Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer.


:To investigate the role of the presumed DNA mismatch repair (MMR) gene Msh2 in genome stability and tumorigenesis, we have generated cells and mice that are deficient for the gene. Msh2-deficient cells have lost mismatch binding and have acquired microsatellite instability, a mutator phenotype, and tolerance to methylating agents. Moreover, in these cells, homologous recombination has lost dependence on complete identity between interacting DNA sequences, suggesting that Msh2 is involved in safeguarding the genome from promiscuous recombination. Msh2-deficient mice display no major abnormalities, but a significant fraction develops lymphomas at an early age. Thus, Msh2 is involved in MMR, controlling several aspects of genome stability; loss of MMR-controlled genome stability predisposes to cancer.






de Wind N,Dekker M,Berns A,Radman M,te Riele H




Has Abstract


1995-07-28 00:00:00
















  • Cytohesins are cytoplasmic ErbB receptor activators.

    abstract::Signaling by ErbB receptors requires the activation of their cytoplasmic kinase domains, which is initiated by ligand binding to the receptor ectodomains. Cytoplasmic factors contributing to the activation are unknown. Here we identify members of the cytohesin protein family as such factors. Cytohesin inhibition decre...


    pub_type: 杂志文章,收录出版


    authors: Bill A,Schmitz A,Albertoni B,Song JN,Heukamp LC,Walrafen D,Thorwirth F,Verveer PJ,Zimmer S,Meffert L,Schreiber A,Chatterjee S,Thomas RK,Ullrich RT,Lang T,Famulok M

    更新日期:2010-10-15 00:00:00

  • Scrapie prion protein contains a phosphatidylinositol glycolipid.

    abstract::The scrapie (PrPSc) and cellular (PrPC) prion proteins are encoded by the same gene, and their different properties are thought to arise from posttranslational modifications. We have found a phosphatidylinositol glycolipid on both PrPC and PrP 27-30 (derived from PrPSc by limited proteolysis at the amino terminus). Et...


    pub_type: 杂志文章


    authors: Stahl N,Borchelt DR,Hsiao K,Prusiner SB

    更新日期:1987-10-23 00:00:00

  • Differentiation in the salivary glands of Drosophila melanogaster: characterization of the glue proteins and their developmental appearance.

    abstract::The larval salivary glands of Drosophila melanogaster, which are widely used for cytogenic studies, are also useful for studying the regulation of specific protein synthesis during differentiation. These glands synthesize and secrete massive amounts of a glue which attaches the pupae to the substrate during metamorpho...


    pub_type: 杂志文章


    authors: Beckendorf SK,Kafatos FC

    更新日期:1976-11-01 00:00:00

  • Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.

    abstract::Peptide growth factors may play a role in patterning of the early embryo, particularly in the induction of mesoderm. We have explored the role of fibroblast growth factor (FGF) in early Xenopus development by expressing a dominant negative mutant form of the FGF receptor. Using a functional assay in frog oocytes, we f...


    pub_type: 杂志文章


    authors: Amaya E,Musci TJ,Kirschner MW

    更新日期:1991-07-26 00:00:00

  • It takes a PHD to read the histone code.

    abstract::The pattern of histone modifications, called the histone code, influences transitions between chromatin states and the regulation of transcriptional activity. Four recent papers describe how plant homeodomain (PHD) finger proteins read part of this code. The PHD finger may promote both gene expression and repression t...


    pub_type: 杂志文章,评审


    authors: Mellor J

    更新日期:2006-07-14 00:00:00

  • Intrinsic Immunity Shapes Viral Resistance of Stem Cells.

    abstract::Stem cells are highly resistant to viral infection compared to their differentiated progeny; however, the mechanism is mysterious. Here, we analyzed gene expression in mammalian stem cells and cells at various stages of differentiation. We find that, conserved across species, stem cells express a subset of genes previ...


    pub_type: 杂志文章


    authors: Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM

    更新日期:2018-01-25 00:00:00

  • Factors involved in control of tissue-specific expression of albumin gene.

    abstract::Elements controlling tissue-specific expression of the rat albumin gene reside within roughly 150 bp upstream of the transcriptional initiation site. We show here by DNAase I footprinting assays that at least four distinct factors present in extracts derived from cells expressing albumin interact with these sequences....


