Abstract：
:The Ras GTPase links extracellular mitogens to intracellular mechanisms that control cell proliferation. To understand how Ras regulates proliferation in vivo, we activated or inactivated Ras in cell clones in the developing Drosophila wing. Cells lacking Ras were smaller, had reduced growth rates, accumulated in G1, and underwent apoptosis due to cell competition. Conversely, activation of Ras increased cell size and growth rates and promoted G1/S transitions. Ras upregulated the growth driver dMyc, and both Ras and dMyc increased levels of cyclin E posttranscriptionally. We propose that Ras primarily promotes growth and that growth is coupled to G1/S progression via cyclin E. Interestingly, upregulation of growth by Ras did not deregulate G2/M progression or a developmentally regulated cell cycle exit.
journal_name
Celljournal_title
Cellauthors
Prober DA,Edgar BAdoi
10.1016/s0092-8674(00)80679-0subject
Has Abstractpub_date
2000-02-18 00:00:00pages
435-46issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(00)80679-0journal_volume
100pub_type
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