Regulation of corneal collagenase production: stimulation of serially passaged stromal cells by blood mononuclear cells.

Abstract:

:After three or more passages, stromal cell outgrowths from explants of normal rabbit corneas and from corneas previously burned with alkali did not produce collagenase until they were stimulated by the addition of rabbit blood-derived mononuclear cells or media conditioned by them. Normal stromal cells required stimulation by lymphocytes or their products from alkali-burned animals, whereas those from alkali-burned corneas were stimulated by lymphocytes from either normal or alkali-burned rabbits.

journal_name

Cell

journal_title

Cell

authors

Newsome DA,Gross J

doi

10.1016/0092-8674(79)90104-1

subject

Has Abstract

pub_date

1979-04-01 00:00:00

pages

895-900

issue

4

eissn

0092-8674

issn

1097-4172

pii

0092-8674(79)90104-1

journal_volume

16

pub_type

杂志文章

相关文献

CELL文献大全
  • Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.

    abstract::Signaling by the epidermal growth factor receptor requires an allosteric interaction between the kinase domains of two receptors, whereby one activates the other. We show that the intracellular juxtamembrane segment of the receptor, known to potentiate kinase activity, is able to dimerize the kinase domains. The C-ter...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2009.04.025

    authors: Jura N,Endres NF,Engel K,Deindl S,Das R,Lamers MH,Wemmer DE,Zhang X,Kuriyan J

    更新日期:2009-06-26 00:00:00

  • The hunger genes: pathways to obesity.

    abstract::The global rise in the prevalence of obesity and associated co-morbidities such as type 2 diabetes, cardiovascular disease, and cancer represents a major public health concern. The biological response to increased consumption of palatable foods or a reduction in energy expenditure is highly variable between individual...

    journal_title:Cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.cell.2015.03.008

    authors: van der Klaauw AA,Farooqi IS

    更新日期:2015-03-26 00:00:00

  • The Viviparous-1 developmental gene of maize encodes a novel transcriptional activator.

    abstract::The Viviparous-1 (Vp1) gene of maize is specifically required for expression of the maturation program in seed development. We show that Vp1 encodes a 73,335 dalton protein with no detectable homology to known proteins. An acidic transcriptional activation sequence was identified by fusion to the GAL4 DNA-binding doma...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(91)90436-3

    authors: McCarty DR,Hattori T,Carson CB,Vasil V,Lazar M,Vasil IK

    更新日期:1991-09-06 00:00:00

  • Negative control of the helix-loop-helix family of myogenic regulators in the NFB mutant.

    abstract::We have characterized a nondifferentiating mouse muscle cell line, NFB, that represses the activity of the helix-loop-helix (HLH) family of myogenic regulators, yet expresses sarcomeric actins. The NFB MyoD gene is silent, but can be activated upon transfection of a long terminal region-controlled chicken MyoD cDNA, r...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(90)90014-6

    authors: Peterson CA,Gordon H,Hall ZW,Paterson BM,Blau HM

    更新日期:1990-08-10 00:00:00

  • Fertile waters for aging research.

    abstract::The quest to slow aging has come far, and what used to be the domain of science fiction writers and snake oil salesmen may soon become science fact. Innovative new approaches, such as the use of the very short-lived African killifish (Harel et al.), are bridging the translational gap and bring the promise of healthy l...

    journal_title:Cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.cell.2015.02.026

    authors: Wang AM,Promislow DEL,Kaeberlein M

    更新日期:2015-02-26 00:00:00

  • Scrapie prion protein contains a phosphatidylinositol glycolipid.

    abstract::The scrapie (PrPSc) and cellular (PrPC) prion proteins are encoded by the same gene, and their different properties are thought to arise from posttranslational modifications. We have found a phosphatidylinositol glycolipid on both PrPC and PrP 27-30 (derived from PrPSc by limited proteolysis at the amino terminus). Et...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(87)90150-4

    authors: Stahl N,Borchelt DR,Hsiao K,Prusiner SB

    更新日期:1987-10-23 00:00:00

  • Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome.

    abstract::The p53 tumor suppressor gene is commonly altered in human tumors, predominantly through missense mutations that result in accumulation of mutant p53 protein. These mutations may confer dominant-negative or gain-of-function properties to p53. To ascertain the physiological effects of p53 point mutation, the structural...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2004.11.004

    authors: Olive KP,Tuveson DA,Ruhe ZC,Yin B,Willis NA,Bronson RT,Crowley D,Jacks T