    pub_type: 杂志文章


    authors: Cereghini S,Raymondjean M,Carranca AG,Herbomel P,Yaniv M

    更新日期:1987-08-14 00:00:00

  • Saved by the Matrix: UPR Independent Survival under ER Stress.

    abstract::Cells are protected from endoplasmic reticulum stress through the unfolded protein response (UPR). In this issue of Cell, Schinzel, Higuchi-Sanabria, Shalem et al., identify a mechanism that helps cells cope with ER stress but is independent of canonical UPR activation, instead involving the extracellular matrix hyalu...


    pub_type: 评论,杂志文章


    authors: Koopman M,Hetz C,Nollen EAA

    更新日期:2019-11-27 00:00:00

  • Disentangling inborn and acquired immunity in human twins.

    abstract::The human geneticist Archibald Garrod noted in 1931 that, "It is, of necessity, no easy matter to distinguish between immunity which is inborn and that which has been acquired" (The Inborn Factors in Disease). In this issue of Cell, Brodin et al. show that the heritability of blood counts rapidly decreases with age fo...


    pub_type: 评论,杂志文章


    authors: Casanova JL,Abel L

    更新日期:2015-01-15 00:00:00

  • Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways.

    abstract::The mechanisms by which molecular chaperones assist quality control of cytosolic proteins are poorly understood. Analysis of the chaperone requirements for degradation of misfolded variants of a cytosolic protein, the VHL tumor suppressor, reveals that distinct chaperone pathways mediate its folding and quality contro...


    pub_type: 杂志文章


    authors: McClellan AJ,Scott MD,Frydman J

    更新日期:2005-06-03 00:00:00

  • Critical sequences within mitochondrial introns: pleiotropic mRNA maturase and cis-dominant signals of the box intron controlling reductase and oxidase.

    abstract::We have established the DNA sequence of nine yeast mutants that prevent the expression either of the split cytochrome b gene alone (five mutants) or of two split genes, the cytochrome b gene and the cytochrome oxidase subunit I gene (four mutants). All the mutations analyzed are localized in intron 14 of the cob-box g...


    pub_type: 杂志文章


    authors: De La Salle H,Jacq C,Slonimski PP

    更新日期:1982-04-01 00:00:00

  • Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors.

    abstract::We employed gene targeting to study H2AX, a histone variant phosphorylated in chromatin surrounding DNA double-strand breaks. Mice deficient for both H2AX and p53 (H(delta/delta)P(-/-)) rapidly developed immature T and B lymphomas and solid tumors. Moreover, H2AX haploinsufficiency caused genomic instability in normal...


    pub_type: 杂志文章


    authors: Bassing CH,Suh H,Ferguson DO,Chua KF,Manis J,Eckersdorff M,Gleason M,Bronson R,Lee C,Alt FW

    更新日期:2003-08-08 00:00:00

  • The sequential action of miR156 and miR172 regulates developmental timing in Arabidopsis.

    abstract::The transition from the juvenile to the adult phase of shoot development in plants is accompanied by changes in vegetative morphology and an increase in reproductive potential. Here, we describe the regulatory mechanism of this transition. We show that miR156 is necessary and sufficient for the expression of the juven...


    pub_type: 杂志文章


    authors: Wu G,Park MY,Conway SR,Wang JW,Weigel D,Poethig RS

    更新日期:2009-08-21 00:00:00

  • Interaction of positive and negative regulatory proteins in the galactose regulon of yeast.

    abstract::Transcriptional regulation in the galactose regulon of yeast is determined by an interplay between a positive regulatory protein, GAL4, and a negative regulatory protein, GAL80. We show that derivatives of GAL4 missing as few as 28 carboxy-terminal amino acids are not responsive to GAL80 regulation, implying that the ...


    pub_type: 杂志文章


    authors: Johnston SA,Salmeron JM Jr,Dincher SS

    更新日期:1987-07-03 00:00:00

  • p53 regulation orchestrates the TGF-beta response.

    abstract::Among its multiple functions, p53 is a critical regulator of TGF-beta responses. Sasai et al. (2008) now identify a new p53 inhibitory protein, XFDL156. During embryonic development, this factor is expressed in the ectoderm germ layer and maintains the pluripotency of ectodermal cells by inhibiting TGF-beta target gen...


