Abstract:
:Childhood asthma is typically associated with a polarized Th2 response to inhaled allergens and is influenced by genetics. Yang et al. show that the asthma susceptibility gene DENND1B controls cytokine production in Th2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes, providing a molecular basis for how DENND1B contributes to asthma pathogenesis.
journal_name
Celljournal_title
Cellauthors
Godar M,Lambrecht BNdoi
10.1016/j.cell.2015.12.045subject
Has Abstractpub_date
2016-01-14 00:00:00pages
11-13issue
1-2eissn
0092-8674issn
1097-4172pii
S0092-8674(15)01709-2journal_volume
164pub_type
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