    更新日期:2004-12-17 00:00:00

  • Genetic analysis of the hormonally regulated yolk polypeptide genes in D. melanogaster.

    abstract::To initiate a genetic study of the hormonal regulation of genes coding for the three vitellogenins or yolk polypeptide precursors (YPs) in Drosophila, we have isolated from wild flies genetic variants which alter the mobility in SDS-PAGE of each YP independently. These variants are expressed codominantly and they are ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(80)90313-x

    authors: Postlethwait JH,Jowett T

    更新日期:1980-07-01 00:00:00

  • Growth rate-dependent global effects on gene expression in bacteria.

    abstract::Bacterial gene expression depends not only on specific regulatory mechanisms, but also on bacterial growth, because important global parameters such as the abundance of RNA polymerases and ribosomes are all growth-rate dependent. Understanding of these global effects is necessary for a quantitative understanding of ge...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2009.12.001

    authors: Klumpp S,Zhang Z,Hwa T

    更新日期:2009-12-24 00:00:00

  • Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

    abstract::The biguanide drug metformin is widely prescribed to treat type 2 diabetes and metabolic syndrome, but its mode of action remains uncertain. Metformin also increases lifespan in Caenorhabditis elegans cocultured with Escherichia coli. This bacterium exerts complex nutritional and pathogenic effects on its nematode pre...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2013.02.035

    authors: Cabreiro F,Au C,Leung KY,Vergara-Irigaray N,Cochemé HM,Noori T,Weinkove D,Schuster E,Greene ND,Gems D

    更新日期:2013-03-28 00:00:00

  • Restriction sites containing CpG show a higher frequency of polymorphism in human DNA.

    abstract::Unique loci in the human genome were examined with restriction enzymes in order to detect restriction fragment length polymorphisms (RFLPs). Of 31 arbitrary loci, nine were detectably polymorphic, reflecting ten polymorphic restriction sites. Nine of the ten polymorphic sites were revealed with two restriction enzymes...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(84)90081-3

    authors: Barker D,Schafer M,White R

    更新日期:1984-01-01 00:00:00

  • Saturated Reconstruction of a Volume of Neocortex.

    abstract::We describe automated technologies to probe the structure of neural tissue at nanometer resolution and use them to generate a saturated reconstruction of a sub-volume of mouse neocortex in which all cellular objects (axons, dendrites, and glia) and many sub-cellular components (synapses, synaptic vesicles, spines, spi...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2015.06.054

    authors: Kasthuri N,Hayworth KJ,Berger DR,Schalek RL,Conchello JA,Knowles-Barley S,Lee D,Vázquez-Reina A,Kaynig V,Jones TR,Roberts M,Morgan JL,Tapia JC,Seung HS,Roncal WG,Vogelstein JT,Burns R,Sussman DL,Priebe CE,Pfister H

    更新日期:2015-07-30 00:00:00

  • Deconvolving the recognition of DNA shape from sequence.

    abstract::Protein-DNA binding is mediated by the recognition of the chemical signatures of the DNA bases and the 3D shape of the DNA molecule. Because DNA shape is a consequence of sequence, it is difficult to dissociate these modes of recognition. Here, we tease them apart in the context of Hox-DNA binding by mutating residues...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2015.02.008

    authors: Abe N,Dror I,Yang L,Slattery M,Zhou T,Bussemaker HJ,Rohs R,Mann RS

    更新日期:2015-04-09 00:00:00

  • Monoclonal antibodies: use to detect developmentally regulated antigens on D. discoideum amebae.

    abstract::We have used monoclonal antibodies to detect developmentally regulated cell surface antigens on D. discoideum amebae. A study of an antigen detected using an antibody produced by a hybridoma line implicates a previously undescribed component in the process of cell aggregation. This antigen (consisting of a doublet of ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(83)90295-7

    authors: Brodie C,Klein C,Swierkosz J

    更新日期:1983-04-01 00:00:00

  • Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain.

