Abstract:
:In this issue of Cell, use live-fluorescence microscopy to monitor individual genomic loci as they replicate in budding yeast. They confirm that DNA is recruited to replication factories and show that sister replication forks initiated from the same origin are held together within a single replication factory.
journal_name
Celljournal_title
Cellauthors
Meister P,Taddei A,Gasser SMdoi
10.1016/j.cell.2006.06.014subject
Has Abstractpub_date
2006-06-30 00:00:00pages
1233-5issue
7eissn
0092-8674issn
1097-4172pii
S0092-8674(06)00772-0journal_volume
125pub_type
评论,杂志文章相关文献
CELL文献大全abstract::Atopic dermatitis (AD) is a chronic itch and inflammatory disorder of the skin that affects one in ten people. Patients suffering from severe AD eventually progress to develop asthma and allergic rhinitis, in a process known as the "atopic march." Signaling between epithelial cells and innate immune cells via the cyto...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.08.057
更新日期:2013-10-10 00:00:00
abstract::Nuclear exclusion of the forkhead transcription factor FOXO3a by protein kinase Akt contributes to cell survival. We investigated the pathological relationship between phosphoylated-Akt (Akt-p) and FOXO3a in primary tumors. Surprisingly, FOXO3a was found to be excluded from the nuclei of some tumors lacking Akt-p, sug...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(04)00302-2
更新日期:2004-04-16 00:00:00
abstract::Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads to an increase in the N...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.05.016
更新日期:2014-06-19 00:00:00
abstract::The crystal structure of a proteolytic subfragment from scallop striated muscle myosin, complexed with MgADP, has been solved at 2.5 A resolution and reveals an unusual conformation of the myosin head. The converter and the lever arm are in very different positions from those in either the pre-power stroke or near-rig...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80756-4
更新日期:1999-05-14 00:00:00
abstract::Immune homeostasis in the intestine involves complex interactions between microbial organisms and host cells. In this issue, Garrett et al. (2007) describe a communicable form of colitis that is induced by deficiency of the transcription factor T-bet in cells of the innate immune system. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2007.09.030
更新日期:2007-10-05 00:00:00
abstract::An adaptive variant of the human Ectodysplasin receptor, EDARV370A, is one of the strongest candidates of recent positive selection from genome-wide scans. We have modeled EDAR370A in mice and characterized its phenotype and evolutionary origins in humans. Our computational analysis suggests the allele arose in centra...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.01.016
更新日期:2013-02-14 00:00:00
abstract::Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable methods to identify and interrogate pathways involved in pancreatic tumorigenesis are urgently needed. We established organoid models from normal and neoplastic murine and human pancreas tiss...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.12.021
更新日期:2015-01-15 00:00:00
abstract::We have identified in mice an allele of a new T cell receptor V beta gene, V beta 17a, whose product is bound by the monoclonal antibody KJ23a. Over 90% of T cell hybridomas prepared from V beta 17a+ T cells of SWR mice respond to allogeneic forms of the IE class II MHC protein, indicating that V beta 17a has an appre...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90567-8
更新日期:1987-04-24 00:00:00
abstract::The broad expression of the insulin receptor suggests that the spectrum of insulin function has not been fully described. A cell type expressing this receptor is the osteoblast, a bone-specific cell favoring glucose metabolism through a hormone, osteocalcin, that becomes active once uncarboxylated. We show here that i...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2010.06.003
更新日期:2010-07-23 00:00:00
abstract::Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2014.04.008
更新日期:2014-04-24 00:00:00
abstract::We have shown that in fixed mitotic chromosomes from female G. gerbillus cells the inactive X chromosome is distinctly less sensitive to DNAase I than the active X chromosome, as demonstrated by in situ nick translation. These results indicated that the specific chromatin conformation that renders potentially active g...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90504-x
更新日期:1984-09-01 00:00:00
abstract::We have identified a novel octamer binding factor (Oct-3) in P19 embryonal carcinoma cells. Oct-3, which recognizes the typical octamer motif (ATTTGCAT) as well as the AT-rich sequence TTAAAATTCA, is present in P19 stem cells but disappears when the cells are induced to differentiate by retinoic acid (RA). Cloned cDNA...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90597-8
更新日期:1990-02-09 00:00:00
abstract::Pulses of ecdysteroids direct Drosophila through its life cycle by activating stage- and tissue-specific genetic regulatory hierarchies. Here we show that an orphan nuclear receptor, DHR78, functions at the top of the ecdysteroid regulatory hierarchies. Null mutations in DHR78 lead to lethality during the third larval...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81184-8
更新日期:1998-05-15 00:00:00
abstract::Reversible S-palmitoylation of cysteine residues critically controls transient membrane tethering of peripheral membrane proteins. Little is known about how the palmitoylation machinery governs their defined localization and function. We monitored the spatially resolved reaction dynamics and substrate specificity of t...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2010.04.007
更新日期:2010-04-30 00:00:00
abstract::Vascular permeability is frequently associated with inflammation and is triggered by a cohort of secreted permeability factors such as vascular endothelial growth factor (VEGF). Here, we show that the physiological vascular permeability that precedes implantation is directly controlled by progesterone receptor (PR) an...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.12.025
