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Substrate selectivity APPLies to Akt.

Abstract：

:The protein kinase Akt occupies a central position in multiple signaling pathways. Although numerous Akt substrates have been identified, less is known about the factors that regulate specific cellular responses to Akt signaling. In this issue, Schenck et al. (2008) demonstrate that the endosomal protein Appl1 modulates Akt's substrate selectivity to promote cell survival during zebrafish development.

journal_name

Cell

journal_title

Cell

authors

Zhao S,Guan KL

doi

10.1016/j.cell.2008.04.015

subject

Has Abstract

pub_date

2008-05-02 00:00:00

pages

399-400

issue

3

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(08)00507-2

journal_volume

133

pub_type

评论,杂志文章

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