Abstract：
:The CD4 lymphocyte surface glycoprotein and the lck tyrosine protein kinase p56lck are found as a complex in T lymphocytes. We have defined the domains in both proteins that are responsible for this interaction by coexpressing hybrid and deleted forms of the two proteins in HeLa cells. We have found that the unique 32 amino-terminal residues of p56lck and the 38 carboxy-terminal residues of CD4 that comprise the cytoplasmic domain are both necessary and sufficient by themselves for the interaction of the two proteins. The interaction appears to be independent of other T cell-specific proteins and probably occurs before CD4 reaches the cell surface. Our findings suggest that the specialized amino-terminal domains of other members of the src family of intracellular tyrosine kinases may also mediate transmembrane signaling via coupling to the cytoplasmic domains of specific transmembrane proteins.
journal_name
Celljournal_title
Cellauthors
Shaw AS,Amrein KE,Hammond C,Stern DF,Sefton BM,Rose JKdoi
10.1016/0092-8674(89)90008-1subject
Has Abstractpub_date
1989-11-17 00:00:00pages
627-36issue
4eissn
0092-8674issn
1097-4172pii
0092-8674(89)90008-1journal_volume
59pub_type
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