Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7.


:Initiation of tumorigenesis in mouse skin can be accomplished by mutagenesis of the H-ras gene by treatment with chemical carcinogens. A mouse model system has been developed to study the additional genetic events that take place during tumor progression. Skin carcinomas were induced in F1 hybrid mice exhibiting restriction fragment length polymorphisms at multiple chromosomal loci. Analysis of loss of heterozygosity in such tumors showed that imbalance of alleles on mouse chromosome 7, on which the H-ras gene is located, occurs very frequently in skin carcinomas. The chromosomal alterations detected, which included both nondisjunction and mitotic recombination events, were only seen in tumors that have activated ras genes. We conclude that gross chromosomal alterations that elevate the copy number of mutant H-ras and/or lead to loss of normal H-ras are a consistent feature of mouse skin tumor development.






Bremner R,Balmain A




Has Abstract


1990-05-04 00:00:00
















  • Epigenetics of reprogramming to induced pluripotency.

    abstract::Reprogramming to induced pluripotent stem cells (iPSCs) proceeds in a stepwise manner with reprogramming factor binding, transcription, and chromatin states changing during transitions. Evidence is emerging that epigenetic priming events early in the process may be critical for pluripotency induction later. Chromatin ...


    pub_type: 杂志文章,评审


    authors: Papp B,Plath K

    更新日期:2013-03-14 00:00:00

  • RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.

    abstract::Type I interferons (IFNs) are important for antiviral and autoimmune responses. Retinoic acid-induced gene I (RIG-I) and mitochondrial antiviral signaling (MAVS) proteins mediate IFN production in response to cytosolic double-stranded RNA or single-stranded RNA containing 5'-triphosphate (5'-ppp). Cytosolic B form dou...


    pub_type: 杂志文章


    authors: Chiu YH,Macmillan JB,Chen ZJ

    更新日期:2009-08-07 00:00:00

  • The transcription map of mouse mitochondrial DNA.

    abstract::Nine transcripts complementary to mouse L cell mitochondrial DNA have been detected, sized and mapped to restriction fragments using the method of Berk and Sharp (1977). RNA isolated from L cell mitochondria was hybridized to 32P-labeled, cloned L cell mitochondrial DNA restriction fragments in 70% formamide under con...


    pub_type: 杂志文章


    authors: Battey J,Clayton DA

    更新日期:1978-05-01 00:00:00

  • Interspecies Competition Impacts Targeted Manipulation of Human Gut Bacteria by Fiber-Derived Glycans.

    abstract::Development of microbiota-directed foods (MDFs) that selectively increase the abundance of beneficial human gut microbes, and their expressed functions, requires knowledge of both the bioactive components of MDFs and the mechanisms underlying microbe-microbe interactions. Here, gnotobiotic mice were colonized with a d...


    pub_type: 杂志文章


    authors: Patnode ML,Beller ZW,Han ND,Cheng J,Peters SL,Terrapon N,Henrissat B,Le Gall S,Saulnier L,Hayashi DK,Meynier A,Vinoy S,Giannone RJ,Hettich RL,Gordon JI

    更新日期:2019-09-19 00:00:00

  • Architecture and membrane interactions of the EGF receptor.

    abstract::Dimerization-driven activation of the intracellular kinase domains of the epidermal growth factor receptor (EGFR) upon extracellular ligand binding is crucial to cellular pathways regulating proliferation, migration, and differentiation. Inactive EGFR can exist as both monomers and dimers, suggesting that the mechanis...


    pub_type: 杂志文章


    authors: Arkhipov A,Shan Y,Das R,Endres NF,Eastwood MP,Wemmer DE,Kuriyan J,Shaw DE

    更新日期:2013-01-31 00:00:00

  • Regulation of corneal collagenase production: stimulation of serially passaged stromal cells by blood mononuclear cells.

    abstract::After three or more passages, stromal cell outgrowths from explants of normal rabbit corneas and from corneas previously burned with alkali did not produce collagenase until they were stimulated by the addition of rabbit blood-derived mononuclear cells or media conditioned by them. Normal stromal cells required stimul...


    pub_type: 杂志文章


    authors: Newsome DA,Gross J

    更新日期:1979-04-01 00:00:00

  • Repressive Gene Regulation Synchronizes Development with Cellular Metabolism.

    abstract::Metabolic conditions affect the developmental tempo of animals. Developmental gene regulatory networks (GRNs) must therefore synchronize their dynamics with a variable timescale. We find that layered repression of genes couples GRN output with variable metabolism. When repressors of transcription or mRNA and protein s...