    pub_type: 评论,杂志文章


    authors: Piccolo S

    更新日期:2008-05-30 00:00:00

  • Role of Drosophila alpha-adaptin in presynaptic vesicle recycling.

    abstract::Rapid flow of information in the nervous system involves presynaptic vesicle recycling by clathrin-mediated endocytosis, an event triggered by the alpha-adaptin-containing AP2 complex. We identified a Drosophila alpha-adaptin expressed in the garland cells, imaginal discs, and the CNS. Here we show its role in presyna...


    pub_type: 杂志文章


    authors: González-Gaitán M,Jäckle H

    更新日期:1997-03-21 00:00:00

  • Yeast histone genes show dosage compensation.

    abstract::The copy number of yeast histone genes was increased by inserting an extra H2A,H2B gene pair into the haploid genome by the technique of yeast transformation. The presence of this extra gene copy has no detectable effect on cell growth. The steady-state levels of histone H2A,H2B mRNAs are not elevated in transformed s...


    pub_type: 杂志文章


    authors: Osley MA,Hereford LM

    更新日期:1981-05-01 00:00:00

  • Activation of STAT6 by STING is critical for antiviral innate immunity.

    abstract::STAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular cytokines. We now show that STAT6 is required for innate immune signaling in response to virus infection. Viruses or cytoplasmic nucleic acids trigger STING (also named MITA/ERIS) to recruit STAT6 to the endoplasmic reticulum, ...


    pub_type: 杂志文章


    authors: Chen H,Sun H,You F,Sun W,Zhou X,Chen L,Yang J,Wang Y,Tang H,Guan Y,Xia W,Gu J,Ishikawa H,Gutman D,Barber G,Qin Z,Jiang Z

    更新日期:2011-10-14 00:00:00

  • A deeper look into translation initiation.

    abstract::Eukaryotic translation initiation requires coordinated assembly of a remarkable array of initiation factors onto the small ribosomal subunit to select an appropriate mRNA start codon. Studies from Erzberger et al. and Hussain et al. bring new insights into this mechanism by looking at early and late initiation interme...


    pub_type: 评论,杂志文章


    authors: Korostelev AA

    更新日期:2014-10-23 00:00:00

  • Role of small t antigen in the acute transforming activity of SV40.

    abstract::A plasmid, pHR402, containing SV40 sequences that include a truncated early region bearing an intact t-coding sequence and a functionally intact late region, was introduced into thymidine kinase deficient (tk-) mouse L cells by cotransformation with a cloned tk gene. tk+ cotransformants synthesized SV40 t but not T an...


    pub_type: 杂志文章


    authors: Rubin H,Figge J,Bladon MT,Chen LB,Ellman M,Bikel I,Farrell M,Livingston DM

    更新日期:1982-09-01 00:00:00

  • Mistranslation in a eucaryotic organism.

    abstract::Previous work from our laboratory has demonstrated that a subclass of the aminoglycoside antibiotics, those containing the drug fragment paromamine, stimulates mistranslation in cell-free protein-synthesizing systems derived from eucaryotic cells. We report here experiments which show that the ciliate Tetrahymena ther...


    pub_type: 杂志文章


    authors: Palmer E,Wilhelm JM

    更新日期:1978-02-01 00:00:00

  • Evidence that Armadillo transduces wingless by mediating nuclear export or cytosolic activation of Pangolin.

    abstract::Secreted proteins of the Wnt family have profound organizing roles during animal development and are transduced via the activities of the Frizzled (Fz) class of transmembrane receptors and the TCF/LEF/Pangolin class of transcription factors. beta-catenins, including Drosophila Armadillo (Arm), link activation of Fz at...


    pub_type: 杂志文章,收录出版


    authors: Chan SK,Struhl G

    更新日期:2002-10-18 00:00:00

  • CHL1 functions as a nitrate sensor in plants.

    abstract::Ions serve as essential nutrients in higher plants and can also act as signaling molecules. Little is known about how plants sense changes in soil nutrient concentrations. Previous studies showed that T101-phosphorylated CHL1 is a high-affinity nitrate transporter, whereas T101-dephosphorylated CHL1 is a low-affinity ...


