Specific and saturable binding of pp60v-src to plasma membranes: evidence for a myristyl-src receptor.

abstract：:We here attempt to achieve an integrated understanding of the structure and dynamics of a number of higher-order assemblies, including amyloids, various kinds of signalosomes, and cellular granules. We propose that the synergy between folded domains, linear motifs, and intrinsically disordered regions regulates the fo...

journal_title：Cell

authors： Wu H,Fuxreiter M

更新日期：2016-05-19 00:00:00

abstract：:We have used liposomes to deliver DNAase I inside normal Syrian hamster embryo (SHE) cells. We showed the entrance of DNAase I inside the cell by dose-dependent cytotoxicity; and the entrance of DNAase I into the nucleus by the induction of chromosomal aberrations and somatic mutation at the HPRT locus (but not at the...

journal_title：Cell

authors： Zajac-Kaye M,Ts'o PO

更新日期：1984-12-01 00:00:00

abstract：:Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTE...

journal_title：Cell

authors： Ciriello G,Gatza ML,Beck AH,Wilkerson MD,Rhie SK,Pastore A,Zhang H,McLellan M,Yau C,Kandoth C,Bowlby R,Shen H,Hayat S,Fieldhouse R,Lester SC,Tse GM,Factor RE,Collins LC,Allison KH,Chen YY,Jensen K,Johnson NB,O

更新日期：2015-10-08 00:00:00

abstract：:M-MuLV-specific DNA probes were used to establish the state of integration and amplification of recombinant proviral sequences in Moloney virus-induced tumors of Balb/Mo, Balb/c and 129 mice. The somatically acquired viral sequences contain both authentic M-MuLV genomes and recombinants of M-MuLV with endogenous viral...

journal_title：Cell

authors： van der Putten H,Quint W,van Raaij J,Maandag ER,Verma IM,Berns A

更新日期：1981-06-01 00:00:00

abstract：:A novel trimolecular mechanism of microbial attachment to mammalian host cells was characterized for the obligate intracellular pathogen Chlamydia trachomatis. Using purified glycosaminoglycans (GAGs) and specific GAG lyases, we demonstrated that a heparan sulfate-like GAG present on the surface of chlamydia organisms...

journal_title：Cell

authors： Zhang JP,Stephens RS

更新日期：1992-05-29 00:00:00

abstract：:Ovule development in Arabidopsis involves the formation of three morphologically defined proximal-distal pattern elements. Integuments arise from the central pattern element. Analysis of Bell 1 (Bel 1) mutant ovules indicated that BEL1 was required for integument development. Cloning of the BEL1 locus reveals that it ...

journal_title：Cell

authors： Reiser L,Modrusan Z,Margossian L,Samach A,Ohad N,Haughn GW,Fischer RL

更新日期：1995-12-01 00:00:00

abstract：:Replicative intermediates of SV40 were isolated, digested with the restriction endonuclease Bgl I and examined by electron microscopy. Over 98% of the replicative intermediates isolated following infection with wild-type virions at 33 degrees, 37 degrees or 40 degrees C or with tsA209 at 33 degrees C had initiated rep...

journal_title：Cell

authors： Martin RG,Setlow VP

更新日期：1980-06-01 00:00:00

abstract：:Transcription hinders replication fork progression and stability. The ATR checkpoint and specialized DNA helicases assist DNA synthesis across transcription units to protect genome integrity. Combining genomic and genetic approaches together with the analysis of replication intermediates, we searched for factors coord...

journal_title：Cell

authors： Alzu A,Bermejo R,Begnis M,Lucca C,Piccini D,Carotenuto W,Saponaro M,Brambati A,Cocito A,Foiani M,Liberi G

更新日期：2012-11-09 00:00:00

abstract：:We have established the DNA sequence of nine yeast mutants that prevent the expression either of the split cytochrome b gene alone (five mutants) or of two split genes, the cytochrome b gene and the cytochrome oxidase subunit I gene (four mutants). All the mutations analyzed are localized in intron 14 of the cob-box g...

journal_title：Cell

authors： De La Salle H,Jacq C,Slonimski PP

更新日期：1982-04-01 00:00:00

abstract：:Protein tethers can bridge gaps between membranes. Ren et al. (2009) now provide evidence that the yeast Dsl1 complex tethers vesicles to the endoplasmic reticulum (ER) by binding ER SNARE proteins at its base and capturing vesicles using a loop region that extends 20 nm from the ER membrane. ...

