Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy.

Abstract:

:Cancer cells enter a reversible drug-tolerant persister (DTP) state to evade death from chemotherapy and targeted agents. It is increasingly appreciated that DTPs are important drivers of therapy failure and tumor relapse. We combined cellular barcoding and mathematical modeling in patient-derived colorectal cancer models to identify and characterize DTPs in response to chemotherapy. Barcode analysis revealed no loss of clonal complexity of tumors that entered the DTP state and recurred following treatment cessation. Our data fit a mathematical model where all cancer cells, and not a small subpopulation, possess an equipotent capacity to become DTPs. Mechanistically, we determined that DTPs display remarkable transcriptional and functional similarities to diapause, a reversible state of suspended embryonic development triggered by unfavorable environmental conditions. Our study provides insight into how cancer cells use a developmentally conserved mechanism to drive the DTP state, pointing to novel therapeutic opportunities to target DTPs.

journal_name

Cell

journal_title

Cell

authors

Rehman SK,Haynes J,Collignon E,Brown KR,Wang Y,Nixon AML,Bruce JP,Wintersinger JA,Singh Mer A,Lo EBL,Leung C,Lima-Fernandes E,Pedley NM,Soares F,McGibbon S,He HH,Pollet A,Pugh TJ,Haibe-Kains B,Morris Q,Ramalho-San

doi

10.1016/j.cell.2020.11.018

subject

Has Abstract

pub_date

2021-01-07 00:00:00

pages

226-242.e21

issue

1

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(20)31535-X

journal_volume

184

pub_type

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