsburgh BC,Kollmus H,Hauser H,Coen DM

更新日期：1996-09-20 00:00:00

abstract：:Type 2 (non-insulin-dependent) diabetes mellitus is a progressive metabolic disorder arising from genetic and environmental factors that impair beta cell function and insulin action in peripheral tissues. We identified reduced diacylglycerol kinase delta (DGKdelta) expression and DGK activity in skeletal muscle from t...

journal_title：Cell

authors： Chibalin AV,Leng Y,Vieira E,Krook A,Björnholm M,Long YC,Kotova O,Zhong Z,Sakane F,Steiler T,Nylén C,Wang J,Laakso M,Topham MK,Gilbert M,Wallberg-Henriksson H,Zierath JR

更新日期：2008-02-08 00:00:00

abstract：:Fragile X syndrome results from the expansion of a CGG repeat that is normally interrupted by occasional AGG triplets. Linkage disequilibrium suggests that certain normal haplotypes may contribute unequally to the pool of fragile X chromosomes. Sequence analysis of normal alleles demonstrates haplotype-specific variat...

journal_title：Cell

authors： Kunst CB,Warren ST

更新日期：1994-06-17 00:00:00

abstract：:The COVID-19 pandemic has led to extensive morbidity and mortality throughout the world. Clinical features that drive SARS-CoV-2 pathogenesis in humans include inflammation and thrombosis, but the mechanistic details underlying these processes remain to be determined. In this study, we demonstrate endothelial disrupti...

journal_title：Cell

authors： Aid M,Busman-Sahay K,Vidal SJ,Maliga Z,Bondoc S,Starke C,Terry M,Jacobson CA,Wrijil L,Ducat S,Brook OR,Miller AD,Porto M,Pellegrini KL,Pino M,Hoang TN,Chandrashekar A,Patel S,Stephenson K,Bosinger SE,Andersen H,

更新日期：2020-11-25 00:00:00

abstract：:Mammalian cells express a spectrum of tubulin isotypes whose relationship to the diversity of microtubule function is unknown. To examine whether different isotypes are segregated into functionally distinct microtubules, we generated immune sera capable of discriminating among the various naturally occurring beta-tubu...

journal_title：Cell

authors： Lewis SA,Gu W,Cowan NJ

更新日期：1987-05-22 00:00:00

abstract：:Characterizing cell surface receptors mediating viral infection is critical for understanding viral tropism and developing antiviral therapies. Nevertheless, due to challenges associated with detecting protein interactions on the cell surface, the host receptors of many human pathogens remain unknown. Here, we build a...

journal_title：Cell

authors： Martinez-Martin N,Marcandalli J,Huang CS,Arthur CP,Perotti M,Foglierini M,Ho H,Dosey AM,Shriver S,Payandeh J,Leitner A,Lanzavecchia A,Perez L,Ciferri C

更新日期：2018-08-23 00:00:00

abstract：:Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTE...

journal_title：Cell

authors： Ciriello G,Gatza ML,Beck AH,Wilkerson MD,Rhie SK,Pastore A,Zhang H,McLellan M,Yau C,Kandoth C,Bowlby R,Shen H,Hayat S,Fieldhouse R,Lester SC,Tse GM,Factor RE,Collins LC,Allison KH,Chen YY,Jensen K,Johnson NB,O

更新日期：2015-10-08 00:00:00

abstract：:Protease-activated receptors (PARs) are a unique class of G protein-coupled receptors that play critical roles in thrombosis, inflammation, and vascular biology. PAR1 is proposed to be involved in the invasive and metastatic processes of various cancers. However, the protease responsible for activating the proinvasive...

journal_title：Cell

authors： Boire A,Covic L,Agarwal A,Jacques S,Sherifi S,Kuliopulos A

更新日期：2005-02-11 00:00:00

abstract：:After three or more passages, stromal cell outgrowths from explants of normal rabbit corneas and from corneas previously burned with alkali did not produce collagenase until they were stimulated by the addition of rabbit blood-derived mononuclear cells or media conditioned by them. Normal stromal cells required stimul...

journal_title：Cell

authors： Newsome DA,Gross J

更新日期：1979-04-01 00:00:00

abstract：:Clonal derivatives of C3HMT murine mammary cell lines in culture demonstrate conversion of mammary tumor virus (MMTV) expression at a rate of appriximately 6 per 100 clones. This alteration is largely unidirectional from a relatively high level (MMTV(H)) to a 10 fold lower level (MMTV(L)). This high rate of MMTV(L) va...

