Abstract:
:Reprogramming to induced pluripotent stem cells (iPSCs) proceeds in a stepwise manner with reprogramming factor binding, transcription, and chromatin states changing during transitions. Evidence is emerging that epigenetic priming events early in the process may be critical for pluripotency induction later. Chromatin and its regulators are important controllers of reprogramming, and reprogramming factor levels, stoichiometry, and extracellular conditions influence the outcome. The rapid progress in characterizing reprogramming is benefiting applications of iPSCs and is already enabling the rational design of novel reprogramming factor cocktails. However, recent studies have also uncovered an epigenetic instability of the X chromosome in human iPSCs that warrants careful consideration.
journal_name
Celljournal_title
Cellauthors
Papp B,Plath Kdoi
10.1016/j.cell.2013.02.043subject
Has Abstractpub_date
2013-03-14 00:00:00pages
1324-43issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(13)00277-8journal_volume
152pub_type
杂志文章,评审相关文献
CELL文献大全abstract::Activation of the transcription factor NF-kappaB by tumor necrosis factor (TNF) and interleukin-1 (IL-1) requires the NF-kappaB-inducing kinase (NIK). In a yeast two-hybrid screen for NIK-interacting proteins, we have identified a protein kinase previously known as CHUK. Overexpression of CHUK activates a NF-kappaB-de...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80344-x
更新日期:1997-07-25 00:00:00
abstract::SecA, the peripheral subunit of E. coli preprotein translocase, alternates between a membrane inserted and a deinserted state as part of the catalytic cycle of preprotein translocation. When SecA is complexed with SecY/E and preprotein, ATP drives a profound conformational change, leading to membrane insertion of a 30...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(94)90582-7
更新日期:1994-09-09 00:00:00
abstract::A functional cDNA from Aspergillus nidulans encoding triosephosphate isomerase (TPI) was isolated by its ability to complement a tpi1 mutation in Saccharomyces cerevisiae. This cDNA was used to obtain the corresponding gene, tpiA. Alignment of the cDNA and genomic DNA nucleotide sequences indicated that tpiA contains ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(86)90868-8
更新日期:1986-07-04 00:00:00
abstract::The v-erbB gene of avian erythroblastosis virus (AEV) codes for an integral plasma membrane glycoprotein, gp74erbB. Expression of gp74erbB and its intracellular precursors, gp66erbB and gp68erbB, has been studied in cells transformed by two temperature-sensitive mutants of AEV. After shift to 42 degrees C, the process...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90046-1
更新日期:1984-04-01 00:00:00
abstract::During fruiting body development, the product of the csgA gene is necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hr of starvation. From nascent wild-type fruiting bodies we have purified a polypeptide of 17 kd called C-factor, which, at approximately 1 ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90211-v
更新日期:1990-04-06 00:00:00
abstract::SR proteins constitute a family of pre-mRNA splicing factors that play important roles in both constitutive and regulated splicing. Here, we describe one member of the family, which we call SRp38, with unexpected properties. Unlike other SR proteins, SRp38 cannot activate splicing and is essentially inactive in splici...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(02)01038-3
更新日期:2002-11-01 00:00:00
abstract::Proteotypes, like genotypes, have been found to vary between individuals in several studies, but consistent molecular functional traits across studies remain to be quantified. In a meta-analysis of 11 proteomics datasets from humans and mice, we use co-variation of proteins in known functional modules across datasets ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.03.015
更新日期:2019-05-16 00:00:00
abstract::NF-kappa B is a nuclear protein, found only in cells that transcribe immunoglobulin light chain genes, that interacts with a defined site in the kappa immunoglobulin enhancer. This protein can be induced in pre-B cells by stimulation with bacterial lipopolysaccharide (LPS). The induction involves a posttranslational a...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(86)90807-x
更新日期:1986-12-26 00:00:00
abstract::Understanding molecular mechanisms that dictate B cell diversity is important for targeting B cells as anti-cancer treatment. Through the single-cell dissection of B cell heterogeneity in longitudinal samples of patients with breast cancer before and after neoadjuvant chemotherapy, we revealed that an ICOSL+ B cell su...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.02.015
更新日期:2020-03-19 00:00:00
abstract::The Hippo-signaling pathway is an important regulator of cellular proliferation and organ size. However, little is known about the role of this cascade in the control of cell fate. Employing a combination of lineage tracing, clonal analysis, and organoid culture approaches, we demonstrate that Hippo pathway activity i...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.03.060
更新日期:2014-06-05 00:00:00
abstract::Many naturalistic behaviors are built from modular components that are expressed sequentially. Although striatal circuits have been implicated in action selection and implementation, the neural mechanisms that compose behavior in unrestrained animals are not well understood. Here, we record bulk and cellular neural ac...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.04.019
更新日期:2018-06-28 00:00:00
abstract::Lymphocyte migration is essential for adaptive immune surveillance. However, our current understanding of this process is rudimentary, because most human studies have been restricted to immunological analyses of blood and various tissues. To address this knowledge gap, we used an integrated approach to characterize ti...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.11.019
更新日期:2020-12-23 00:00:00
abstract::Cytokine-activated receptors initiate intracellular signaling by recruiting protein kinases that phosphorylate the receptors on tyrosine residues, thus enabling docking of SH2 domain-bearing activating factors. Here we report that in response to type 1 interferon (IFNalpha), IFNalpha receptors recruit cytoplasmic CREB...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.07.034
更新日期:2007-10-05 00:00:00
abstract::beta-glucocerebrosidase, the enzyme defective in Gaucher disease, is targeted to the lysosome independently of the mannose-6-phosphate receptor. Affinity-chromatography experiments revealed that the lysosomal integral membrane protein LIMP-2 is a specific binding partner of beta-glucocerebrosidase. This interaction in...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.10.018
