Abstract：
:Cellular ras activity has been neutralized in 3T3 cells by microinjection of a specific anti-ras monoclonal antibody. The injected antibody efficiently inhibited proliferation in cells treated with a phorbol ester and a calcium ionophore, or with prostaglandin F2 alpha. These treatments were designed to imitate the action of phospholipase C or of phospholipase A2. In addition, the highly efficient mitogenic potential of phosphatidic acid was inhibited by the injected antibody even more efficiently than was serum-induced proliferation. The close reliance of phospholipid-induced mitogenesis upon ras activity suggests that ras proteins are unlikely to function to control the action of a phospholipase.
journal_name
Celljournal_title
Cellauthors
Yu CL,Tsai MH,Stacey DWdoi
10.1016/0092-8674(88)90531-4subject
Has Abstractpub_date
1988-01-15 00:00:00pages
63-71issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(88)90531-4journal_volume
52pub_type
杂志文章相关文献
CELL文献大全abstract：:Leukocyte adhesion deficiency (LAD) is a heritable disease involving deficient expression of three related leukocyte adhesion glycoproteins: LFA-1, Mac-1, and p150,95. These proteins are alpha beta heterodimers containing identical 95,000 dalton beta subunits. Here we demonstrate that the primary defect in LAD is in t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90215-7
更新日期：1987-07-17 00:00:00
abstract：:Conditions are described for programming with active transcription complexes essentially all the Xenopus 5S RNA genes added to an extract of Xenopus oocyte nuclei. We call this rate enhancement. Transcription by SP6 RNA polymerase of either strand of a Xenopus 5S RNA gene is unimpeded by the presence of a complete tra...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90459-9
更新日期：1986-02-14 00:00:00
abstract：:Vascular permeability is frequently associated with inflammation and is triggered by a cohort of secreted permeability factors such as vascular endothelial growth factor (VEGF). Here, we show that the physiological vascular permeability that precedes implantation is directly controlled by progesterone receptor (PR) an...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.12.025
更新日期：2014-01-30 00:00:00
abstract：:The protein Par-4 acts in the cytoplasm to trigger cell death signaling via caspase activation and the mitochondrial release of cytochrome c. Burikhanov et al. (2009) now provide surprising evidence that Par-4 can also promote apoptosis from outside the cell, after its secretion in response to endoplasmic reticulum st...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2009.07.007
更新日期：2009-07-23 00:00:00
abstract：:We have purified and characterized a modified peptide pheromone that accumulates in culture medium as B. subtilis grows to high density. This pheromone is required for the development of genetic competence. When added to cells at low density, the pheromone induces the premature development of competence. The peptide m...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(94)90313-1
更新日期：1994-04-22 00:00:00
abstract：:E2F is a transcription factor believed to play a role in the activation of genes required for cellular proliferation. Its regulation is likely important for maintenance of G0 and for the initiation of cell growth. The retinoblastoma product (RB) forms a complex with E2F in G1 in primary and established human cells. As...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90214-w
更新日期：1992-01-10 00:00:00
abstract：:We are undertaking a genetic approach to investigate the role that synaptic modulation in the mammalian central nervous system plays in learning and memory and to identify relevant molecular components. We have generated mice deficient in the gamma isoform of protein kinase C (PKC gamma), an enzyme that has previously...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90614-v
更新日期：1993-12-31 00:00:00
abstract：:A diverse range of ultimate chemical carcinogens inhibited the transfer of methyl groups from S-adenosylmethionine to hemimethylated DNA in a reaction catalyzed by mouse spleen methyltransferase. The formation of alkali-labile sites in DNA lessened its ability to accept methyl groups in vitro, but the methylation reac...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90514-7
更新日期：1983-01-01 00:00:00
abstract：:Rapid flow of information in the nervous system involves presynaptic vesicle recycling by clathrin-mediated endocytosis, an event triggered by the alpha-adaptin-containing AP2 complex. We identified a Drosophila alpha-adaptin expressed in the garland cells, imaginal discs, and the CNS. Here we show its role in presyna...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81923-6
更新日期：1997-03-21 00:00:00
abstract：:A major challenge to understanding how cells work together in the central nervous system (CNS) is the heterogeneous cellular composition of the brain. In this issue, Heiman et al. (2008) and Doyle et al. (2008) introduce a new strategy (TRAP) that enables the profiling of translated mRNAs in specific CNS cell populati...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2008.10.031
更新日期：2008-11-14 00:00:00
abstract：:Transcription hinders replication fork progression and stability. The ATR checkpoint and specialized DNA helicases assist DNA synthesis across transcription units to protect genome integrity. Combining genomic and genetic approaches together with the analysis of replication intermediates, we searched for factors coord...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.09.041
更新日期：2012-11-09 00:00:00
abstract：:DNA repair is an essential process for preserving genome integrity in all organisms. In eukaryotes, recombinational repair is choreographed by multiprotein complexes that are organized into centers (foci). Here, we analyze the cellular response to DNA double-strand breaks (DSBs) and replication stress in Saccharomyces...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.08.015
更新日期：2004-09-17 00:00:00
abstract：:Huntington's disease (HD) is an incurable neuropsychiatric disease associated with CAG repeat expansion within a widely expressed gene that causes selective neuronal death. To understand its normal function, we have created a targeted disruption in exon 5 of Hdh (Hdhex5), the murine homolog of the HD gene. Homozygotes...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90542-1
更新日期：1995-06-02 00:00:00