    abstract::The function of somatic stem cells declines with age. Understanding the molecular underpinnings of this decline is key to counteract age-related disease. Here, we report a dramatic drop in the neural stem cells (NSCs) number in the aging murine brain. We find that this smaller stem cell reservoir is protected from ful...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2019.01.040

    authors: Kalamakis G,Brüne D,Ravichandran S,Bolz J,Fan W,Ziebell F,Stiehl T,Catalá-Martinez F,Kupke J,Zhao S,Llorens-Bobadilla E,Bauer K,Limpert S,Berger B,Christen U,Schmezer P,Mallm JP,Berninger B,Anders S,Del Sol A,Marc

    更新日期:2019-03-07 00:00:00

  • SGV1 encodes a CDC28/cdc2-related kinase required for a G alpha subunit-mediated adaptive response to pheromone in S. cerevisiae.

    abstract::The GPA1 gene of S. cerevisiae encodes a G alpha subunit that plays a positive role in the transduction of signals stimulating recovery from pheromone-induced cell cycle arrest. The GPA1Val50 mutation, in which Gly-50 is replaced by valine, causes hyperadaptation to pheromone. However, GPA1Val50 cells do not recover f...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(91)90386-d

    authors: Irie K,Nomoto S,Miyajima I,Matsumoto K

    更新日期:1991-05-31 00:00:00

  • Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways.

    abstract::The mechanisms by which molecular chaperones assist quality control of cytosolic proteins are poorly understood. Analysis of the chaperone requirements for degradation of misfolded variants of a cytosolic protein, the VHL tumor suppressor, reveals that distinct chaperone pathways mediate its folding and quality contro...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2005.03.024

    authors: McClellan AJ,Scott MD,Frydman J

    更新日期:2005-06-03 00:00:00

  • Mistranslation in a eucaryotic organism.

    abstract::Previous work from our laboratory has demonstrated that a subclass of the aminoglycoside antibiotics, those containing the drug fragment paromamine, stimulates mistranslation in cell-free protein-synthesizing systems derived from eucaryotic cells. We report here experiments which show that the ciliate Tetrahymena ther...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(78)90201-5

    authors: Palmer E,Wilhelm JM

    更新日期:1978-02-01 00:00:00

  • Small RNAs of opposite sign… but same absolute value.

    abstract::In ciliates, small RNAs have been shown to target foreign sequences for silencing via elimination from the somatic genome. Fang et al. now reveal a set of Piwi-interacting RNAs (piRNAs) in Oxytricha trifallax that likewise enable genomic self versus nonself discrimination, this time by specifying self sequences for ge...

    journal_title:Cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.cell.2012.11.032

    authors: Sontheimer EJ

    更新日期:2012-12-07 00:00:00

  • Sequence from early region of polyoma virus DNA containing viral replication origin and encoding small, middle and (part of) large T antigens.

    abstract::The sequence of about one third of the polyoma virus genome is presented. This sequence covers the origin of replication of two large plaque strains (A2 and A3) of polyoma virus. The two strains differ by 11 bp in the origin region. A model for replication is suggested. The sequence probably also covers the entire cod...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(79)90162-4

    authors: Soeda E,Arrand JR,Smolar N,Griffin BE

    更新日期:1979-06-01 00:00:00

  • The piRNA Response to Retroviral Invasion of the Koala Genome.

    abstract::Antisense Piwi-interacting RNAs (piRNAs) guide silencing of established transposons during germline development, and sense piRNAs drive ping-pong amplification of the antisense pool, but how the germline responds to genome invasion is not understood. The KoRV-A gammaretrovirus infects the soma and germline and is swee...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2019.09.002

    authors: Yu T,Koppetsch BS,Pagliarani S,Johnston S,Silverstein NJ,Luban J,Chappell K,Weng Z,Theurkauf WE

    更新日期:2019-10-17 00:00:00

  • Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest.

    abstract::The liver is capable of completely regenerating itself in response to injury and after partial hepatectomy. In liver of old animals, the proliferative response is dramatically reduced, the mechanism for which is unknown. The liver specific protein, C/EBPalpha, normally arrests proliferation of hepatocytes through inhi...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(03)00318-0

    authors: Iakova P,Awad SS,Timchenko NA

    更新日期:2003-05-16 00:00:00

  • Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

    abstract::Loss of cell cycle control and acquisition of chromosomal rearrangements such as gene amplification often occur during tumor progression, suggesting that they may be correlated. We show here that the wild-type p53 allele is lost when fibroblasts from patients with the Li-Fraumeni syndrome (LFS) are passaged in vitro. ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(92)90244-7

    authors: Yin Y,Tainsky MA,Bischoff FZ,Strong LC,Wahl GM

    更新日期:1992-09-18 00:00:00

  • Cells respond to mechanical stress by rapid disassembly of caveolae.

