The hows and Ys of genome integrity.

Abstract:

:Much of the Y chromosome consists of large palindromic arrays harboring genes that are critical for spermatogenesis. In this issue, Lange et al. (2009) show that although gene conversion within these arrays maintains their integrity, it also permits rare unequal sister chromatid-exchange events within palindromes that create unstable dicentric chromosomes, resulting in infertility, sex reversal, and Turner syndrome.

journal_name

Cell

journal_title

Cell

authors

Hall HE,Hawley RS

doi

10.1016/j.cell.2009.08.022

subject

Has Abstract

pub_date

2009-09-04 00:00:00

pages

830-2

issue

5

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(09)01039-3

journal_volume

138

pub_type

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