Abstract：
:To mechanistically characterize the microevolutionary processes active in altering transcription factor (TF) binding among closely related mammals, we compared the genome-wide binding of three tissue-specific TFs that control liver gene expression in six rodents. Despite an overall fast turnover of TF binding locations between species, we identified thousands of TF regions of highly constrained TF binding intensity. Although individual mutations in bound sequence motifs can influence TF binding, most binding differences occur in the absence of nearby sequence variations. Instead, combinatorial binding was found to be significant for genetic and evolutionary stability; cobound TFs tend to disappear in concert and were sensitive to genetic knockout of partner TFs. The large, qualitative differences in genomic regions bound between closely related mammals, when contrasted with the smaller, quantitative TF binding differences among Drosophila species, illustrate how genome structure and population genetics together shape regulatory evolution.
journal_name
Celljournal_title
Cellauthors
Stefflova K,Thybert D,Wilson MD,Streeter I,Aleksic J,Karagianni P,Brazma A,Adams DJ,Talianidis I,Marioni JC,Flicek P,Odom DTdoi
10.1016/j.cell.2013.07.007subject
Has Abstractpub_date
2013-08-01 00:00:00pages
530-40issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(13)00841-6journal_volume
154pub_type
杂志文章相关文献
CELL文献大全abstract：:Tissue homeostasis requires maintenance of functional integrity under stress. A central source of stress is mechanical force that acts on cells, their nuclei, and chromatin, but how the genome is protected against mechanical stress is unclear. We show that mechanical stretch deforms the nucleus, which cells initially ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.03.052
更新日期：2020-05-14 00:00:00
abstract：:The bHLH-ZIP protein Mad heterodimerizes with Max as a sequence-specific transcriptional repressor. Mad is rapidly induced upon differentiation, and the associated switch from Myc-Max to Mad-Max heterocomplexes seem to repress genes normally activated by Myc-Max. We have identified two related mammalian cDNAs that enc...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90355-0
更新日期：1995-03-10 00:00:00
abstract：:The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcription...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cell.2006.01.002
更新日期：2006-01-27 00:00:00
abstract：:Two key events in Wnt signal transduction, receptor endocytosis and inactivation of Glycogen Synthase Kinase 3 (GSK3), remain incompletely understood. Taelman et al. (2010) discover that Wnt signaling inactivates GSK3 by sequestering the enzyme in multivesicular bodies, thus linking these two events and providing a ne...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2010.12.003
更新日期：2010-12-23 00:00:00
abstract：:A functional cDNA from Aspergillus nidulans encoding triosephosphate isomerase (TPI) was isolated by its ability to complement a tpi1 mutation in Saccharomyces cerevisiae. This cDNA was used to obtain the corresponding gene, tpiA. Alignment of the cDNA and genomic DNA nucleotide sequences indicated that tpiA contains ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90868-8
更新日期：1986-07-04 00:00:00
abstract：:We performed a comprehensive assessment of rare inherited variation in autism spectrum disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD risk, including 24 passing genome-wide Bonferroni correction and 16 new ASD risk gen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.07.015
更新日期：2019-08-08 00:00:00
abstract：:Trigger factor (TF) is a molecular chaperone that binds to bacterial ribosomes where it contacts emerging nascent chains, but TF is also abundant free in the cytosol where its activity is less well characterized. In vitro studies show that TF promotes protein refolding. We find here that ribosome-free TF stably associ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.07.044
更新日期：2009-09-04 00:00:00
abstract：:We present evidence that the genes encoding U3 snRNA in plants are transcribed by RNA polymerase III (pol III) and not by RNA polymerase II (pol II) as in vertebrates or lower eukaryotes. The U3 gene is the only known example of a gene transcribed by different polymerases in different organisms. It is possible to conv...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90469-f
更新日期：1991-05-03 00:00:00
abstract：:Monkey cells synthesizing SV40 large T antigen were lysed and the extracts immunoprecipitated with either monoclonal anti-T antibody or monoclonal antibody to p110-114, the product of the retinoblastoma susceptibility gene (Rb). T and p110-114 coprecipitated in each case, implying that the proteins are complexed with ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90559-4
更新日期：1988-07-15 00:00:00
abstract：:Gene duplication is a major evolutionary force driving adaptation and speciation, as it allows for the acquisition of new functions and can augment or diversify existing functions. Here, we report a gene duplication event that yielded another outcome--the generation of antagonistic functions. One product of this dupli...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.02.046
更新日期：2016-04-07 00:00:00
abstract：:The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00976-0
更新日期：2003-12-12 00:00:00
abstract：:Glial cells are essential components of the nervous system. In this issue, Singhvi et al. uncover cellular and molecular mechanisms through which C. elegans glia shape sensory neuron terminals and thus control animal thermosensing behaviors. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2016.04.052
更新日期：2016-05-05 00:00:00
abstract：:An examination of Abelson murine leukemia virus (A-MuL V)-hematopoietic cell interaction in cultures of fetal tissues reveals that A-MuLV can stimulate the formation of two different types of colonies. One type of colony is white and composed of A-MuLV-transformed lymphoid cells that can develop into established cell ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90035-0
更新日期：1981-10-01 00:00:00
abstract：:The Ion gene of E. coli controls the stability of two bacteriophage lambda proteins. The functional half-life of the phage N gene product, measured by complementation, is increased about 5-fold in Ion mutant strains, from 2 min to 10 min. The chemical half-life of N protein, determined by its disappearance on polyacry...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90518-3
更新日期：1981-04-01 00:00:00