更新日期:2014-01-30 00:00:00
abstract::Fertilized clam embryos synthesize several new cell-cycle-related proteins. The cloned cDNA and derived amino acid sequences of one of these, cyclin A, are presented here. Immunoblots with an anti-cyclin A antibody reveal that cyclin A is undetectable in oocytes, appears within 15 min of fertilization, and is destroye...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(86)90801-9
更新日期:1986-12-26 00:00:00
abstract::The mechanisms by which immune checkpoint blockade modulates tumor evolution during therapy are unclear. We assessed genomic changes in tumors from 68 patients with advanced melanoma, who progressed on ipilimumab or were ipilimumab-naive, before and after nivolumab initiation (CA209-038 study). Tumors were analyzed by...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.09.028
更新日期:2017-11-02 00:00:00
abstract::As these paired Commentaries discuss, neuroscientists and architects are just beginning to collaborate, each bringing what they know about their respective fields to the task of improving the environment of research buildings and laboratories. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.10.012
更新日期:2006-10-20 00:00:00
abstract::Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates such as those associated with RNA processing, but the rules that dictate their assembly, substructure, and coexistence with other liquid-like compartments remain elusive. Here, we address the biophysical mechanism of this multiphase o...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.03.050
更新日期:2020-04-16 00:00:00
abstract::The hemagglutinin of influenza virus is synthesized as a monomeric subunit that is cotranslationally translocated across the membrane of the rough endoplasmic reticulum. We show that folding and assembly of hemagglutinin monomers into trimeric structures takes approximately 7-10 min and is completed before the protein...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(86)90076-0
更新日期:1986-09-12 00:00:00
abstract::Most mutations in cancer genomes are thought to be acquired after the initiating event, which may cause genomic instability and drive clonal evolution. However, for acute myeloid leukemia (AML), normal karyotypes are common, and genomic instability is unusual. To better understand clonal evolution in AML, we sequenced...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.06.023
更新日期:2012-07-20 00:00:00
abstract::Erythropoietin (EPO) production in the kidney is regulated by the oxygen-sensing transcription factor HIF-1α, which is degraded under normoxic conditions by HIF-prolyl hydroxylase (HIF-PHD). Inhibition of HIF-PHD by roxadustat leads to increased EPO production, better iron absorption, and amelioration of anemia in chr...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.12.010
更新日期:2020-01-09 00:00:00
abstract::Portions of the nascent chain are exposed to the lumen, the cytosol, or neither at different stages during the cotranslational integration of a protein into the ER membrane, as shown by compartment-specific collisional quenching of fluorophores incorporated into the polypeptide. The opening or closing of each end of t...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80311-6
更新日期:1997-07-11 00:00:00
abstract::X inactivation results in inactivation of one X chromosome to compensate for gene dosage differences between mammalian females and males. It requires the X-inactivation center (Xic) and Xist in cis. We report that introducing 450 kb of murine Xic/Xist sequences onto autosomes activates female dosage compensation in ma...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80079-3
更新日期:1996-07-12 00:00:00
abstract::Peptide growth factors may play a role in patterning of the early embryo, particularly in the induction of mesoderm. We have explored the role of fibroblast growth factor (FGF) in early Xenopus development by expressing a dominant negative mutant form of the FGF receptor. Using a functional assay in frog oocytes, we f...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90616-7
更新日期:1991-07-26 00:00:00
abstract::p120-catenin regulates cell-cell adhesion by controlling cell surface retention of cadherin. In this issue, Ishiyama et al. (2010) present the first crystal structure of p120 in complex with cadherin, revealing molecular details of the functional interface and providing sophisticated new tools for dissecting p120's ro...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2010.03.022
更新日期:2010-04-02 00:00:00
abstract::Transposon mutagenesis and complementation analysis of the photosynthesis genes in Rhodopseudomonas capsulata is presented utilizing Tn5.7 mutagenized R-primes. The R-prime pRPS404 contains many of the genes necessary for the differentiation of the photosynthetic apparatus. Utilizing homologous recombination, 30 indep...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90428-8
更新日期:1984-07-01 00:00:00
abstract::Natural killer (NK) cells play a key role in innate immunity by detecting alterations in self and non-self ligands via paired NK cell receptors (NKRs). Despite identification of numerous NKR-ligand interactions, physiological ligands for the prototypical NK1.1 orphan receptor remain elusive. Here, we identify a viral ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.03.002
更新日期:2017-03-23 00:00:00
abstract::It remains largely unknown how large-scale tissue movements during development emerge from the interplay of different tensile forces associated with actomyosin networks. Solon et al. (2009) now report that a ratchet-like mechanism drives the movement of epithelial sheets during dorsal closure in embryos of the fruit f...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2009.06.009
更新日期:2009-06-26 00:00:00
abstract::Nuclear matrices from undifferentiated and differentiated Friend erythroleukemia cells have been obtained by a method which removes DNA in a physiological buffer. These matrices preserved the characteristic topographical distribution of condensed and diffuse "chromatin" regions, as do nuclei in situ or isolated nuclei...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(79)90221-6
更新日期:1979-12-01 00:00:00