journal_title：Cell

authors： Parks WP,Hubbell ES,Goldberg RJ,O'Neill FJ,Scolnick EM

更新日期：1976-05-01 00:00:00

abstract：:Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads to an increase in the N...

journal_title：Cell

authors： Soleimanpour SA,Gupta A,Bakay M,Ferrari AM,Groff DN,Fadista J,Spruce LA,Kushner JA,Groop L,Seeholzer SH,Kaufman BA,Hakonarson H,Stoffers DA

更新日期：2014-06-19 00:00:00

abstract：:A "switch" from oxidative phosphorylation (OXPHOS) to aerobic glycolysis is a hallmark of T cell activation and is thought to be required to meet the metabolic demands of proliferation. However, why proliferating cells adopt this less efficient metabolism, especially in an oxygen-replete environment, remains incomplet...

journal_title：Cell

authors： Chang CH,Curtis JD,Maggi LB Jr,Faubert B,Villarino AV,O'Sullivan D,Huang SC,van der Windt GJ,Blagih J,Qiu J,Weber JD,Pearce EJ,Jones RG,Pearce EL

更新日期：2013-06-06 00:00:00

abstract：:TGF-beta signaling controls a plethora of cellular responses and figures prominently in animal development. Recent cellular, biochemical, and structural studies have revealed significant insight into the mechanisms of the activation of TGF-beta receptors through ligand binding, the activation of Smad proteins through ...

journal_title：Cell

authors： Shi Y,Massagué J

更新日期：2003-06-13 00:00:00

abstract：:Centrosomes are non-membrane-bound compartments that nucleate microtubule arrays. They consist of nanometer-scale centrioles surrounded by a micron-scale, dynamic assembly of protein called the pericentriolar material (PCM). To study how PCM forms a spherical compartment that nucleates microtubules, we reconstituted P...

journal_title：Cell

authors： Woodruff JB,Ferreira Gomes B,Widlund PO,Mahamid J,Honigmann A,Hyman AA

更新日期：2017-06-01 00:00:00

abstract：:Childhood asthma is typically associated with a polarized Th2 response to inhaled allergens and is influenced by genetics. Yang et al. show that the asthma susceptibility gene DENND1B controls cytokine production in Th2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes, providing a mo...

journal_title：Cell

authors： Godar M,Lambrecht BN

更新日期：2016-01-14 00:00:00

abstract：:We have fused DNA fragments derived from an Escherichia coli tRNALeu1 operon to the galK gene of E. coli to identify sequences necessary for the in vivo initiation of transcription and growth-rate-dependent regulation. Promoter sequences consisting of residues from -50 to +56 or -50 to +5 with respect to the in vivo s...

journal_title：Cell

authors： Duester G,Elford RM,Holmes WM

更新日期：1982-10-01 00:00:00

abstract：:We have reproduced the posttranslational mode of protein translocation across the endoplasmic reticulum membrane with reconstituted proteoliposomes containing a purified complex of seven yeast proteins. This Sec complex includes a heterotrimeric Sec61p complex, homologous to that in mammals, as well as all other membr...

journal_title：Cell

authors： Panzner S,Dreier L,Hartmann E,Kostka S,Rapoport TA

更新日期：1995-05-19 00:00:00

abstract：:Dietary soluble fibers are fermented by gut bacteria into short-chain fatty acids (SCFA), which are considered broadly health-promoting. Accordingly, consumption of such fibers ameliorates metabolic syndrome. However, incorporating soluble fiber inulin, but not insoluble fiber, into a compositionally defined diet, ind...

journal_title：Cell

authors： Singh V,Yeoh BS,Chassaing B,Xiao X,Saha P,Aguilera Olvera R,Lapek JD Jr,Zhang L,Wang WB,Hao S,Flythe MD,Gonzalez DJ,Cani PD,Conejo-Garcia JR,Xiong N,Kennett MJ,Joe B,Patterson AD,Gewirtz AT,Vijay-Kumar M

更新日期：2018-10-18 00:00:00

abstract：:In the mouse, the zona pellucida (ZP) glycoprotein ZP3 both binds intact sperm and induces acrosomal exocytosis. The subsequent signaling pathway(s) is still uncertain, but Gi-like proteins have been implicated. By analogy with other signal transduction mechanisms, we examined anti-phosphotyrosine antibody reactivity ...

journal_title：Cell

authors： Leyton L,Saling P

更新日期：1989-06-30 00:00:00

abstract：:We predict regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs with near complementarity. Complementary sites within predicted targets are conserved in rice. Of the 49 predicted targets, 34 are members of transcription factor gene families involved in developmental patterning or cell differen...