    pub_type: 杂志文章


    authors: Cassidy JJ,Bernasek SM,Bakker R,Giri R,Peláez N,Eder B,Bobrowska A,Bagheri N,Nunes Amaral LA,Carthew RW

    更新日期:2019-08-08 00:00:00

  • Pdd1p, a novel chromodomain-containing protein, links heterochromatin assembly and DNA elimination in Tetrahymena.

    abstract::During Tetrahymena conjugation, programmed DNA degradation occurs in two separate nuclei. Thousands of germline-specific deletion elements are removed from the genome of the developing somatic macronucleus, and the old parental macronucleus is degraded by an apoptotic mechanism. An abundant polypeptide, Pdd1p (formerl...


    pub_type: 杂志文章


    authors: Madireddi MT,Coyne RS,Smothers JF,Mickey KM,Yao MC,Allis CD

    更新日期:1996-10-04 00:00:00

  • The role of easter, an apparent serine protease, in organizing the dorsal-ventral pattern of the Drosophila embryo.

    abstract::The maternally transcribed product of the Drosophila easter gene is essential for the establishment of a normal dorsal-ventral pattern in embryos. Loss-of-function mutations in easter result in a dorsalization of the embryonic pattern, while dominant gain-of-function mutations ventralize the embryonic pattern. P eleme...


    pub_type: 杂志文章


    authors: Chasan R,Anderson KV

    更新日期:1989-02-10 00:00:00

  • Gene Expression Changes and Community Turnover Differentially Shape the Global Ocean Metatranscriptome.

    abstract::Ocean microbial communities strongly influence the biogeochemistry, food webs, and climate of our planet. Despite recent advances in understanding their taxonomic and genomic compositions, little is known about how their transcriptomes vary globally. Here, we present a dataset of 187 metatranscriptomes and 370 metagen...


    pub_type: 杂志文章


    authors: Salazar G,Paoli L,Alberti A,Huerta-Cepas J,Ruscheweyh HJ,Cuenca M,Field CM,Coelho LP,Cruaud C,Engelen S,Gregory AC,Labadie K,Marec C,Pelletier E,Royo-Llonch M,Roux S,Sánchez P,Uehara H,Zayed AA,Zeller G,Carmichael

    更新日期:2019-11-14 00:00:00

  • Glucose Metabolism Linked to Antiviral Responses.

    abstract::Viral infection causes the host to activate an antiviral response that, in part, is dependent on mitochondrial antiviral signaling protein (MAVS) to stimulate type I interferons. Zhang et al. (2019) demonstrate that glucose-generated lactate interacts with MAVS to suppress type I interferons. This study links glucose ...


    pub_type: 评论,杂志文章


    authors: Stoolman JS,Chandel NS

    更新日期:2019-06-27 00:00:00

  • Exercise your amyloid.

    abstract::The interplay of genetics and the environment in the etiology of Alzheimer's disease (AD) is not well understood. Now, Lazarov and coworkers show that a simple paradigm of environmental enrichment alleviates amyloid burden and alters disease-associated gene expression changes in a double transgenic mouse model of AD. ...


    pub_type: 评论,杂志文章,评审


    authors: Karsten SL,Geschwind DH

    更新日期:2005-03-11 00:00:00

  • Cellular ras activity and phospholipid metabolism.

    abstract::Cellular ras activity has been neutralized in 3T3 cells by microinjection of a specific anti-ras monoclonal antibody. The injected antibody efficiently inhibited proliferation in cells treated with a phorbol ester and a calcium ionophore, or with prostaglandin F2 alpha. These treatments were designed to imitate the ac...


    pub_type: 杂志文章


    authors: Yu CL,Tsai MH,Stacey DW

    更新日期:1988-01-15 00:00:00

  • Cowpea mosaic virus RNAs have neither m7GpppN ... nor mono-, di- or triphosphates at their 5' ends.

    abstract::32P-labeled cowpea mosaic virus (CPMV) RNAs were analyzed for their 5' termini by three different fingerprinting standard procedures. These analyses showed unequivocally that CPMV RNAs lack a structure like m7GpppN ... at their 5' termini. In addition, neither mono-, di- or triphosphorylated [(p)(p)pN ....] termini we...


    pub_type: 杂志文章


    authors: Klootwijk J,Klein I,Zabel P,van Kammen A

    更新日期:1977-05-01 00:00:00

  • Poly(A) polymerase and a dissociable polyadenylation stimulatory factor encoded by vaccinia virus.

