Muscle fiber pattern is independent of cell lineage in postnatal rodent development.

abstract：:Phage G1 gp67 is a 23 kDa protein that binds to the Staphylococcus aureus (Sau) RNA polymerase (RNAP) σ(A) subunit and blocks cell growth by inhibiting transcription. We show that gp67 has little to no effect on transcription from most promoters but is a potent inhibitor of ribosomal RNA transcription. A 2.0-Å-resolut...

journal_title：Cell

authors： Osmundson J,Montero-Diez C,Westblade LF,Hochschild A,Darst SA

更新日期：2012-11-21 00:00:00

abstract：:Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken. Among identified targets was BCL2, whose germline deletion produces melanocyte loss and w...

journal_title：Cell

authors： McGill GG,Horstmann M,Widlund HR,Du J,Motyckova G,Nishimura EK,Lin YL,Ramaswamy S,Avery W,Ding HF,Jordan SA,Jackson IJ,Korsmeyer SJ,Golub TR,Fisher DE

更新日期：2002-06-14 00:00:00

abstract：:Discs large (DLG) mediates the clustering of synaptic molecules. Here we demonstrate that synaptic localization of DLG itself is regulated by CaMKII. We show that DLG and CaMKII colocalize at synapses and exist in the same protein complex. Constitutively activated CaMKII phenocopied structural abnormalities of dlg mut...

journal_title：Cell

authors： Koh YH,Popova E,Thomas U,Griffith LC,Budnik V

更新日期：1999-08-06 00:00:00

abstract：:A key feature of plants (as opposed to animals) is their ability to establish new organs not only during embryogenesis, but also throughout their development. A master regulator of organ initiation in plants is the phytohormone auxin. Auxin acts locally as a morphogen and is directionally transported from cell to cell...

journal_title：Cell

authors： Jaillais Y,Santambrogio M,Rozier F,Fobis-Loisy I,Miège C,Gaude T

更新日期：2007-09-21 00:00:00

abstract：:We used the interaction trap, a yeast genetic selection for interacting proteins, to isolate human cyclin-dependent kinase interactor 1 (Cdi1). In yeast, Cdi1 interacts with cyclin-dependent kinases, including human Cdc2, Cdk2, and Cdk3, but not with Ckd4. In HeLa cells, Cdi1 is expressed at the G1 to S transition, an...

journal_title：Cell

authors： Gyuris J,Golemis E,Chertkov H,Brent R

更新日期：1993-11-19 00:00:00

abstract：:Much of our understanding of chromosome segregation is based on cell culture systems. Here, we examine the importance of the tissue environment for chromosome segregation by comparing chromosome segregation fidelity across several primary cell types in native and nonnative contexts. We discover that epithelial cells h...

journal_title：Cell

authors： Knouse KA,Lopez KE,Bachofner M,Amon A

更新日期：2018-09-20 00:00:00

abstract：:Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable methods to identify and interrogate pathways involved in pancreatic tumorigenesis are urgently needed. We established organoid models from normal and neoplastic murine and human pancreas tiss...

journal_title：Cell

authors： Boj SF,Hwang CI,Baker LA,Chio II,Engle DD,Corbo V,Jager M,Ponz-Sarvise M,Tiriac H,Spector MS,Gracanin A,Oni T,Yu KH,van Boxtel R,Huch M,Rivera KD,Wilson JP,Feigin ME,Öhlund D,Handly-Santana A,Ardito-Abraham CM,L

更新日期：2015-01-15 00:00:00

abstract：:We have sequenced HFL1 from D. melanogaster, the only cloned hobo element shown to have transposase activity. The 2959 bp HFL1 sequence predicts a 2.0 kb open reading frame (ORF1) with substantial amino acid similarity to the transposases of Activator (Ac) from maize (Zea mays) and Tam3 from snapdragon (Antirrhinum ma...

journal_title：Cell

authors： Calvi BR,Hong TJ,Findley SD,Gelbart WM

更新日期：1991-08-09 00:00:00

abstract：:The mammalian BAF complex regulates gene expression by modifying chromatin structure. In this report, we identify 80 genes activated and 2 genes repressed by the BAF complex in SW-13 cells. We find that prior binding of NFI/CTF to the NFI/CTF binding site in CSF1 promoter is required for the recruitment of the BAF com...

journal_title：Cell

authors： Liu R,Liu H,Chen X,Kirby M,Brown PO,Zhao K

更新日期：2001-08-10 00:00:00

abstract：:The effects of beta-estradiol (estrogen; a minor component of yeast cells) on S. cerevisiae cells in the G0 and G1 phases were examined. Results showed that estrogen stimulated the recovery of growth from G0 arrest induced by nutrient limitation or ts mutation of cdc35 (adenylate cyclase) in the early G1 phase, and in...