journal_title：Cell

authors： Rhoades MW,Reinhart BJ,Lim LP,Burge CB,Bartel B,Bartel DP

更新日期：2002-08-23 00:00:00

abstract：:In this issue of Cell, Shin et al. report the first live-cell imaging of a fusion pore. Directly visualized pores in neuroendocrine cells can be much larger than expected yet not require vesicular full-collapse. These fusion-fission pores have diverse fates arising from opposing dynamin-driven pore constriction and F-...

journal_title：Cell

authors： Eyring KW,Tsien RW

更新日期：2018-05-03 00:00:00

abstract：:AU-rich elements (AREs), present in mRNA 3'-UTRs, are potent posttranscriptional regulatory signals that can rapidly effect changes in mRNA stability and translation, thereby dramatically altering gene expression with clinical and developmental consequences. In human cell lines, the TNFalpha ARE enhances translation r...

journal_title：Cell

authors： Vasudevan S,Steitz JA

更新日期：2007-03-23 00:00:00

abstract：:Mutant strains of D. discoideum are described that can complete morphogenesis and cytodifferentiation but which express vastly reduced levels of the galactose-binding lectins discoidin I and II (less than 1% and 1%-2% respectively) compared to the wild-type control. Mutant cells proceeding through development lack lec...

journal_title：Cell

authors： Alexander S,Shinnick TM,Lerner RA

更新日期：1983-09-01 00:00:00

abstract：:We describe the isolation and characterization of two unusual amber suppressor forms of T4 tRNALeu. The sequences of the suppressor tRNAs can be described as hybrids of wild-type tRNALeu and suppressor tRNAGln molecules: the chain lengths and majority of the nucleotide residues corresponded to tRNALeu, but CUA anticod...

journal_title：Cell

authors： McClain WH,Foss K

更新日期：1984-08-01 00:00:00

abstract：:In target tissues for estrogen, including breast cancer cells, the synthesis of progesterone receptors (PRs) is controlled by estradiol acting through estrogen receptors (ERs). We describe studies with T47D human breast cancer cells, whose PRs are not regulated by estradiol, though present in extraordinary amounts (30...

journal_title：Cell

authors： Horwitz KB,Mockus MB,Lessey BA

更新日期：1982-03-01 00:00:00

abstract：:We have identified and analyzed a meiotic reciprocal recombination hot spot in S. cerevisiae. We find that double-strand breaks occur at two specific sites associated with the hot spot and that occurrence of these breaks depends upon meiotic recombination functions RAD50 and SPO11. Furthermore, these breaks occur in a...

journal_title：Cell

authors： Cao L,Alani E,Kleckner N

更新日期：1990-06-15 00:00:00

abstract：:Ku is a heterodimeric DNA end binding complex composed of 70 and 86 kDa subunits. Here, we show that Ku86 is essential for normal V(D)J recombination in vivo, as Ku86-deficient mice are severely defective for formation of coding joints. Unlike severe combined immunodeficient (scid) mice, Ku86-deficient mice are also d...

journal_title：Cell

authors： Zhu C,Bogue MA,Lim DS,Hasty P,Roth DB

更新日期：1996-08-09 00:00:00

abstract：:mRNA made in eukaryotic cells typically has a 3' poly(A) tail that is added posttranscriptionally. To investigate mechanisms by which 3' poly(A) is formed, we identified the genes for the two vaccina virus-encoded polypeptides, VP55 and VP39. Primer-dependent polyadenylation activity was associated exclusively with pu...

journal_title：Cell

authors： Gershon PD,Ahn BY,Garfield M,Moss B

更新日期：1991-09-20 00:00:00

abstract：:Oligodendrocyte-specific protein (OSP)/claudin-11 is a recently identified transmembrane protein found in CNS myelin and testis with unknown function. Herein we demonstrate that Osp null mice exhibit both neurological and reproductive deficits: CNS nerve conduction is slowed, hindlimb weakness is conspicuous, and male...

journal_title：Cell

authors： Gow A,Southwood CM,Li JS,Pariali M,Riordan GP,Brodie SE,Danias J,Bronstein JM,Kachar B,Lazzarini RA

更新日期：1999-12-10 00:00:00

abstract：:In order to identify nucleotide sequences required for efficient and accurate polyadenylation of mRNA precursors, we have constructed a series of mutations in the X. laevis beta 1-globin gene and analyzed transcripts produced upon microinjection into Xenopus oocytes. Small deletion and linker replacement mutations, wh...

journal_title：Cell

authors： Mason PJ,Elkington JA,Lloyd MM,Jones MB,Williams JG

更新日期：1986-07-18 00:00:00