A bacteriophage RNA polymerase transcribes through a Xenopus 5S RNA gene transcription complex without disrupting it.

abstract：:Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why these events occur, just as the theory of gravitation allows one to understand why cannonballs fly in parabolic arcs. The simplest examples of the eukaryotic ce...

journal_title：Cell

authors： Ferrell JE Jr,Tsai TY,Yang Q

更新日期：2011-03-18 00:00:00

abstract：:Activation of Agouti-related peptide (AgRP) neurons potently promotes feeding, and chronically altering their activity also affects peripheral glucose homeostasis. We demonstrate that acute activation of AgRP neurons causes insulin resistance through impairment of insulin-stimulated glucose uptake into brown adipose t...

journal_title：Cell

authors： Steculorum SM,Ruud J,Karakasilioti I,Backes H,Engström Ruud L,Timper K,Hess ME,Tsaousidou E,Mauer J,Vogt MC,Paeger L,Bremser S,Klein AC,Morgan DA,Frommolt P,Brinkkötter PT,Hammerschmidt P,Benzing T,Rahmouni K,Wunder

更新日期：2016-03-24 00:00:00

abstract：:Some Ts in nuclear DNA of trypanosomes and Leishmania are hydroxylated and glucosylated to yield base J (β-D-glucosyl-hydroxymethyluracil). In Leishmania, about 99% of J is located in telomeric repeats. We show here that most of the remaining J is located at chromosome-internal RNA polymerase II termination sites. Thi...

journal_title：Cell

authors： van Luenen HG,Farris C,Jan S,Genest PA,Tripathi P,Velds A,Kerkhoven RM,Nieuwland M,Haydock A,Ramasamy G,Vainio S,Heidebrecht T,Perrakis A,Pagie L,van Steensel B,Myler PJ,Borst P

更新日期：2012-08-31 00:00:00

abstract：:Vertebrate Hoxd genes are sequentially activated during the morphogenesis and pattern formation of the limb. Using the approach of gene disruption via homologous recombination in embryonic stem cells, we have assessed the function of the last gene of the complex, Hoxd-13. Mutant mice displayed skeletal alterations alo...

journal_title：Cell

authors： Dollé P,Dierich A,LeMeur M,Schimmang T,Schuhbaur B,Chambon P,Duboule D

更新日期：1993-11-05 00:00:00

abstract：:How chaperonins orchestrate the successful folding of even the most elaborate of proteins is a question of central importance. In two recent studies in Cell by Joachimiak et al. and Freund et al., a new class of TRiC substrate is identified, and how the chaperonin exploits its different subunits to extend its substrat...

journal_title：Cell

authors： Zhuravleva A,Radford SE

更新日期：2014-12-04 00:00:00

abstract：:The copy number of yeast histone genes was increased by inserting an extra H2A,H2B gene pair into the haploid genome by the technique of yeast transformation. The presence of this extra gene copy has no detectable effect on cell growth. The steady-state levels of histone H2A,H2B mRNAs are not elevated in transformed s...

journal_title：Cell

authors： Osley MA,Hereford LM

更新日期：1981-05-01 00:00:00

abstract：:The posttranslational conversion of cysteine to C(alpha)-formylglycine in the catalytic site of mammalian sulfatases is deficient in the rare but devastating disorder multiple sulfatase deficiency (MSD). Two papers in this issue of Cell report the cloning of a gene responsible for this activity. ...

journal_title：Cell

authors： Baenziger JU

更新日期：2003-05-16 00:00:00

abstract：:Organisms maintain the correct balance of intracellular metals primarily through metal-sensing proteins that control transport and storage of the target ion(s). Here, we reveal the basis of metal sensing and genetic control by a metalloregulatory RNA. Our data demonstrate that a previously uncharacterized orphan ribos...

journal_title：Cell

authors： Dann CE 3rd,Wakeman CA,Sieling CL,Baker SC,Irnov I,Winkler WC

更新日期：2007-09-07 00:00:00

abstract：:We have shown that covalent conjugation of ubiquitin to proteins is temperature-sensitive in the mouse cell cycle mutant ts85 due to a specifically thermolabile ubiquitin-activating enzyme (accompanying paper). We show here that degradation of short-lived proteins is also temperature sensitive in ts85 , in contrast to...

journal_title：Cell

authors： Ciechanover A,Finley D,Varshavsky A

更新日期：1984-05-01 00:00:00

abstract：:While developing an assay to measure the activity of the tat protein from human immunodeficiency virus 1 (HIV-1), we discovered that the purified protein could be taken up by cells growing in tissue culture and subsequently trans-activate the viral promoter. Trans-activation is dramatically increased by a variety of l...

journal_title：Cell

authors： Frankel AD,Pabo CO

更新日期：1988-12-23 00:00:00

abstract：:Cytoplasmic dynein is a motor protein that exerts force on microtubules. To generate force for the movement of large organelles, dynein needs to be anchored, with the anchoring sites being typically located at the cell cortex. However, the mechanism by which dyneins target sites where they can generate large collectiv...