journal_title：Cell

authors： Tanaka S,Hasegawa S,Hishinuma F,Kurata S

更新日期：1989-05-19 00:00:00

abstract：:Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (CLR + RAMP1) offer considerable improvements over existing drugs in migraine prophylaxis and are the first designed to act on the trigeminal pain system. Erenumab is approved by the FDA and EMA and has reached the market since May 20...

journal_title：Cell

authors： Edvinsson L

更新日期：2018-12-13 00:00:00

abstract：:We have cloned and characterized the rat telomerase protein component 1 gene (TLP1), which is related to the gene for Tetrahymena p80. The cDNA encodes a 2629 amino acid sequence and produces the TLP1 proteins p240 and p230. The anti-TLP1 antibody specifically immunoprecipitated the telomerase activity. Moreover, p240...

journal_title：Cell

authors： Nakayama J,Saito M,Nakamura H,Matsuura A,Ishikawa F

更新日期：1997-03-21 00:00:00

abstract：:Antigen presenting cells (macrophages and dendritic cells) express pattern recognition molecules that are thought to recognize foreign ligands during early phases of the immune response. The best known of these are probably the Toll-like receptors, but a number of other receptors are also involved. Several of these re...

journal_title：Cell

authors： Gordon S

更新日期：2002-12-27 00:00:00

abstract：:When treated with the synthetic glucocorticoid dexamethasone, HT1080 human fibrosarcoma cells show changes in morphology, adhesion, and the extracellular matrix. Dexamethasone treatment results in a tenfold increase in the rate of fibronectin biosynthesis in HT1080 cells and a twofold increase in untransformed, normal...

journal_title：Cell

authors： Oliver N,Newby RF,Furcht LT,Bourgeois S

更新日期：1983-05-01 00:00:00

abstract：:The inhibitor of apoptosis (IAP) proteins suppress cell death by inhibiting the catalytic activity of caspases. Here we present the crystal structure of caspase-7 in complex with a potent inhibitory fragment from XIAP at 2.45 A resolution. An 18-residue XIAP peptide binds the catalytic groove of caspase-7, making exte...

journal_title：Cell

authors： Chai J,Shiozaki E,Srinivasula SM,Wu Q,Datta P,Alnemri ES,Shi Y

更新日期：2001-03-09 00:00:00

abstract：:Hunger and thirst have distinct goals but control similar ingestive behaviors, and little is known about neural processes that are shared between these behavioral states. We identify glutamatergic neurons in the peri-locus coeruleus (periLCVGLUT2 neurons) as a polysynaptic convergence node from separate energy-sensiti...

journal_title：Cell

authors： Gong R,Xu S,Hermundstad A,Yu Y,Sternson SM

更新日期：2020-09-17 00:00:00

abstract：:CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic elements. To broadly enable the application of Cas9 in vivo, we established a Cre-dependent Cas9 knockin mouse. We demonstrated in vivo as well as ex vivo genome editing using adeno-associated virus (AAV)-, lentivirus-, or parti...

journal_title：Cell

authors： Platt RJ,Chen S,Zhou Y,Yim MJ,Swiech L,Kempton HR,Dahlman JE,Parnas O,Eisenhaure TM,Jovanovic M,Graham DB,Jhunjhunwala S,Heidenreich M,Xavier RJ,Langer R,Anderson DG,Hacohen N,Regev A,Feng G,Sharp PA,Zhang F

更新日期：2014-10-09 00:00:00

abstract：:We performed a comprehensive assessment of rare inherited variation in autism spectrum disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD risk, including 24 passing genome-wide Bonferroni correction and 16 new ASD risk gen...

journal_title：Cell

authors： Ruzzo EK,Pérez-Cano L,Jung JY,Wang LK,Kashef-Haghighi D,Hartl C,Singh C,Xu J,Hoekstra JN,Leventhal O,Leppä VM,Gandal MJ,Paskov K,Stockham N,Polioudakis D,Lowe JK,Prober DA,Geschwind DH,Wall DP

更新日期：2019-08-08 00:00:00

abstract：:Neurons are frequently classified into distinct types on the basis of structural, physiological, or genetic attributes. To better constrain the definition of neuronal cell types, we characterized the transcriptomes and intrinsic physiological properties of over 4,200 mouse visual cortical GABAergic interneurons and re...

journal_title：Cell

authors： Gouwens NW,Sorensen SA,Baftizadeh F,Budzillo A,Lee BR,Jarsky T,Alfiler L,Baker K,Barkan E,Berry K,Bertagnolli D,Bickley K,Bomben J,Braun T,Brouner K,Casper T,Crichton K,Daigle TL,Dalley R,de Frates RA,Dee N,Dest

更新日期：2020-11-12 00:00:00

abstract：:The origin recognition complex (ORC) is required to initiate eukaryotic DNA replication and also engages in transcriptional silencing in S. cerevisiae. We observed a striking preferential but not exclusive association of Drosophila ORC2 with heterochromatin on interphase and mitotic chromosomes. HP1, a heterochromatin...

