Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy.

abstract：:A fusion of the strong cauliflower mosaic virus 35S promoter to the Activator (Ac) transposase (TPASE) gene does not trigger excision of Dissociation (Ds) continuously during tobacco cotyledon development, although once activated, the 35S promoter remains active throughout embryogeny. Epistasis studies where 35S:TPASE...

journal_title：Cell

authors： Scofield SR,English JJ,Jones JD

更新日期：1993-11-05 00:00:00

abstract：:Interaction between CD2 and its counterreceptor, CD58 (LFA-3), on opposing cells optimizes immune recognition, facilitating contacts between helper T lymphocytes and antigen-presenting cells as well as between cytolytic effectors and target cells. Here, we report the crystal structure of the heterophilic adhesion comp...

journal_title：Cell

authors： Wang JH,Smolyar A,Tan K,Liu JH,Kim M,Sun ZY,Wagner G,Reinherz EL

更新日期：1999-06-11 00:00:00

abstract：:Two-component signal transduction systems are the predominant means by which bacteria sense and respond to environmental stimuli. Bacteria often employ tens or hundreds of these paralogous signaling systems, comprised of histidine kinases (HKs) and their cognate response regulators (RRs). Faithful transmission of info...

journal_title：Cell

authors： Skerker JM,Perchuk BS,Siryaporn A,Lubin EA,Ashenberg O,Goulian M,Laub MT

更新日期：2008-06-13 00:00:00

abstract：:Eukaryotic cells have developed mechanisms for regulating the nuclear transport of macromolecules that control various cellular events including movement through defined stages of the cell cycle. In yeast cells, where the nuclear envelope remains intact throughout the cell cycle, these transport regulatory mechanisms ...

journal_title：Cell

authors： Makhnevych T,Lusk CP,Anderson AM,Aitchison JD,Wozniak RW

更新日期：2003-12-26 00:00:00

abstract：:Transcription termination by bacterial RNA polymerase (RNAP) occurs at sequences coding for a GC-rich RNA hairpin followed by a U-rich tract. We used single-molecule techniques to investigate the mechanism by which three representative terminators (his, t500, and tR2) destabilize the elongation complex (EC). For his a...

journal_title：Cell

authors： Larson MH,Greenleaf WJ,Landick R,Block SM

更新日期：2008-03-21 00:00:00

abstract：:We describe genetic and physical characterization of rearrangements of chromosome III which result in changes of cell type in S. cerevisiae. Two types of rearrangements were obtained as rare events which caused a change at the locus controlling cell type, MAT, associated with a recessive lethal mutation, in one case f...

journal_title：Cell

authors： Strathern JN,Newlon CS,Herskowitz I,Hicks JB

更新日期：1979-10-01 00:00:00

abstract：:The replication initiator protein of the plasmid R6K binds to seven contiguous 22 bp direct repeats that form an indispensable part of the three replication origins alpha, beta, and gamma. Binding of the initiator to the direct repeats induced a marked bending of the region of gamma replication origin. Binding of the ...

journal_title：Cell

authors： Mukherjee S,Patel I,Bastia D

更新日期：1985-11-01 00:00:00

abstract：:The scrapie (PrPSc) and cellular (PrPC) prion proteins are encoded by the same gene, and their different properties are thought to arise from posttranslational modifications. We have found a phosphatidylinositol glycolipid on both PrPC and PrP 27-30 (derived from PrPSc by limited proteolysis at the amino terminus). Et...

journal_title：Cell

authors： Stahl N,Borchelt DR,Hsiao K,Prusiner SB

更新日期：1987-10-23 00:00:00

abstract：:During cell division, newly replicated DNA is actively segregated to the daughter cells. In most bacteria, this process involves the DNA-binding protein ParB, which condenses the centromeric regions of sister DNA molecules into kinetochore-like structures that recruit the DNA partition ATPase ParA and the prokaroytic ...

journal_title：Cell

authors： Osorio-Valeriano M,Altegoer F,Steinchen W,Urban S,Liu Y,Bange G,Thanbichler M

更新日期：2019-12-12 00:00:00

abstract：:The synthesis and secretion of plasminogen activator by cultured macrophages can be induced and stimulated by concanavalin A and by phorbol myristate acetate, and inhibited by such agents as glucocorticoids, mitotic inhibitors and compounds affecting cAMP metabolism. By the manipulation of stimulatory and inhibitory i...

