Abstract：
:In atherosclerosis, the accumulation of apolipoprotein B-lipoproteins in the matrix beneath the endothelial cell layer of blood vessels leads to the recruitment of monocytes, the cells of the immune system that give rise to macrophages and dendritic cells. Macrophages derived from these recruited monocytes participate in a maladaptive, nonresolving inflammatory response that expands the subendothelial layer due to the accumulation of cells, lipid, and matrix. Some lesions subsequently form a necrotic core, triggering acute thrombotic vascular disease, including myocardial infarction, stroke, and sudden cardiac death. This Review discusses the central roles of macrophages in each of these stages of disease pathogenesis.
journal_name
Celljournal_title
Cellauthors
Moore KJ,Tabas Idoi
10.1016/j.cell.2011.04.005subject
Has Abstractpub_date
2011-04-29 00:00:00pages
341-55issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(11)00422-3journal_volume
145pub_type
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