journal_title：Cell

authors： Pak DT,Pflumm M,Chesnokov I,Huang DW,Kellum R,Marr J,Romanowski P,Botchan MR

更新日期：1997-10-31 00:00:00

abstract：:Strains of Saccharomyces that carry the nib allele of a nuclear gene exhibit a "nibbled" colony morphology if they also harbor the plasmid 2 mu DNA. I have found that the expression of the nibbled phenotype is correlated with the presence of a subpopulation of abnormally large cells that give rise to mortal clones. La...

journal_title：Cell

authors： Holm C

更新日期：1982-06-01 00:00:00

abstract：:A glycoprotein of molecular weight 130,000 (gP130) has been precipitated from the cytoplasm of GR-strain mouse mammary tumor (GR-MMT) cells by a rabbit antiserum (anti-MMTV) to GR-strain mouse mammary tumor virus (GR-MMTV). This protein was not precipitated by antisera specific for detergent-disrupted C3H-strain MMTV ...

journal_title：Cell

authors： Anderson SJ,Naso RB

更新日期：1980-10-01 00:00:00

abstract：:The proportion of BFU-E normally engaged in DNA synthesis is low in adult B6 (C57BL/6) mice of genotype Fv2rr (resistant to Friend erythroleukemia virus), as shown by 3H-thymidine or hydroxyurea "cell suicide" experiments in vivo and vitro. When bone marrow cells from these mice were subjected to a single wash in alph...

journal_title：Cell

authors： Axelrad AA,Croizat H,Eskinazi D

更新日期：1981-10-01 00:00:00

abstract：:The 90S pre-ribosome is an early biogenesis intermediate formed during co-transcriptional ribosome formation, composed of ∼70 assembly factors and several small nucleolar RNAs (snoRNAs) that associate with nascent pre-rRNA. We report the cryo-EM structure of the Chaetomium thermophilum 90S pre-ribosome, revealing how ...

journal_title：Cell

authors： Kornprobst M,Turk M,Kellner N,Cheng J,Flemming D,Koš-Braun I,Koš M,Thoms M,Berninghausen O,Beckmann R,Hurt E

更新日期：2016-07-14 00:00:00

abstract：:Bacteria are known to communicate primarily via secreted extracellular factors. Here we identify a previously uncharacterized type of bacterial communication mediated by nanotubes that bridge neighboring cells. Using Bacillus subtilis as a model organism, we visualized transfer of cytoplasmic fluorescent molecules bet...

journal_title：Cell

authors： Dubey GP,Ben-Yehuda S

更新日期：2011-02-18 00:00:00

abstract：:At the replication origin of ColE1 plasmid, a persistent hybrid is formed between the primer precursor (RNA II) and its template DNA. The wild-type sequence in the region 13 to 20 bp upstream (-20 region) of the origin is required to form this persistent hybrid. While the template strand for transcription of this regi...

journal_title：Cell

authors： Masukata H,Tomizawa J

更新日期：1990-07-27 00:00:00

abstract：:Angiogenesis is an important event for embryonic organogenesis as well as for tissue repair in the adult. Here, we show that hematopoietic stem cells (HSCs) play important roles for angiogenesis during embryogenesis. To investigate the role of HSCs in endothelial cell (EC) development, we analyzed AML1-deficient embry...

journal_title：Cell

authors： Takakura N,Watanabe T,Suenobu S,Yamada Y,Noda T,Ito Y,Satake M,Suda T

更新日期：2000-07-21 00:00:00

abstract：:We have isolated and characterized a set of overlapping cDNA clones that encode the human centromere autoantigen centromere protein C (CENP-C). The identity of these clones has been established using several criteria. First, they were shown to encode a polypeptide that migrates at the expected position for CENP-C on S...

journal_title：Cell

authors： Saitoh H,Tomkiel J,Cooke CA,Ratrie H 3rd,Maurer M,Rothfield NF,Earnshaw WC

更新日期：1992-07-10 00:00:00

abstract：:A plasmid, pHR402, containing SV40 sequences that include a truncated early region bearing an intact t-coding sequence and a functionally intact late region, was introduced into thymidine kinase deficient (tk-) mouse L cells by cotransformation with a cloned tk gene. tk+ cotransformants synthesized SV40 t but not T an...

journal_title：Cell

authors： Rubin H,Figge J,Bladon MT,Chen LB,Ellman M,Bikel I,Farrell M,Livingston DM

更新日期：1982-09-01 00:00:00

abstract：:CFTR, the protein associated with cystic fibrosis, is phosphorylated on serine residues in response to cAMP agonists. Serines 660, 737, 795, and 813 were identified as in vivo targets for phosphorylation by protein kinase A. The SPQ fluorescence assay revealed that mutagenesis of any one of these sites did not affect ...

journal_title：Cell

authors： Cheng SH,Rich DP,Marshall J,Gregory RJ,Welsh MJ,Smith AE

更新日期：1991-09-06 00:00:00