    abstract::mRNA made in eukaryotic cells typically has a 3' poly(A) tail that is added posttranscriptionally. To investigate mechanisms by which 3' poly(A) is formed, we identified the genes for the two vaccina virus-encoded polypeptides, VP55 and VP39. Primer-dependent polyadenylation activity was associated exclusively with pu...


    pub_type: 杂志文章


    authors: Gershon PD,Ahn BY,Garfield M,Moss B

    更新日期:1991-09-20 00:00:00

  • A study of foldback DNA.

    abstract::Nuclear DNA from eucaryotes contains a significant fraction which forms duplexes very rapidly and also independently of the DNA concentration. This fraction can be isolated by adsorption to hydroxylapatite and has been called foldback DNA (Britten and Smith, 1970). Here we extend previous studies to show that the fold...


    pub_type: 杂志文章


    authors: Perlman S,Phillips C,Bishop JO

    更新日期:1976-05-01 00:00:00

  • A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro.

    abstract::Erythroid Krüppel-like factor (EKLF) is necessary for stage-specific expression of the human beta-globin gene. We show that EKLF requires a SWI/SNF-related chromatin remodeling complex, EKLF coactivator-remodeling complex 1 (E-RC1), to generate a DNase I hypersensitive, transcriptionally active beta-globin promoter on...


    pub_type: 杂志文章


    authors: Armstrong JA,Bieker JJ,Emerson BM

    更新日期:1998-10-02 00:00:00

  • SPA1: a gene important for chromosome segregation and other mitotic functions in S. cerevisiae.

    abstract::Human autoantibodies that recognize the spindle poles of mammals, plants, and insects were found to recognize two antigens in yeast. One of these proteins, called SPA1 (for Spindle Pole Antigen), is antigenically related to the spindle poles of a diverse set of organisms. The gene encoding SPA1 was cloned by immunoscr...


    pub_type: 杂志文章


    authors: Snyder M,Davis RW

    更新日期:1988-09-09 00:00:00

  • Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.

    abstract::Metazoan evolution involves increasing protein domain complexity, but how this relates to control of biological decisions remains uncertain. The Ras guanine nucleotide exchange factor (RasGEF) Sos1 and its adaptor Grb2 are multidomain proteins that couple fibroblast growth factor (FGF) signaling to activation of the R...


    pub_type: 杂志文章


    authors: Findlay GM,Smith MJ,Lanner F,Hsiung MS,Gish GD,Petsalaki E,Cockburn K,Kaneko T,Huang H,Bagshaw RD,Ketela T,Tucholska M,Taylor L,Bowtell DD,Moffat J,Ikura M,Li SS,Sidhu SS,Rossant J,Pawson T

    更新日期:2013-02-28 00:00:00

  • Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells.

    abstract::In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and reassemble into the newly forming nuclei. However, the fate of nuclear pores in postmitotic cells is unknown. Here, we show that NPCs, unlike other nuclear structures, do not turn over in differentiated cells. While a subset of NPC compone...


    pub_type: 杂志文章


    authors: D'Angelo MA,Raices M,Panowski SH,Hetzer MW

    更新日期:2009-01-23 00:00:00

  • Polo delivers a PICH to the kinetochore.

    abstract::In this issue, Baumann et al. (2007) identify a helicase PICH that localizes to "threads" that remain connected between sister kinetochores after they have separated in anaphase. These threads are thought to be catenated centromeric DNA. PICH contributes to the mitotic checkpoint by recruiting Mad2 to kinetochores and...


    pub_type: 评论,杂志文章


    authors: Yen TJ

    更新日期:2007-01-12 00:00:00

  • Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3.

    abstract::The Bcl-2 family proteins are key regulators of apoptosis in human diseases and cancers. Though known to block apoptosis, Bcl-2 promotes cell death through an undefined mechanism. Here, we show that Bcl-2 interacts with orphan nuclear receptor Nur77 (also known as TR3), which is required for cancer cell apoptosis indu...


    pub_type: 杂志文章


    authors: Lin B,Kolluri SK,Lin F,Liu W,Han YH,Cao X,Dawson MI,Reed JC,Zhang XK

    更新日期:2004-02-20 00:00:00

  • The bacterial toxin RelE displays codon-specific cleavage of mRNAs in the ribosomal A site.

