Abstract：
:Meyer et al. find that subjects lacking the AIRE gene, critical for self-tolerance in T lymphocytes, show a broad range of autoantibody specificities, which can have extremely high affinities. The data also suggest that some of these autoantibodies can, surprisingly, prevent some types of autoimmunity, particularly type I diabetes.
journal_name
Celljournal_title
Cellauthors
Davis MMdoi
10.1016/j.cell.2016.07.018subject
Has Abstractpub_date
2016-07-28 00:00:00pages
530-531issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(16)30925-4journal_volume
166pub_type
评论,杂志文章相关文献
CELL文献大全abstract：:The stomata of plants regulate gas exchange and water transpiration in response to changing environmental conditions. New work reveals that stomata also have an important role in host defense. In this issue of Cell, Melotto et al. (2006) show that stomata close upon detection of potential microbial pathogens to preven...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2006.08.020
更新日期：2006-09-08 00:00:00
abstract：:Cortical layer 1 (L1) interneurons have been proposed as a hub for attentional modulation of underlying cortex, but the transformations that this circuit implements are not known. We combined genetically targeted voltage imaging with optogenetic activation and silencing to study the mechanisms underlying sensory proce...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.01.001
更新日期：2020-02-06 00:00:00
abstract：:The synthesis and secretion of plasminogen activator by cultured macrophages can be induced and stimulated by concanavalin A and by phorbol myristate acetate, and inhibited by such agents as glucocorticoids, mitotic inhibitors and compounds affecting cAMP metabolism. By the manipulation of stimulatory and inhibitory i...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(77)90086-1
更新日期：1977-07-01 00:00:00
abstract：:During C. elegans embryogenesis an 8-cell stage blastomere, called MS, undergoes a reproducible cleavage pattern, producing pharyngeal cells, body wall muscles, and cell deaths. We show here that maternal-effect mutations in the pie-1 and mex-1 genes cause additional 8-cell stage blastomeres to adopt a fate very simil...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90542-k
更新日期：1992-07-10 00:00:00
abstract：:During adaptive angiogenesis, a key process in the etiology and treatment of cancer and obesity, the vasculature changes to meet the metabolic needs of its target tissues. Although the cues governing vascular remodeling are not fully understood, target-derived signals are generally believed to underlie this process. H...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.12.008
更新日期：2014-01-16 00:00:00
abstract：:Using cryo-electron microscopy, we have solved the structure of an icosidodecahedral COPII coat involved in cargo export from the endoplasmic reticulum (ER) coassembled from purified cargo adaptor Sec23-24 and Sec13-31 lattice-forming complexes. The coat structure shows a tetrameric assembly of the Sec23-24 adaptor la...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.06.024
更新日期：2008-08-08 00:00:00
abstract：:We have isolated spontaneous temperature-resistant revertants of a temperature-sensitive mutation (rpoD800) in the sigma subunit of E. coli K12 RNA polymerase. These revertants still contained the rpoD800 allele. They were mucoid, and sensitive to ultraviolet light and the radiomimetic agent nitrofurantoin, which are ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90505-6
更新日期：1983-01-01 00:00:00
abstract：:Lambda integrative recombination depends on supercoiling of the phage attachment site, attP. Using dimethylsulfate protection and indirect end-labeling, the interaction of the recombination proteins Int and IHF with supercoiled and linear attP has been studied. Supercoiling enhances the binding of Int to attP, but not...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90700-2
更新日期：1986-09-26 00:00:00
abstract：:Neurospora mitochondrial tyrosyl-tRNA synthetase (mt TyrRS), which is encoded by nuclear gene cyt-18, functions in splicing group I introns. Analysis of intragenic partial revertants of the cyt-18-2 mutant and in vitro mutants of the cyt-18 protein expressed in E. coli showed that splicing activity of the cyt-18 prote...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90119-y
更新日期：1990-08-24 00:00:00
abstract：:Transcriptional analysis of SV40 late promoter mutants indicates that the DNA sequence 5'-GGTACCTAACC-3' (map positions 294-304) is important in the control of SV40 late RNA expression. C to T base substitutions at map positions 298, 299 and 304 increased initiation of late RNA synthesis at map position 325 five to te...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90318-x
更新日期：1982-12-01 00:00:00
abstract：:Release of CHO-K1 cells from plateau or stationary phase and reentry into the cell cycle is specifically and reversibly blocked at two distinct sites by the anticalmodulin drug W13. The first block occurs early during release while the cells are still at G0/G1, whereas the second occurs later in reentry during early S...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(84)90075-8
更新日期：1984-01-01 00:00:00
abstract：:We have characterized a nondifferentiating mouse muscle cell line, NFB, that represses the activity of the helix-loop-helix (HLH) family of myogenic regulators, yet expresses sarcomeric actins. The NFB MyoD gene is silent, but can be activated upon transfection of a long terminal region-controlled chicken MyoD cDNA, r...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90014-6
更新日期：1990-08-10 00:00:00
abstract：:AMPA receptors mediate fast excitatory neurotransmission in the mammalian brain and transduce the binding of presynaptically released glutamate to the opening of a transmembrane cation channel. Within the postsynaptic density, however, AMPA receptors coassemble with transmembrane AMPA receptor regulatory proteins (TAR...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.07.045
更新日期：2017-09-07 00:00:00
abstract：:The lack of in vitro prostate cancer models that recapitulate the diversity of human prostate cancer has hampered progress in understanding disease pathogenesis and therapy response. Using a 3D organoid system, we report success in long-term culture of prostate cancer from biopsy specimens and circulating tumor cells....