abstract：:The maternal Dorsal regulatory gradient initiates the differentiation of several tissues in the early Drosophila embryo. Whole-genome microarray assays identified as many as 40 new Dorsal target genes, which encode a broad spectrum of cell signaling proteins and transcription factors. Evidence is presented that a tiss...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)01087-5
更新日期：2002-11-27 00:00:00
abstract：:The leader RNA transcript of vesicular stomatitis virus (VSV) has been immunoprecipitated from infected BHK cell extracts by anti-La specific sera from patients with systemic lupus erythematosus (SLE). This association was specific as lupus anti-sera with other specificities failed to precipitate leader RNA. The amoun...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90541-x
更新日期：1983-10-01 00:00:00
abstract：:How transcription is silenced in early embryos has long been a mystery. In this issue, Guven-Ozkan et al. (2008) report that transcriptional repression during worm embryogenesis is mediated through sequestration of the general transcription factor TAF-4 and is regulated by mechanisms that orchestrate the transition be...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2008.09.021
更新日期：2008-10-03 00:00:00
abstract：:The membrane fusion potential of influenza HA, like many viral membrane-fusion glycoproteins, is generated by proteolytic cleavage of a biosynthetic precursor. The three-dimensional structure of ectodomain of the precursor HA0 has been determined and compared with that of cleaved HA. The cleavage site is a prominent s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81771-7
更新日期：1998-10-30 00:00:00
abstract：:Cells released from primary tumors seed metastases to specific organs by a nonrandom process, implying the involvement of biologically selective mechanisms. Based on clinical, functional, and molecular evidence, we show that the cytokine TGFbeta in the breast tumor microenvironment primes cancer cells for metastasis t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.01.046
更新日期：2008-04-04 00:00:00
abstract：:Unique among leukocytes, neutrophils follow daily cycles of release from and migration back into the bone marrow, where they are eliminated. Because removal of dying cells generates homeostatic signals, we explored whether neutrophil elimination triggers circadian events in the steady state. Here, we report that the h...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.04.040
更新日期：2013-05-23 00:00:00
abstract：:We have obtained the complete sequence of cloned full-length DNA (NS DNA) derived from influenza virus gene 8, which codes for two unique polypeptides, NS1 and NS2, and the sequence of the NS2 mRNA. Previously we showed that the mRNA for NS1 (approximately 860 nucleotides) is colinear with the viral RNA and maps from ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90484-5
更新日期：1980-09-01 00:00:00
abstract：:daughterless (da) has multiple functions in Drosophila embryonic development: maternal da activity is necessary for proper sex determination, and zygotic da activity is necessary for formation of the peripheral nervous system. We have cloned the region containing da and have found that five recessive lethal da mutatio...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90250-4
更新日期：1988-12-23 00:00:00
abstract：:The hemagglutinin of influenza virus is synthesized as a monomeric subunit that is cotranslationally translocated across the membrane of the rough endoplasmic reticulum. We show that folding and assembly of hemagglutinin monomers into trimeric structures takes approximately 7-10 min and is completed before the protein...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90076-0
更新日期：1986-09-12 00:00:00
abstract：:In target tissues for estrogen, including breast cancer cells, the synthesis of progesterone receptors (PRs) is controlled by estradiol acting through estrogen receptors (ERs). We describe studies with T47D human breast cancer cells, whose PRs are not regulated by estradiol, though present in extraordinary amounts (30...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90218-5
更新日期：1982-03-01 00:00:00
abstract：:Methylation of arginine residues within histone H3 has been linked to active transcription. This modification appears on the estrogen-regulated pS2 promoter when the CARM1 methyltransferase is recruited during transcriptional activation. Here we describe a process, deimination, that converts histone arginine to citrul...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.08.020
更新日期：2004-09-03 00:00:00
abstract：:The effects of beta-estradiol (estrogen; a minor component of yeast cells) on S. cerevisiae cells in the G0 and G1 phases were examined. Results showed that estrogen stimulated the recovery of growth from G0 arrest induced by nutrient limitation or ts mutation of cdc35 (adenylate cyclase) in the early G1 phase, and in...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90136-0
更新日期：1989-05-19 00:00:00
abstract：SUMMARY:Disruption of the cyclin-dependent kinase-inhibitory domain of p27 enhances growth of mice. Growth is attributed to an increase in cell number, due to increased cell proliferation, most obviously in tissues that ordinarily express p27 at the highest levels. Disruption of p27 function leads to nodular hyperplasi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81238-6
更新日期：1996-05-31 00:00:00
abstract：:Peptide hormone fibroblast growth factor-21 (FGF21) has insulin-mimetic properties. Dutchak et al. now suggest that FGF21 also acts in an autocrine fashion in adipocytes and is required to mediate effects of the PPARγ agonist class of antidiabetic drugs. Does this new property improve FGF21's fledgling clinical prospe...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2012.01.020
更新日期：2012-02-03 00:00:00
abstract：:The fluid-mosaic model posits a liquid-like plasma membrane, which can flow in response to tension gradients. It is widely assumed that membrane flow transmits local changes in membrane tension across the cell in milliseconds, mediating long-range signaling. Here, we show that propagation of membrane tension occurs qu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.09.054
更新日期：2018-12-13 00:00:00
abstract：:Genes are packaged into nucleosomal arrays, each nucleosome typically having two copies of histones H2A, H2B, H3, and H4. Histones have distinct posttranslational modifications, variant isoforms, and dynamics. Whether each histone copy within a nucleosome has distinct properties, particularly in relation to the direct...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.10.054
更新日期：2014-12-04 00:00:00
