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Regulation of CSF1 promoter by the SWI/SNF-like BAF complex.

Abstract：

:The mammalian BAF complex regulates gene expression by modifying chromatin structure. In this report, we identify 80 genes activated and 2 genes repressed by the BAF complex in SW-13 cells. We find that prior binding of NFI/CTF to the NFI/CTF binding site in CSF1 promoter is required for the recruitment of the BAF complex and the BAF-dependent activation of the promoter. Furthermore, the activation of the CSF1 promoter requires Z-DNA-forming sequences that are converted to Z-DNA structure upon activation by the BAF complex. The BAF complex facilitates Z-DNA formation in a nucleosomal template in vitro. We propose a model in which the BAF complex promotes Z-DNA formation which, in turn, stabilizes the open chromatin structure at the CSF1 promoter.

journal_name

Cell

journal_title

Cell

authors

Liu R,Liu H,Chen X,Kirby M,Brown PO,Zhao K

doi

10.1016/s0092-8674(01)00446-9

subject

Has Abstract

pub_date

2001-08-10 00:00:00

pages

309-18

issue

3

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(01)00446-9

journal_volume

106

pub_type

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