Abstract:
:Neurons typically settle at positions that match the location of their synaptic targets, creating topographic maps. In the spinal cord, the organization of motor neurons into discrete clusters is linked to the location of their muscle targets, establishing a topographic map of punctate design. To define the significance of motor pool organization for neuromuscular map formation, we assessed the role of cadherin-catenin signaling in motor neuron positioning and limb muscle innervation. We find that joint inactivation of β- and γ-catenin scrambles motor neuron settling position in the spinal cord but fails to erode the predictive link between motor neuron transcriptional identity and muscle target. Inactivation of N-cadherin perturbs pool positioning in similar ways, albeit with reduced penetrance. These findings reveal that cadherin-catenin signaling directs motor pool patterning and imposes topographic order on an underlying identity-based neural map.
journal_name
Celljournal_title
Cellauthors
Demireva EY,Shapiro LS,Jessell TM,Zampieri Ndoi
10.1016/j.cell.2011.09.037subject
Has Abstractpub_date
2011-10-28 00:00:00pages
641-52issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(11)01148-2journal_volume
147pub_type
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