    pub_type: 杂志文章


    authors: Ho CH,Lin SH,Hu HC,Tsay YF

    更新日期:2009-09-18 00:00:00

  • Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies.

    abstract::Generation of potent antibodies by a mutation-selection process called affinity maturation is a key component of effective immune responses. Antibodies that protect against highly mutable pathogens must neutralize diverse strains. Developing effective immunization strategies to drive their evolution requires understan...


    pub_type: 杂志文章


    authors: Wang S,Mata-Fink J,Kriegsman B,Hanson M,Irvine DJ,Eisen HN,Burton DR,Wittrup KD,Kardar M,Chakraborty AK

    更新日期:2015-02-12 00:00:00

  • Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.

    abstract::Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a growing public health concern. Systems-level analysis of how flaviviruses hijack cellular processes through virus-host protein-protein interactions (PPIs) provides information about their replication and pathogenic mechanisms. We u...


    pub_type: 杂志文章


    authors: Shah PS,Link N,Jang GM,Sharp PP,Zhu T,Swaney DL,Johnson JR,Von Dollen J,Ramage HR,Satkamp L,Newton B,Hüttenhain R,Petit MJ,Baum T,Everitt A,Laufman O,Tassetto M,Shales M,Stevenson E,Iglesias GN,Shokat L,Tripathi

    更新日期:2018-12-13 00:00:00

  • Alleles of the APC gene: an attenuated form of familial polyposis.

    abstract::An attenuated form of familial adenomatous polyposis coli, AAPC, causes relatively few colonic polyps, but still carries a significant risk of colon cancer. The mutant alleles responsible for this attenuated phenotype have been mapped in several families to the adenomatous polyposis coli (APC) locus on human chromosom...


    pub_type: 杂志文章


    authors: Spirio L,Olschwang S,Groden J,Robertson M,Samowitz W,Joslyn G,Gelbert L,Thliveris A,Carlson M,Otterud B

    更新日期:1993-12-03 00:00:00

  • Senescence in Podospora anserina: amplification of a mitochondrial DNA sequence.

    abstract::Senescence in Podospora anserina has long been shown to be under cytoplasmic control. Comparison of DNAs isolated from young and senescent cultures made it possible to detect the presence, in senescent cultures only, of a specific DNA (SEN-DNA). This DNA consists of repeated sequences arranged in a multimeric set of c...


    pub_type: 杂志文章


    authors: Jamet-Vierny C,Begel O,Belcour L

    更新日期:1980-08-01 00:00:00

  • Tissue Determinants of Human NK Cell Development, Function, and Residence.

    abstract::Immune responses in diverse tissue sites are critical for protective immunity and homeostasis. Here, we investigate how tissue localization regulates the development and function of human natural killer (NK) cells, innate lymphocytes important for anti-viral and tumor immunity. Integrating high-dimensional analysis of...


    pub_type: 杂志文章


    authors: Dogra P,Rancan C,Ma W,Toth M,Senda T,Carpenter DJ,Kubota M,Matsumoto R,Thapa P,Szabo PA,Li Poon MM,Li J,Arakawa-Hoyt J,Shen Y,Fong L,Lanier LL,Farber DL

    更新日期:2020-02-20 00:00:00

  • Lessons from a failed γ-secretase Alzheimer trial.

    abstract::γ-Secretase proteases have been associated with pathology in Alzheimer disease (AD), but we are just beginning to understand their basic mechanisms and physiological roles. A negative drug trial with a broad spectrum γ-secretase inhibitor in AD patients has severely dampened enthusiasm for the potential of pursuing γ-...


    pub_type: 杂志文章


    authors: De Strooper B

    更新日期:2014-11-06 00:00:00

  • Identification of mouse sperm SED1, a bimotif EGF repeat and discoidin-domain protein involved in sperm-egg binding.

    abstract::We report the identification of SED1, a protein required for mouse sperm binding to the egg zona pellucida. SED1 is homologous to a small group of secreted cell-matrix adhesive proteins that contain Notch-like EGF repeats and discoidin/F5/8 type C domains. SED1 is expressed in spermatogenic cells and is secreted by th...


    pub_type: 杂志文章


    authors: Ensslin MA,Shur BD

    更新日期:2003-08-22 00:00:00