journal_title：Cell

authors： Vassalli JD,Hamilton J,Reich E

更新日期：1977-07-01 00:00:00

abstract：:We have used liposomes to deliver DNAase I inside normal Syrian hamster embryo (SHE) cells. We showed the entrance of DNAase I inside the cell by dose-dependent cytotoxicity; and the entrance of DNAase I into the nucleus by the induction of chromosomal aberrations and somatic mutation at the HPRT locus (but not at the...

journal_title：Cell

authors： Zajac-Kaye M,Ts'o PO

更新日期：1984-12-01 00:00:00

abstract：:Genetics and pharmacology can elicit surprisingly different phenotypes despite targeting the same protein. This Essay explores these unexpected differences and their implications for biology and medicine. ...

journal_title：Cell

authors： Knight ZA,Shokat KM

更新日期：2007-02-09 00:00:00

abstract：:Two DNA sequences that reduce mitotic fidelity of chromosome transmission have been identified: MIF1 and MIF2. MIF1 is a unique sequence located on the right arm of chromosome XII that stimulates loss and recombination for both chromosomes V and VII when present in a high copy number plasmid. MIF1 is not essential for...

journal_title：Cell

authors： Meeks-Wagner D,Wood JS,Garvik B,Hartwell LH

更新日期：1986-01-17 00:00:00

abstract：:Prions, self-propagating protein structures that can be transmitted between cells and different organisms, usually consist of ordered protein aggregates. Alberti et al. (2009) now present a systematic approach for the discovery of new prions that expands the spectrum of their biological functions. ...

journal_title：Cell

authors： Fowler DM,Kelly JW

更新日期：2009-04-03 00:00:00

abstract：:Drosophila bicoid mRNA is synthesized in the nurse cells and transported to the oocyte where microtubules and Exuperantia protein mediate localization to the anterior pole. Fluorescent bicoid mRNA injected into the oocyte displays nonpolar microtubule-dependent transport to the closest cortical surface, and the oocyte...

journal_title：Cell

authors： Cha BJ,Koppetsch BS,Theurkauf WE

更新日期：2001-07-13 00:00:00

abstract：:The FoxO transcription factors have been implicated in many processes including tumor suppression and cell death. In this issue, two groups now report on mice that conditionally lack the three predominant FoxO transcription factors. Demonstrate that FoxOs are critical for the long-term maintenance of hematopoietic ste...

journal_title：Cell

authors： Arden KC

更新日期：2007-01-26 00:00:00

abstract：:In the SV40-transformed mouse embryo fibroblast cell line SVT2/S, genomic rearrangements involving the SV40 DNA and flanking host sequences were identified by Southern blot hybridization using viral DNA as probe. No rearrangements of SV40 DNA integrated into nonpermissive mouse cells have been previously described. Th...

journal_title：Cell

authors： Sager R,Anisowicz A,Howell N

更新日期：1981-01-01 00:00:00

abstract：:The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous activation of B cell proliferation and drives the development of GC lymphomas in vivo. HVEM-deficient lymphoma B cells also induce a tumor-supportive microenvi...

journal_title：Cell

authors： Boice M,Salloum D,Mourcin F,Sanghvi V,Amin R,Oricchio E,Jiang M,Mottok A,Denis-Lagache N,Ciriello G,Tam W,Teruya-Feldstein J,de Stanchina E,Chan WC,Malek SN,Ennishi D,Brentjens RJ,Gascoyne RD,Cogné M,Tarte K,Wende

更新日期：2016-10-06 00:00:00

abstract：:Uracil-DNA glycosylase inhibitor (Ugi) is a B. subtilis bacteriophage protein that protects the uracil-containing phage DNA by irreversibly inhibiting the key DNA repair enzyme uracil-DNA glycosylase (UDG). The 1.9 A crystal structure of Ugi complexed to human UDG reveals that the Ugi structure, consisting of a twiste...

journal_title：Cell

authors： Mol CD,Arvai AS,Sanderson RJ,Slupphaug G,Kavli B,Krokan HE,Mosbaugh DW,Tainer JA

更新日期：1995-09-08 00:00:00

abstract：:Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequen...