    abstract::The Escherichia coli relBE operon encodes a toxin-antitoxin pair, RelE-RelB. RelB can reverse inhibition of protein synthesis by RelE in vivo. We have found that although RelE does not degrade free RNA, it cleaves mRNA in the ribosomal A site with high codon specificity. Among stop codons UAG is cleaved with fast, UAA...


    pub_type: 杂志文章


    authors: Pedersen K,Zavialov AV,Pavlov MY,Elf J,Gerdes K,Ehrenberg M

    更新日期:2003-01-10 00:00:00

  • SGV1 encodes a CDC28/cdc2-related kinase required for a G alpha subunit-mediated adaptive response to pheromone in S. cerevisiae.

    abstract::The GPA1 gene of S. cerevisiae encodes a G alpha subunit that plays a positive role in the transduction of signals stimulating recovery from pheromone-induced cell cycle arrest. The GPA1Val50 mutation, in which Gly-50 is replaced by valine, causes hyperadaptation to pheromone. However, GPA1Val50 cells do not recover f...


    pub_type: 杂志文章


    authors: Irie K,Nomoto S,Miyajima I,Matsumoto K

    更新日期:1991-05-31 00:00:00

  • Uniformity from Diversity: Vast-Range Light Sensing in a Single Neuron Type.

    abstract::The brightness of our visual environment varies tremendously from day to night. In this issue of Cell, Milner and Do describe how the population of retinal neurons responsible for entrainment of the brain's circadian clock cooperate to encode irradiance across a wide range of ambient-light intensities. ...


    pub_type: 评论,杂志文章


    authors: Varadarajan SG,Huberman AD

    更新日期:2017-11-02 00:00:00

  • Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation.

    abstract::Synthesis of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], a signaling phospholipid, is primarily carried out by phosphatidylinositol 4-phosphate 5-kinase [PI(4)P5K], which has been reported to be regulated by RhoA and Rac1. Unexpectedly, we find that the GTPgammaS-dependent activator of PI(4)P5Kalpha is the smal...


    pub_type: 杂志文章


    authors: Honda A,Nogami M,Yokozeki T,Yamazaki M,Nakamura H,Watanabe H,Kawamoto K,Nakayama K,Morris AJ,Frohman MA,Kanaho Y

    更新日期:1999-11-24 00:00:00

  • Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.

    abstract::The HIV auxiliary protein Vpr potently blocks the cell cycle at the G2/M transition. Here, we show that G2/M arrest results from untimely activation of the structure-specific endonuclease (SSE) regulator SLX4 complex (SLX4com) by Vpr, a process that requires VPRBP-DDB1-CUL4 E3-ligase complex. Direct interaction of Vpr...


    pub_type: 杂志文章


    authors: Laguette N,Brégnard C,Hue P,Basbous J,Yatim A,Larroque M,Kirchhoff F,Constantinou A,Sobhian B,Benkirane M

    更新日期:2014-01-16 00:00:00

  • Powered by gas--a ligand for a fruit fly nuclear receptor.

    abstract::The difficulty in identifying ligands for nuclear hormone receptors remains an obstacle to understanding their function. For example, in the fruit fly Drosophila melanogaster, only one of its nuclear receptors has a known ligand. In this issue of Cell, report that the fruit fly E75 nuclear receptor contains heme in it...


    pub_type: 评论,杂志文章


    authors: Thummel CS

    更新日期:2005-07-29 00:00:00

  • Factor-independent termination of transcription in a stretch of deoxyadenosine residues in the template DNA.

    abstract::The primer transcript of plasmid ColE1 extends beyond the replication origin in either of two different modes. It does or does not form a hybrid with the template DNA. When a stretch of 20 deoxyadenosine residues is inserted into the template strand downstream of the origin, more than 90% of hybridized transcripts and...


    pub_type: 杂志文章


    authors: Tomizawa J,Masukata H

    更新日期:1987-11-20 00:00:00

  • The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1.

    abstract::The anaphase-promoting complex/cyclosome (APC/C) inhibitor Emi1 controls progression to S phase and mitosis by stabilizing key APC/C ubiquitination substrates, including cyclin A. Examining Emi1 binding proteins, we identified the Evi5 oncogene as a regulator of Emi1 accumulation. Evi5 antagonizes SCF(betaTrCP)-depend...


    pub_type: 杂志文章


    authors: Eldridge AG,Loktev AV,Hansen DV,Verschuren EW,Reimann JD,Jackson PK

    更新日期:2006-01-27 00:00:00