Epigenetics of reprogramming to induced pluripotency.

Abstract:

:Reprogramming to induced pluripotent stem cells (iPSCs) proceeds in a stepwise manner with reprogramming factor binding, transcription, and chromatin states changing during transitions. Evidence is emerging that epigenetic priming events early in the process may be critical for pluripotency induction later. Chromatin and its regulators are important controllers of reprogramming, and reprogramming factor levels, stoichiometry, and extracellular conditions influence the outcome. The rapid progress in characterizing reprogramming is benefiting applications of iPSCs and is already enabling the rational design of novel reprogramming factor cocktails. However, recent studies have also uncovered an epigenetic instability of the X chromosome in human iPSCs that warrants careful consideration.

journal_name

Cell

journal_title

Cell

authors

Papp B,Plath K

doi

10.1016/j.cell.2013.02.043

subject

Has Abstract

pub_date

2013-03-14 00:00:00

pages

1324-43

issue

6

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(13)00277-8

journal_volume

152

pub_type

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