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.08.016
更新日期：2014-09-25 00:00:00
abstract：:We have developed an in vitro system utilizing yeast cell-free extracts to catalyze recombination events between homologous plasmids containing different mutant alleles of the Tet or ARG4 genes. The reaction increased the frequency of Tcr or Arg+ transformants (recombinants) from 2 X 10(-6) to 1-3 X 10(-3). Linearizin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90113-7
更新日期：1983-12-01 00:00:00
abstract：:The chronic autoimmune diseases include multiple complex genetic disorders. Recently, genome-wide association studies (GWAS) have identified a large number of major loci, with many associations shared between various autoimmune diseases. These associations highlight key roles for lymphocyte activation and prioritize s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.03.003
更新日期：2010-03-19 00:00:00
abstract：:The lateral hypothalamic (LH) projection to the ventral tegmental area (VTA) has been linked to reward processing, but the computations within the LH-VTA loop that give rise to specific aspects of behavior have been difficult to isolate. We show that LH-VTA neurons encode the learned action of seeking a reward, indepe...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.01.003
更新日期：2015-01-29 00:00:00
abstract：:We have generated mice carrying a germline mutation in the tyrosine kinase catalytic domain of the trkB gene. This mutation eliminates expression of gp145trkB, a protein-tyrosine kinase that serves as the signaling receptor for two members of the nerve growth factor family of neurotrophins, brain-derived neurotrophic ...
journal_title：Cell
pub_type： 杂志文章
doi：
更新日期：1993-10-08 00:00:00
abstract：:Hair cells are mechanosensors for the perception of sound, acceleration, and fluid motion. Mechanotransduction channels in hair cells are gated by tip links, which connect the stereocilia of a hair cell in the direction of their mechanical sensitivity. The molecular constituents of the mechanotransduction channels of ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.10.041
更新日期：2012-12-07 00:00:00
abstract：:To relate different forms of synaptic plasticity to the formation and maintenance of place cells in the hippocampus, we have recorded place cells in freely behaving, transgenic mice that express a mutated Ca2+-independent form of CaM Kinase II. These mice have normal long-term potentiation (LTP) at 100 Hz, but they la...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81829-2
更新日期：1996-12-27 00:00:00
abstract：:In this issue of Cell, two articles show that tumor-specific changes in HLA-mediated antigen presentation affect tumor immunogenicity and may play a role in shaping cancer cell survival. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2017.11.012
更新日期：2017-11-30 00:00:00
abstract：:Rho and rac, two members of the ras-related superfamily of small GTPases, regulate the polymerization of actin to produce stress fibers and lamellipodia, respectively. We report here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell peripher...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90370-4
更新日期：1995-04-07 00:00:00
abstract：:Short DNA chains, isolated from in vitro pulse-labeled replicating polyoma DNA, exhibit some degree of self-complementarity (28% resistance to S1 nuclease after self-annealing to plateau levels). This level of self-annealing is not increased if short DNA chains present as free single-stranded DNA after extraction are ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(75)90028-8
更新日期：1975-06-01 00:00:00
abstract：:torso encodes a receptor tyrosine kinase (torso) required for anterior and posterior terminal development of the Drosophila embryo. Injecting eggs with in vitro synthesized torso mRNAs revealed that torso activation is governed by an extracellular molecule, presumably the torso ligand, produced at terminal regions of ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90394-r
更新日期：1992-12-11 00:00:00
abstract：:Germinal centers develop in peripheral lymphatic tissue during the primary immune response and may play a crucial role in affinity maturation. We have compared the diversification of the antigen-specific repertoire of B cells, both from within and from outside the germinal centers, during the murine response to 2-phen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90289-b
更新日期：1991-12-20 00:00:00
abstract：:Chromosomal translocations between antigen receptor loci and oncogenes are a hallmark of lymphoid cancers. Several new studies now reveal that programmed DNA breaks created during assembly of antigen receptor genes can be channeled into an alternative DNA end-joining pathway that is implicated in the chromosomal trans...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.10.005
更新日期：2007-10-19 00:00:00
abstract：:We report the identification of SED1, a protein required for mouse sperm binding to the egg zona pellucida. SED1 is homologous to a small group of secreted cell-matrix adhesive proteins that contain Notch-like EGF repeats and discoidin/F5/8 type C domains. SED1 is expressed in spermatogenic cells and is secreted by th...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00643-3
更新日期：2003-08-22 00:00:00
abstract：:Organisms maintain the correct balance of intracellular metals primarily through metal-sensing proteins that control transport and storage of the target ion(s). Here, we reveal the basis of metal sensing and genetic control by a metalloregulatory RNA. Our data demonstrate that a previously uncharacterized orphan ribos...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.06.051
更新日期：2007-09-07 00:00:00
abstract：:The brain produces two brain-derived neurotrophic factor (BDNF) transcripts, with either short or long 3' untranslated regions (3' UTRs). The physiological significance of the two forms of mRNAs encoding the same protein is unknown. Here, we show that the short and long 3' UTR BDNF mRNAs are involved in different cell...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.05.045
更新日期：2008-07-11 00:00:00
abstract：:The precursor of the 55K adenovirus terminal protein is an 87K protein that is covalently linked to viral DNA. This protein is likely to be identical to the 80,000 dalton protein described by Challberg et al. (1980). The mRNA for the 87K terminal protein precursor, like that for the E2-72K DNA binding protein, is dete...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90145-8
更新日期：1981-02-01 00:00:00