journal_title：Cell

authors： Schmitt HD,Jahn R

更新日期：2009-12-11 00:00:00

abstract：:This year, the Albert Lasker Basic Medical Research Award will be shared by Michael Sheetz, James Spudich, and Ronald Vale for discoveries concerning the biophysical actions of cytoskeletal motor-protein machines that move cargo within cells, contract muscles, and enable cell motility. ...

journal_title：Cell

authors： Ringe D,Petsko GA

更新日期：2012-09-14 00:00:00

abstract：:Adenovirus E1B 19 kDa protein protects against cell death induced by viral infection and certain external stimuli. The Bcl-2 protein can functionally substitute for the E1B 19 kDa protein. To identify cellular targets for the 19 kDa protein, we used the two-hybrid screen in yeast. We have isolated cDNAs for three diff...

journal_title：Cell

authors： Boyd JM,Malstrom S,Subramanian T,Venkatesh LK,Schaeper U,Elangovan B,D'Sa-Eipper C,Chinnadurai G

更新日期：1994-10-21 00:00:00

abstract：:The location of cis-acting regulatory sequences within the long terminal repeat (LTR) of the human T cell lymphotropic virus type III (HTLV-III/LAV) was determined. An enhancer element capable of increasing the rate of transcription from a heterologous promoter, irrespective of distance and orientation, is located bet...

journal_title：Cell

authors： Rosen CA,Sodroski JG,Haseltine WA

更新日期：1985-07-01 00:00:00

abstract：:Centrosome duplication is a critical step in assembly of the bipolar mitotic spindle, but the molecular mechanisms regulating this process during the cell cycle and during animal development are poorly understood. Here, we report that the zyg-1 gene of Caenorhabditis elegans is an essential regulator of centrosome dup...

journal_title：Cell

authors： O'Connell KF,Caron C,Kopish KR,Hurd DD,Kemphues KJ,Li Y,White JG

更新日期：2001-05-18 00:00:00

abstract：:The microtubule-based metaphase spindle is subjected to forces that act in diverse orientations and over a wide range of timescales. Currently, we cannot explain how this dynamic structure generates and responds to forces while maintaining overall stability, as we have a poor understanding of its micromechanical prope...

journal_title：Cell

authors： Shimamoto Y,Maeda YT,Ishiwata S,Libchaber AJ,Kapoor TM

更新日期：2011-06-24 00:00:00

abstract：:We have examined the conformation of DNA cloned from the hypersensitive region 5' of the chicken adult beta-globin gene, in order to determine whether the unusual sensitivity to nucleases is related to altered secondary structure of the DNA. The region contains a large number of sites for methylation; we have studied ...

journal_title：Cell

authors： Nickol JM,Felsenfeld G

更新日期：1983-12-01 00:00:00

abstract：:We have isolated the Drosophila melanogaster homolog (Dint-1) of int-1, a conserved cellular oncogene implicated in viral mammary tumorigenesis in mice. The deduced Dint-1 protein sequence contains 468 amino acids and starts with a hydrophobic leader; it is 54% identical to the int-1 sequence, and all 23 cysteine resi...

journal_title：Cell

authors： Rijsewijk F,Schuermann M,Wagenaar E,Parren P,Weigel D,Nusse R

更新日期：1987-08-14 00:00:00

abstract：:Novel, approximately 90 bp intervening sequences (IVs) were discovered within the 23S rRNA genes of S. typhimurium and S. arizonae. These non-rRNA sequences are transcribed and then excised during rRNA maturation. The rRNA fragments that result from the excision of the extra sequences are not religated. This results i...

journal_title：Cell

authors： Burgin AB,Parodos K,Lane DJ,Pace NR

更新日期：1990-02-09 00:00:00

abstract：:The pathway of RNA polymerase entry at the lac promoter was studied by investigating the relationship between the promoter and a weak, overlapping polymerase interaction site (P2). If polymerase is made to enter the DNA by binding in vitro at this P2 site, cyclic AMP receptor protein (CRP) actively removes polymerase ...

journal_title：Cell

authors： Meiklejohn AL,Gralla JD

更新日期：1985-12-01 00:00:00

abstract：:The somatic 5S DNA from X. borealis (Xbs 5S DNA) and X. laevis (Xis 5S DNA) and a minor oocyte-specific 5S DNA from X. laevis (Xit 5S DNA) have been purified, and individual repeating units have been cloned and sequenced. The two somatic 5S DNAs differ from the major oocyte 5S DNAs in having GC-rich spacers, homogeneo...