    abstract::The functions of caveolae, the characteristic plasma membrane invaginations, remain debated. Their abundance in cells experiencing mechanical stress led us to investigate their role in membrane-mediated mechanical response. Acute mechanical stress induced by osmotic swelling or by uniaxial stretching results in a rapi...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2010.12.031

    authors: Sinha B,Köster D,Ruez R,Gonnord P,Bastiani M,Abankwa D,Stan RV,Butler-Browne G,Vedie B,Johannes L,Morone N,Parton RG,Raposo G,Sens P,Lamaze C,Nassoy P

    更新日期:2011-02-04 00:00:00

  • The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless.

    abstract::We have isolated the Drosophila melanogaster homolog (Dint-1) of int-1, a conserved cellular oncogene implicated in viral mammary tumorigenesis in mice. The deduced Dint-1 protein sequence contains 468 amino acids and starts with a hydrophobic leader; it is 54% identical to the int-1 sequence, and all 23 cysteine resi...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(87)90038-9

    authors: Rijsewijk F,Schuermann M,Wagenaar E,Parren P,Weigel D,Nusse R

    更新日期:1987-08-14 00:00:00

  • A pericellular collagenase directs the 3-dimensional development of white adipose tissue.

    abstract::White adipose tissue (WAT) serves as the primary energy depot in the body by storing fat. During development, fat cell precursors (i.e., preadipocytes) undergo a hypertrophic response as they mature into lipid-laden adipocytes. However, the mechanisms that regulate adipocyte size and mass remain undefined. Herein, we ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2006.02.050

    authors: Chun TH,Hotary KB,Sabeh F,Saltiel AR,Allen ED,Weiss SJ

    更新日期:2006-05-05 00:00:00

  • YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism.

    abstract::The role of S. cerevisiae YDJ1 protein (YDJ1p) in polypeptide translocation across membranes has been examined. A conditional ydj1 mutant strain (ydj1-151TS) is defective for import of several polypeptides into mitochondria and alpha factor into the endoplasmic reticulum at 37 degrees C. These defects are suppressed b...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(05)80063-7

    authors: Caplan AJ,Cyr DM,Douglas MG

    更新日期:1992-12-24 00:00:00

  • Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization.

    abstract::The Rho family of GTPases control diverse biological processes, including cell morphology and mitogenesis. We have identified WASP, the protein that is defective in Wiskott-Aldrich syndrome (WAS), as a novel effector for CDC42Hs, but not for the other Rho family members, Rac and Rho. This interaction is dependent on t...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)81050-8

    authors: Symons M,Derry JM,Karlak B,Jiang S,Lemahieu V,Mccormick F,Francke U,Abo A

    更新日期:1996-03-08 00:00:00

  • The transcriptional and epigenomic foundations of ground state pluripotency.

    abstract::Mouse embryonic stem (ES) cells grown in serum exhibit greater heterogeneity in morphology and expression of pluripotency factors than ES cells cultured in defined medium with inhibitors of two kinases (Mek and GSK3), a condition known as "2i" postulated to establish a naive ground state. We show that the transcriptom...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2012.03.026

    authors: Marks H,Kalkan T,Menafra R,Denissov S,Jones K,Hofemeister H,Nichols J,Kranz A,Stewart AF,Smith A,Stunnenberg HG

    更新日期:2012-04-27 00:00:00

  • Enhancement of memory-related long-term facilitation by ApAF, a novel transcription factor that acts downstream from both CREB1 and CREB2.

    abstract::The memory for sensitization of the gill withdrawal reflex in Aplysia is reflected in facilitation of the monosynaptic connection between the sensory and motor neurons of the reflex. The switch from short- to long-term facilitation requires activation of CREB1, derepression of ApCREB2, and induction of ApC/EBP. In sea...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)00163-x

    authors: Bartsch D,Ghirardi M,Casadio A,Giustetto M,Karl KA,Zhu H,Kandel ER

    更新日期:2000-11-10 00:00:00