journal_title：Cell

authors： Volz E,Hill V,McCrone JT,Price A,Jorgensen D,O'Toole Á,Southgate J,Johnson R,Jackson B,Nascimento FF,Rey SM,Nicholls SM,Colquhoun RM,da Silva Filipe A,Shepherd J,Pascall DJ,Shah R,Jesudason N,Li K,Jarrett R,Pacchi

更新日期：2021-01-07 00:00:00

abstract：:A large (approximately 200 kd) subunit of cellular RNA polymerase II (Pol II) and a virus-encoded subunit of rabbit poxvirus (RPV) RNA polymerase (137 kd) react with common monoclonal antibodies. Hybridization studies with viral and cellular DNA clones confirm that the viral and cellular proteins are related. Followin...

journal_title：Cell

authors： Morrison DK,Moyer RW

更新日期：1986-02-28 00:00:00

abstract：:In two companion reports, the TRACERx consortium investigates tumor heterogeneity and evolution in early-stage non-small cell lung cancer. The studies highlight the prognostic value of copy-number heterogeneity assessment in tumor biopsies and circulating tumor DNA detection in plasma and suggest that tracking the evo...

journal_title：Cell

authors： Hsu PP,Shaw AT

更新日期：2017-05-18 00:00:00

abstract：:22q11.2 microdeletions result in specific cognitive deficits and schizophrenia. Analysis of Df(16)A(+/-) mice, which model this microdeletion, revealed abnormalities in the formation of neuronal dendrites and spines, as well as altered brain microRNAs. Here, we show a drastic reduction of miR-185, which resides within...

journal_title：Cell

authors： Xu B,Hsu PK,Stark KL,Karayiorgou M,Gogos JA

更新日期：2013-01-17 00:00:00

abstract：:Neurons need to alter their response to a given stimulus over time in order for the animal to modify its behavior within a changing environment. Chen et al. now demonstrate that neuronal structure and function are altered coordinately by the history of the cell's activity through an unexpected molecular pathway. ...

journal_title：Cell

authors： Della Santina L,Wong RO

更新日期：2012-09-28 00:00:00

abstract：:Activation of the adenylyl cyclase signaling pathway elicits the induction of genes via activators binding to cAMP-responsive elements (CREs). Nuclear factor CRE modulator (CREM) is activated by PKA-mediated phosphorylation on a serine at position 117. We show that Ser-117 is also phosphorylated by the mitogen-activat...

journal_title：Cell

authors： de Groot RP,Ballou LM,Sassone-Corsi P

更新日期：1994-10-07 00:00:00

abstract：:Pseudomonas exotoxin (PE) was used as a probe to study the mechanism by which protein ligands are internalized by mammalian cells. Both biochemical and electron microscopic methods were used to look at the internalization of PE by mouse LM cell fibroblasts. Our data suggest that PE enters cells by receptor-mediated en...

journal_title：Cell

authors： FitzGerald D,Morris RE,Saelinger CB

更新日期：1980-10-01 00:00:00

abstract：:Brefeldin A (BFA) is a fungal metabolite that causes a redistribution of the stacked cisternae of the Golgi complex into the endoplasmic reticulum by inhibiting anterograde transport. We report that BFA also causes membrane tubules derived from the trans-Golgi network (TGN) to fuse with early endosomes. In the presenc...

journal_title：Cell

authors： Wood SA,Park JE,Brown WJ

更新日期：1991-11-01 00:00:00

abstract：:Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and nutrients that may differ from those in which they matured. Imbedded in immune cell physiology are metabolic pathways and metab...

journal_title：Cell

authors： Buck MD,Sowell RT,Kaech SM,Pearce EL

更新日期：2017-05-04 00:00:00

abstract：:NPR1 is an essential regulator of plant systemic acquired resistance (SAR), which confers immunity to a broad-spectrum of pathogens. SAR induction results in accumulation of the signal molecule salicylic acid (SA), which induces defense gene expression via activation of NPR1. We found that in an uninduced state, NPR1 ...

journal_title：Cell

authors： Mou Z,Fan W,Dong X

更新日期：2003-06-27 00:00:00

abstract：:H2S is an endogenous gasotransmitter that plays an important role in physiological conditions. In this issue, Das et al. provide evidence that SIRT1-dependent angiogenesis is augmented by H2S-findings reinforced by Longchamp et al., who demonstrate that H2S-dependent angiogenesis is triggered by amino acid deprivation...

journal_title：Cell

authors： Arumugam TV,Kennedy BK

更新日期：2018-03-22 00:00:00