journal_title：Cell

authors： Peterson RC,Doering JL,Brown DD

更新日期：1980-05-01 00:00:00

abstract：:We have compared the chromatin structure in the active and inactive states at loci encoding the major heat shock protein in Drosophila. DNAase I and micrococcal nuclease were used as probes of higher order organization and nucleosomal integrity. Such integrity is gauged here by the characteristic pattern of discrete D...

journal_title：Cell

authors： Wu C,Wong YC,Elgin SC

更新日期：1979-04-01 00:00:00

abstract：:Spindle assembly required during mitosis depends on microtubule polymerization. We demonstrate that the evolutionarily conserved low-complexity protein, BuGZ, undergoes phase transition or coacervation to promote assembly of both spindles and their associated components. BuGZ forms temperature-dependent liquid droplet...

journal_title：Cell

authors： Jiang H,Wang S,Huang Y,He X,Cui H,Zhu X,Zheng Y

更新日期：2015-09-24 00:00:00

abstract：:The susceptibility to repair of particular base mismatches by the hex system of Streptococcus pneumoniae was examined by comparison of the nucleotide sequence of the wild-type and eight mutant alleles of the malM gene. A detailed restriction map was constructed for pLS70, and the nucleotide sequence was determined for...

journal_title：Cell

authors： Lacks SA,Dunn JJ,Greenberg B

更新日期：1982-12-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is one of the most common causes of death worldwide. We report in an emphysema model of mice chronically exposed to tobacco smoke that pulmonary vascular dysfunction, vascular remodeling, and pulmonary hypertension (PH) precede development of alveolar destruction. We provid...

journal_title：Cell

authors： Seimetz M,Parajuli N,Pichl A,Veit F,Kwapiszewska G,Weisel FC,Milger K,Egemnazarov B,Turowska A,Fuchs B,Nikam S,Roth M,Sydykov A,Medebach T,Klepetko W,Jaksch P,Dumitrascu R,Garn H,Voswinckel R,Kostin S,Seeger W,S

更新日期：2011-10-14 00:00:00

abstract：:Metabolic activity is intimately linked to T cell fate and function. Using high-resolution mass spectrometry, we generated dynamic metabolome and proteome profiles of human primary naive T cells following activation. We discovered critical changes in the arginine metabolism that led to a drop in intracellular L-argini...

journal_title：Cell

authors： Geiger R,Rieckmann JC,Wolf T,Basso C,Feng Y,Fuhrer T,Kogadeeva M,Picotti P,Meissner F,Mann M,Zamboni N,Sallusto F,Lanzavecchia A

更新日期：2016-10-20 00:00:00

abstract：:Eukaryotic translation initiation requires coordinated assembly of a remarkable array of initiation factors onto the small ribosomal subunit to select an appropriate mRNA start codon. Studies from Erzberger et al. and Hussain et al. bring new insights into this mechanism by looking at early and late initiation interme...

journal_title：Cell

authors： Korostelev AA

更新日期：2014-10-23 00:00:00

abstract：:Dominantly inherited mutations in an endoplasmic reticulum protein called VAPB have been found in a subset of patients with a rare familial form of amyotrophic lateral sclerosis (ALS). In this issue, Tsuda et al. (2008) identify a secreted form of VAPB that binds directly to Eph receptors inducing their activation and...

journal_title：Cell

authors： Ackerman SL,Cox GA

更新日期：2008-06-13 00:00:00

abstract：:We studied H1 gene expression in hybrids of Xenopus laevis (female) x Xenopus borealis (male) and saw paternal H1 synthesis in mid-blastulae, which indicates that the H1 genes are active by this stage. The behavior of the maternal store of H1 histone mRNA was studied in androgenetic haploids. In which all stored mRNA ...

journal_title：Cell

authors： Woodland HR,Flynn JM,Wyllie AJ

更新日期：1979-09-01 00:00:00

abstract：:Some proteins are too big to fit into conventional COPII-coated vesicles, which raises the question of how large cargo, such as procollagen fibrils, are exported from the endoplasmic reticulum. Jin et al. (2012) in Nature now report that the creation of oversized vesicles is facilitated by the ubiquitination of the CO...

journal_title：Cell

authors： Malhotra V

更新日期：2012-03-30 00:00:00

abstract：:At the replication origin of ColE1 plasmid, a persistent hybrid is formed between the primer precursor (RNA II) and its template DNA. The wild-type sequence in the region 13 to 20 bp upstream (-20 region) of the origin is required to form this persistent hybrid. While the template strand for transcription of this regi...

journal_title：Cell

authors： Masukata H,Tomizawa J

更新日期：1990-07-27 00:00:00