journal_title：Cell

authors： Ananthanarayanan V,Schattat M,Vogel SK,Krull A,Pavin N,Tolić-Nørrelykke IM

更新日期：2013-06-20 00:00:00

abstract：:In this issue of Cell, use live-fluorescence microscopy to monitor individual genomic loci as they replicate in budding yeast. They confirm that DNA is recruited to replication factories and show that sister replication forks initiated from the same origin are held together within a single replication factory. ...

journal_title：Cell

authors： Meister P,Taddei A,Gasser SM

更新日期：2006-06-30 00:00:00

abstract：:The trk tyrosine kinase proto-oncogene product gp140prototrk binds nerve growth factor (NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine whether gp140prototrk is involved in transducing a functional NGF signal, PC12 cell mutants (PC12nnr) deficient in high affinity NGF binding an...

journal_title：Cell

authors： Loeb DM,Maragos J,Martin-Zanca D,Chao MV,Parada LF,Greene LA

更新日期：1991-09-06 00:00:00

abstract：:NRK fibroblasts exposed to transforming growth factor-beta (TGF-beta) show increased binding of radiolabeled epidermal growth factor (EGF) relative to untreated cells. The binding of another growth factor, rat insulin-like growth factor-II, is unaffected. The increase in EGF binding induced by TGF-beta is not due to i...

journal_title：Cell

authors： Assoian RK,Frolik CA,Roberts AB,Miller DM,Sporn MB

更新日期：1984-01-01 00:00:00

abstract：:Dietary restriction (DR) extends lifespan in multiple species. To examine the mechanisms of lifespan extension upon DR, we assayed genome-wide translational changes in Drosophila. A number of nuclear encoded mitochondrial genes, including those in Complex I and IV of the electron transport chain, showed increased ribo...

journal_title：Cell

authors： Zid BM,Rogers AN,Katewa SD,Vargas MA,Kolipinski MC,Lu TA,Benzer S,Kapahi P

更新日期：2009-10-02 00:00:00

abstract：:ATRX is an X-linked gene of the SWI/SNF family, mutations in which cause syndromal mental retardation and downregulation of α-globin expression. Here we show that ATRX binds to tandem repeat (TR) sequences in both telomeres and euchromatin. Genes associated with these TRs can be dysregulated when ATRX is mutated, and ...

journal_title：Cell

authors： Law MJ,Lower KM,Voon HP,Hughes JR,Garrick D,Viprakasit V,Mitson M,De Gobbi M,Marra M,Morris A,Abbott A,Wilder SP,Taylor S,Santos GM,Cross J,Ayyub H,Jones S,Ragoussis J,Rhodes D,Dunham I,Higgs DR,Gibbons RJ

更新日期：2010-10-29 00:00:00

abstract：:Neurodegenerative diseases can occur so early as to affect neurodevelopment. From a cohort of more than 2,000 consanguineous families with childhood neurological disease, we identified a founder mutation in four independent pedigrees in cleavage and polyadenylation factor I subunit 1 (CLP1). CLP1 is a multifunctional ...

journal_title：Cell

authors： Schaffer AE,Eggens VR,Caglayan AO,Reuter MS,Scott E,Coufal NG,Silhavy JL,Xue Y,Kayserili H,Yasuno K,Rosti RO,Abdellateef M,Caglar C,Kasher PR,Cazemier JL,Weterman MA,Cantagrel V,Cai N,Zweier C,Altunoglu U,Satkin N

更新日期：2014-04-24 00:00:00

abstract：:The mRNAs from two yeast mitochondrial genes cob-box (cytochrome b) and oxi-3 (cytochrome oxidase 40,000 dalton subunit) are processed from large (7-10 kb) precursors. Certain mutations in each gene block the maturation of the RNAs from both genes at a variety of specific steps. The pleiotropic cytochrome b mutants se...

journal_title：Cell

authors： Church GM,Slonimski PP,Gilbert W

更新日期：1979-12-01 00:00:00

abstract：:The non-receptor protein tyrosine phosphatase (PTP) SHP2, encoded by PTPN11, plays an essential role in RAS-mitogen-activated protein kinase (MAPK) signaling during normal development. It has been perplexing as to why both enzymatically activating and inactivating mutations in PTPN11 result in human developmental diso...

journal_title：Cell

authors： Zhu G,Xie J,Kong W,Xie J,Li Y,Du L,Zheng Q,Sun L,Guan M,Li H,Zhu T,He H,Liu Z,Xia X,Kan C,Tao Y,Shen HC,Li D,Wang S,Yu Y,Yu ZH,Zhang ZY,Liu C,Zhu J

更新日期：2020-10-15 00:00:00

abstract：:Neurotrophic factors are essential for neuronal survival and function. Recent data have demonstrated that the product of the tyrosine kinase trk proto-oncogene binds NGF and is a component of the high affinity NGF receptor. Analysis of the trkB gene product, gp145trkB, in NIH 3T3 cells indicates that this tyrosine kin...