abstract：:The molecular basis for membrane association of pp60v-src, the transforming protein of Rous sarcoma virus, was investigated in a cell-free system. Newly synthesized pp60v-src polypeptide, produced by in vitro translation of src mRNA, rapidly bound to plasma membranes. Binding was saturable and dependent on the presenc...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90842-8
更新日期：1989-07-28 00:00:00
abstract：:Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin-1 (PS1). In PS1 null blastocysts, neurons from mice hypomorphic for PS1 or conditionally depleted of PS1, substrate proteolysis and autopha...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.05.008
更新日期：2010-06-25 00:00:00
abstract：:Linear simian virus 40 (SV40) chromosomes were prepared by Eco R1 nuclease cleavage of the circular SV40 chromosomes released from virions with dithiothreitol at pH 9,8. Chromatin-DNA hybrids were constructed with segments of 3H-labeled, naked SV40 DNA covalently joined via the Eco R1-generated cohesive ends to segmen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90279-9
更新日期：1978-11-01 00:00:00
abstract：:DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retr...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2015.08.005
更新日期：2015-08-27 00:00:00
abstract：:The double-stranded RNA-activated protein kinase (PKR) was originally identified as a sensor of virus infection, but its function in the brain remains unknown. Here, we report that the lack of PKR enhances learning and memory in several behavioral tasks while increasing network excitability. In addition, loss of PKR i...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.11.029
更新日期：2011-12-09 00:00:00
abstract：:We present a strategy for generating and analyzing comprehensive genetic-interaction maps, termed E-MAPs (epistatic miniarray profiles), comprising quantitative measures of aggravating or alleviating interactions between gene pairs. Crucial to the interpretation of E-MAPs is their high-density nature made possible by ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.08.031
更新日期：2005-11-04 00:00:00
abstract：:The small ribosomal subunit performs the decoding of genetic information during translation. The structure of that from Thermus thermophilus shows that the decoding center, which positions mRNA and three tRNAs, is constructed entirely of RNA. The entrance to the mRNA channel will encircle the message when a latch-like...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)00084-2
更新日期：2000-09-01 00:00:00
abstract：:While mutations affecting protein-coding regions have been examined across many cancers, structural variants at the genome-wide level are still poorly defined. Through integrative deep whole-genome and -transcriptome analysis of 101 castration-resistant prostate cancer metastases (109X tumor/38X normal coverage), we i...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.06.039
更新日期：2018-07-26 00:00:00
abstract：:HNF-3 beta, a transcription factor of the winged-helix family, is expressed in embryonic and adult endoderm and also in midline cells of the node, notochord, and floor plate in mouse embryos. To define the function of HNF-3 beta, a targeted mutation in the HNF-3 beta locus was generated by homologous recombination in ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(94)90523-1
更新日期：1994-08-26 00:00:00
abstract：:In this issue of Cell, discover gene-specific translational silencing as a novel function of the fused glutamyl- and prolyl-tRNA synthetase (GluProRS). GluProRS is released from a multisynthetase translation complex in response to gamma-interferon and forms a four-protein GAIT complex that silences translation of ceru...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2004.10.001
更新日期：2004-10-15 00:00:00
abstract：:We have developed an in vitro system utilizing yeast cell-free extracts to catalyze recombination events between homologous plasmids containing different mutant alleles of the Tet or ARG4 genes. The reaction increased the frequency of Tcr or Arg+ transformants (recombinants) from 2 X 10(-6) to 1-3 X 10(-3). Linearizin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90113-7
更新日期：1983-12-01 00:00:00
abstract：:Living organisms sense their physical environment through cellular mechanotransduction, which converts mechanical forces into electrical and biochemical signals. In turn, signal transduction serves a wide variety of functions, from basic cellular processes as diverse as proliferation, differentiation, migration, and a...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2013.09.026
更新日期：2013-10-10 00:00:00
abstract：:The detection and discrimination of odorants in mammals is thought to be mediated by a family of 100-1000 seven transmembrane domain receptor proteins, although none of these putative olfactory receptors have been shown to bind individual odorants with high affinity. We have used a genetic approach to identify the gen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90118-3
更新日期：1995-11-03 00:00:00
abstract：:Certain mutant alleles at the low density lipoprotein (LDL) receptor locus produce receptors that bind LDL normally, but fail to cluster in coated pits and therefore cannot transport LDL into cells. We prepared genomic DNA libraries from cells of two individuals with this phenotype (internalization-defective familial ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(85)80054-4
更新日期：1985-07-01 00:00:00
abstract：:NPR1 is an essential regulator of plant systemic acquired resistance (SAR), which confers immunity to a broad-spectrum of pathogens. SAR induction results in accumulation of the signal molecule salicylic acid (SA), which induces defense gene expression via activation of NPR1. We found that in an uninduced state, NPR1 ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00429-x
更新日期：2003-06-27 00:00:00
abstract：:Interaction between CD2 and its counterreceptor, CD58 (LFA-3), on opposing cells optimizes immune recognition, facilitating contacts between helper T lymphocytes and antigen-presenting cells as well as between cytolytic effectors and target cells. Here, we report the crystal structure of the heterophilic adhesion comp...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80790-4
更新日期：1999-06-11 00:00:00
abstract：:What happens to organelles during mitosis, and how they are apportioned to each of the daughter cells, is not completely clear. We have devised a procedure to address whether Golgi membranes fuse with the Endoplasmic Reticulum (ER) during mitosis via the detection of interactions between ER and Golgi proteins. This pr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)01068-7
更新日期：2004-01-09 00:00:00