更新日期:2007-11-16 00:00:00
abstract::ROR-γt+ regulatory T cells (Tregs) of the colon can prevent excessive inflammation but also delay pathogen clearance. How these cells are regulated has remained elusive. In this issue of Cell, Ramanan et al. find that the set-point for ROR-γt+ Tregs is non-genetically maternally inherited during a critical time window...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2020.05.030
更新日期:2020-06-11 00:00:00
abstract::Inositol phosphates are well-known signaling molecules, whereas the inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (InsP7/IP7) and bis-diphosphoinositol tetrakisphosphate (InsP8/IP8), are less well characterized. We demonstrate physiologic regulation of Dictyostelium chemotaxis by InsP7 mediated ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(03)00640-8
更新日期:2003-09-05 00:00:00
abstract::Immune responses in diverse tissue sites are critical for protective immunity and homeostasis. Here, we investigate how tissue localization regulates the development and function of human natural killer (NK) cells, innate lymphocytes important for anti-viral and tumor immunity. Integrating high-dimensional analysis of...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.01.022
更新日期:2020-02-20 00:00:00
abstract::What happens to organelles during mitosis, and how they are apportioned to each of the daughter cells, is not completely clear. We have devised a procedure to address whether Golgi membranes fuse with the Endoplasmic Reticulum (ER) during mitosis via the detection of interactions between ER and Golgi proteins. This pr...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(03)01068-7
更新日期:2004-01-09 00:00:00
abstract::Clinical trials are key to translating scientific advances into progress in cancer research and care. Confronted by developments in basic science, the landscape of clinical cancer research is rapidly evolving. Here, we review recent changes in clinical trials' design and conduct, and we forecast future directions towa...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.01.027
更新日期:2017-02-09 00:00:00
abstract::Zika virus (ZIKV) is associated with severe neuropathology in neonates as well as Guillain-Barré syndrome and other neurologic disorders in adults. Prolonged viral shedding has been reported in semen, suggesting the presence of anatomic viral reservoirs. Here we show that ZIKV can persist in cerebrospinal fluid (CSF) ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.04.008
更新日期:2017-05-04 00:00:00
abstract::A Drosophila gene with similarity to the mammalian Ras GTPase activating protein has been isolated in screens for mutations that affect eye development. Inactivation of the locus, Gap1, mimics constitutive activation of the Sevenless receptor tyrosine kinase and eliminates the need for a functional Sevenless protein i...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90073-l
更新日期:1992-03-20 00:00:00
abstract::Dynamic changes in histone and transcription factor acetylation modulate gene expression. A study in Science (Wellen et al., 2009) reports that changes in glucose metabolism alter the availability of acetyl-CoA, the essential cofactor for protein acetylation. These findings reveal a direct connection between central m...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.06.025
更新日期:2009-07-10 00:00:00
abstract::Ubiquitin chains serve as a recognition motif for the proteasome, a multisubunit protease, which degrades its substrates into polypeptides while releasing ubiquitin for reuse. Yeast proteasomes contain two deubiquitinating enzymes, Ubp6 and Rpn11. Rpn11 promotes protein breakdown through its degradation-coupled activi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.07.038
更新日期:2006-10-06 00:00:00
abstract::The TDS4 gene of S. cerevisiae was isolated as an allele-specific high copy suppressor of mutations within the basic region of the TATA-binding protein (TBP). The gene is essential for viability and encodes a 596 aa protein. The first 300 aa of the TDS4 protein exhibit significant sequence similarity to the RNA polyme...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90351-c
更新日期:1992-10-16 00:00:00
abstract::Cell polarity is critical for T lymphocyte movement during their hunt for antigen-bearing cells and for infected target cells. In this issue of Cell, Yeh et al. (2008) now reveal a direct link between T cell polarity and the production of proinflammatory cytokines in mice lacking the class I MHC-restricted T cell-asso...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2008.02.016
更新日期:2008-03-07 00:00:00
abstract::Nucleosomes positioned over promoters are usually inhibitory to protein binding and activity. We analyzed at the nucleotide level of resolution the nucleosomal organization of a distal, liver-specific enhancer in various mouse tissues and found that the enhancer exists in an array of three precisely positioned nucleos...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(93)80079-t
更新日期:1993-10-22 00:00:00
abstract::Elucidating the global and local rules that govern genome-wide, hierarchical chromatin architecture remains a critical challenge. Current high-throughput chromosome conformation capture (Hi-C) technologies have identified large-scale chromatin structural motifs, such as topologically associating domains and looping. H...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.12.014
更新日期:2019-01-24 00:00:00
abstract::TOR complex 1 (TORC1) is a potent anabolic regulator of cellular growth and metabolism. When cells have sufficient amino acids, TORC1 is active due to its lysosomal localization mediated via the Rag GTPases. Upon amino acid removal, the Rag GTPases release TORC1, causing it to become cytoplasmic and inactive. We show ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.01.024
更新日期:2014-02-13 00:00:00
abstract::The axonal shafts of neurons contain bundled microtubules, whereas extending growth cones contain unbundled microtubule filaments, suggesting that localized activation of microtubule-associated proteins (MAP) at the transition zone may bundle these filaments during axonal growth. Dephosphorylation is thought to lead t...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.03.023
更新日期:2007-05-04 00:00:00
abstract::The yeast [PSI+] factor is inherited by a prion mechanism involving self-propagating Sup35p aggregates. We find that Sup35p prion function is conserved among distantly related yeasts. As with mammalian prions, a species barrier inhibits prion induction between Sup35p from different yeast species. This barrier is faith...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81565-2
更新日期:2000-01-21 00:00:00