journal_title：Cell

authors： Soppet D,Escandon E,Maragos J,Middlemas DS,Reid SW,Blair J,Burton LE,Stanton BR,Kaplan DR,Hunter T,Nikolics K,Parada LF

更新日期：1991-05-31 00:00:00

abstract：:Removal of histone H1 produces a transition in the structure of chromatin fibers as observed by electron microscopy. Chromatin containing all histone proteins appears as fibers with a diameter of about 250 A. The nucleosomes within these fibers are closely packed. If histone H1 is selectively removed with 50-100 mM Na...

journal_title：Cell

authors： Thoma F,Koller T

更新日期：1977-09-01 00:00:00

abstract：:The tumor microenvironment is known to play an important role in tumorigenesis. In this issue, Yang et al. (2008) demonstrate that mast cells heterozygous for the Nf1 gene promote the growth of neurofibromas in a mouse model of neurofibromatosis and that genetic and pharmacological inhibition of these cells is suffici...

journal_title：Cell

authors： Reilly KM,Van Dyke T

更新日期：2008-10-31 00:00:00

abstract：:Angiogenesis is an important event for embryonic organogenesis as well as for tissue repair in the adult. Here, we show that hematopoietic stem cells (HSCs) play important roles for angiogenesis during embryogenesis. To investigate the role of HSCs in endothelial cell (EC) development, we analyzed AML1-deficient embry...

journal_title：Cell

authors： Takakura N,Watanabe T,Suenobu S,Yamada Y,Noda T,Ito Y,Satake M,Suda T

更新日期：2000-07-21 00:00:00

abstract：:Activation of plasma membrane calcium channels by depletion of endoplasmic reticulum (ER) calcium stores is important for calcium entry in many cell types. Park et al. (2009) now show that direct binding of the ER protein STIM to tetramers of the Orai1 calcium channel in the plasma membrane triggers opening of this ch...

journal_title：Cell

authors： Clapham DE

更新日期：2009-03-06 00:00:00

abstract：:Understanding molecular mechanisms that dictate B cell diversity is important for targeting B cells as anti-cancer treatment. Through the single-cell dissection of B cell heterogeneity in longitudinal samples of patients with breast cancer before and after neoadjuvant chemotherapy, we revealed that an ICOSL+ B cell su...

journal_title：Cell

authors： Lu Y,Zhao Q,Liao JY,Song E,Xia Q,Pan J,Li Y,Li J,Zhou B,Ye Y,Di C,Yu S,Zeng Y,Su S

更新日期：2020-03-19 00:00:00

abstract：:Complex gene regulatory networks require transcription factors (TFs) to bind distinct DNA sequences. To understand how novel TF specificity evolves, we combined phylogenetic, biochemical, and biophysical approaches to interrogate how DNA recognition diversified in the steroid hormone receptor (SR) family. After duplic...

journal_title：Cell

authors： McKeown AN,Bridgham JT,Anderson DW,Murphy MN,Ortlund EA,Thornton JW

更新日期：2014-09-25 00:00:00

abstract：:Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsaturated fatty acids into cellular membranes, and cells have dev...

journal_title：Cell

authors： Stockwell BR,Friedmann Angeli JP,Bayir H,Bush AI,Conrad M,Dixon SJ,Fulda S,Gascón S,Hatzios SK,Kagan VE,Noel K,Jiang X,Linkermann A,Murphy ME,Overholtzer M,Oyagi A,Pagnussat GC,Park J,Ran Q,Rosenfeld CS,Salnikow K

更新日期：2017-10-05 00:00:00

abstract：:Ischemia-associated oxidative damage leading to necrosis is a major cause of catastrophic tissue loss, and elucidating its signaling mechanism is therefore of paramount importance. p53 is a central stress sensor responding to multiple insults, including oxidative stress to orchestrate apoptotic and autophagic cell dea...

journal_title：Cell

authors： Vaseva AV,Marchenko ND,Ji K,Tsirka SE,Holzmann S,Moll UM

更新日期：2012-06-22 00:00:00

abstract：:Neurons in the cerebral cortex connect through descending pathways to hindbrain and spinal cord to activate muscle and generate movement. Although components of this pathway have been previously generated and studied in vitro, the assembly of this multi-synaptic circuit has not yet been achieved with human cells. Here...

journal_title：Cell

authors： Andersen J,Revah O,Miura Y,Thom N,Amin ND,Kelley KW,Singh M,Chen X,Thete MV,Walczak EM,Vogel H,Fan HC,Paşca SP

更新日期：2020-12-23 00:00:00

abstract：:A unique DNA structural intermediate associated with termination of replication in Bacillus subtilis has been identified. This was achieved by probing for the Bam HI DNA fragment within which the terminus of the chromosome (terC) resides. The intermediate migrates more slowly than the bulk of digested chromosomal DNA ...

journal_title：Cell

authors： Weiss AS,Wake RG

更新日期：1984-12-01 00:00:00